Evidence map›Paper›PMID 35996497›Full record

ReviewBritish journal of biomedical science2022

Comparison Between Dichloroacetate and Phenylbutyrate Treatment for Pyruvate Dehydrogenase Deficiency.

Patricia Karissa, Timothy Simpson, Simon P Dawson, Teck Yew Low, Sook Hui Tay, Fatimah Diana Amin Nordin, Shamsul Mohd Zain, Pey Yee Lee, Yuh-Fen Pung

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in British journal of biomedical science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Mitochondrial Transplantation as a Therapeutic Strategy for Inherited Mitochondrial Diseases.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Patricia KarissaDivision of Biomedical Science, Faculty of Science and Engineering, University of Nottingham Malaysia, Semenyih, Malaysia.
Timothy SimpsonFaculty of Medicine and Health Sciences, University of Nottingham, Nottingham, United Kingdom.
Simon P DawsonFaculty of Medicine and Health Sciences, University of Nottingham, Nottingham, United Kingdom.
Teck Yew LowUKM Medical Molecular Biology Institute (UMBI), Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Sook Hui TayDivision of Biomedical Science, Faculty of Science and Engineering, University of Nottingham Malaysia, Semenyih, Malaysia.
Fatimah Diana Amin NordinInstitute for Medical Research (IMR), National Institutes of Health, Shah Alam, Malaysia.
Shamsul Mohd ZainDepartment of Pharmacology, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia.
Pey Yee LeeUKM Medical Molecular Biology Institute (UMBI), Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Yuh-Fen PungDivision of Biomedical Science, Faculty of Science and Engineering, University of Nottingham Malaysia, Semenyih, Malaysia.
University Kebangsaan Malaysia Medical Centre · MYUniversity of Nottingham · GBInstitute for Medical Research · MYUniversity of Malaya · MY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pyruvate dehydrogenase (PDH) deficiency is caused by a number of pathogenic variants and the most common are found in the

Indexed as

Pyruvate Dehydrogenase Complex Deficiency DiseaseHumansPhenylbutyratesPyruvate Dehydrogenase (Lipoamide)PhenylbutyratesPyruvate Dehydrogenase (Lipoamide)E1ainborn error of metabolismlactic acidosismitochondrial diseasePDHA1

Identifiers

PMID35996497
PMCPMC9302545
OpenAlexW4280626938

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.