Evidence map›Paper›PMID 35996192›Full record

ArticleRadiation oncology (London, England)2022

Clinical adoption patterns of 0.35 Tesla MR-guided radiation therapy in Europe and Asia.

Berend J Slotman, Mary Ann Clark, Enis Özyar, Myungsoo Kim, Jun Itami, Agnès Tallet, Jürgen Debus, Raphael Pfeffer, PierCarlo Gentile, Yukihiro Hama and 12 more

Open access · goldAbstract read
In one paragraph

Article in Radiation oncology (London, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 19 institutions in 12 countries.

Berend J SlotmanAmsterdamUMC, Loc VUMC, Amsterdam, The Netherlands.
Mary Ann ClarkViewRay, Inc., Suite 3000, 1099 18th Street, Denver, CO, 80202, USA. maclark@viewray.com.
Enis ÖzyarDepartment of Radiation Oncology, School of Medicine, Acibadem MAA University, Istanbul, Turkey.
Myungsoo KimDepartment of Radiation Oncology, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Jun ItamiRadiation Oncology, National Cancer Center Japan, Tokyo, Japan.
Agnès TalletRadiation Therapy Department, Institut Paoli-Calmettes, Marseille, France.
Jürgen DebusRadiation Oncology, Heidelberg University Hospital, Heidelberg, Germany.
Raphael PfefferRadiation Oncology, Assuta Medical Centers, Tel Aviv, Israel.
PierCarlo GentileRadiation Oncology, Ospedale San Pietro Fatebenefratelli di Roma, Rome, Italy.
Yukihiro HamaRadiation Oncology, Edogawa Hospital, Tokyo, Japan.
Nicolaus AndratschkeUniversitätsspital Zürich, University of Zurich, Zurich, Switzerland.
Olivier RiouMontpellier Cancer Institute (ICM), University Federation of Radiation Oncology of Mediterranean Occitanie, Montpellier University, INSERM U1194 IRCM, 34298, Montpellier, France.
Philip CamilleriRadiation Oncology, GenesisCare-Oxford, Oxford, UK.
Claus BelkaRadiation Oncology, Klinikum der Universität München, Munich, Germany.
Magali QuivrinRadiation Oncology, Centre Georges-Francois Leclerc, Dijon, France.
BoKyong KimDepartment of Radiation Oncology, Sheikh Khalifa Specialty Hospital, Ras Al Khaimah, United Arab Emirates.
Anders PedersenDepartment of Oncology, Rigshospitalet, Copenhagen, Denmark.
Mette van Overeem FelterAfdeling for Kræftbehandling, Herlev og Gentofte Hospital, Herlev, Denmark.
Young Il KimRadiation Oncology, Chungnam National University Sejong Hospital, Daejeon, Republic of Korea.
Jin Ho KimDepartment of Radiation Oncology, Seoul National University Hospital, Seoul, Republic of Korea.
Martin FussViewRay, Inc., Suite 3000, 1099 18th Street, Denver, CO, 80202, USA.
Vincenzo ValentiniRadiology, Radiation Oncology and Hematology Dept., Università Cattolica S.Cuore, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
ViewRay (United States) · USAcıbadem University · TRAgostino Gemelli University Polyclinic · ITAmsterdam University Medical Centers · NLAssuta Medical Center · ILCatholic University of Korea · KRCentre de Recherche en Cancérologie de Marseille · FRCentre Georges François Leclerc · FRChungnam National University Hospital · KREdogawa Hospital · JPGentofte Hospital · DKHeidelberg University · DELMU Klinikum · DEOspedale San Pietro Fatebenefratelli · ITRigshospitalet · DKSeoul National University Hospital · KRShaikh Khalifa Medical City · AEUniversité de Montpellier · FRUniversity Hospital of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMagnetic resonance-guided radiotherapy (MRgRT) utilization is rapidly expanding, driven by advanced capabilities including better soft tissue imaging, continuous intrafraction target visualization, automatic triggered beam delivery, and the availability of on-table adaptive replanning. Our objective was to describe patterns of 0.35 Tesla (T)-MRgRT utilization in Europe and Asia among early adopters of this novel technology.

methodsAnonymized administrative data from all 0.35T-MRgRT treatment systems in Europe and Asia were extracted for patients who completed treatment from 2015 to 2020. Detailed treatment information was analyzed for all MR-linear accelerators (linac) and -cobalt systems.

resultsFrom 2015 through the end of 2020, there were 5796 completed treatment courses delivered in 46,389 individual fractions. 23.5% of fractions were adapted. Ultra-hypofractionated (UHfx) dose schedules (1-5 fractions) were delivered for 63.5% of courses, with 57.8% of UHfx fractions adapted on-table. The most commonly treated tumor types were prostate (23.5%), liver (14.5%), lung (12.3%), pancreas (11.2%), and breast (8.0%), with increasing compound annual growth rates (CAGRs) in numbers of courses from 2015 through 2020 (pancreas: 157.1%; prostate: 120.9%; lung: 136.0%; liver: 134.2%).

conclusionsThis is the first comprehensive study reporting patterns of utilization among early adopters of a 0.35T-MRgRT system in Europe and Asia. Intrafraction MR image-guidance, advanced motion management, and increasing adoption of on-table adaptive RT have accelerated a transition to UHfx regimens. MRgRT has been predominantly used to treat tumors in the upper abdomen, pelvis and lungs, and increasingly with adaptive replanning, which is a radical departure from legacy radiotherapy practices.

Indexed as

RadiosurgeryRadiotherapy, Image-GuidedRadiotherapy, Intensity-ModulatedHumansMagnetic Resonance ImagingMaleParticle AcceleratorsRadiotherapy DosageRadiotherapy Planning, Computer-AssistedARTCare patternsMR-IGRTMRI-guided radiotherapyoARTOn-table adaptive radiation therapySABRSBRTStereotactic ablative radiation therapyStereotactic body radiotherapy

Identifiers

PMID35996192
PMCPMC9396857
OpenAlexW4292636027

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.