Evidence map›Paper›PMID 35995987›Full record

ArticleScientific reports2022

Field validation of deep learning based Point-of-Care device for early detection of oral malignant and potentially malignant disorders.

Praveen Birur N, Bofan Song, Sumsum P Sunny, Keerthi G, Pramila Mendonca, Nirza Mukhia, Shaobai Li, Sanjana Patrick, Shubha G, Subhashini A R and 17 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
6.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 9 institutions in 2 countries.

Praveen Birur N *Karnataka Lingayat Education Society's Institute of Dental Sciences, Bangalore, India.
Bofan Song *College of Optical Sciences, The University of Arizona, Tucson, AZ, USA.
Sumsum P Sunny *Integrated Head and Neck Oncology Program, Mazumdar Shaw Medical Foundation, Narayana Health City, Bommsandra Industrial Area, Bangalore, 99, India.
Keerthi GKarnataka Lingayat Education Society's Institute of Dental Sciences, Bangalore, India.
Pramila MendoncaDepartment of Head and Neck Surgical Oncology, Mazumdar Shaw Medical Center, Narayana Health City, Bangalore, India.
Nirza MukhiaKarnataka Lingayat Education Society's Institute of Dental Sciences, Bangalore, India.
Shaobai LiCollege of Optical Sciences, The University of Arizona, Tucson, AZ, USA.
Sanjana PatrickBiocon Foundation, Bangalore, India.
Shubha GKarnataka Lingayat Education Society's Institute of Dental Sciences, Bangalore, India.
Subhashini A RKarnataka Lingayat Education Society's Institute of Dental Sciences, Bangalore, India.
Tsusennaro ImchenChristian Institute of Health Sciences and Research, Dimapur, Nagaland, India.
Shirley T LeivonChristian Institute of Health Sciences and Research, Dimapur, Nagaland, India.
Trupti KolurDepartment of Head and Neck Surgical Oncology, Mazumdar Shaw Medical Center, Narayana Health City, Bangalore, India.
Vivek ShettyDepartment of Head and Neck Surgical Oncology, Mazumdar Shaw Medical Center, Narayana Health City, Bangalore, India.
Vidya Bhushan RDepartment of Head and Neck Surgical Oncology, Mazumdar Shaw Medical Center, Narayana Health City, Bangalore, India.
Daksha VaibhaviKarnataka Lingayat Education Society's Institute of Dental Sciences, Bangalore, India.
Surya RajeevKarnataka Lingayat Education Society's Institute of Dental Sciences, Bangalore, India.
Sneha PednekarKarnataka Lingayat Education Society's Institute of Dental Sciences, Bangalore, India.
Ankita Dutta BanikKarnataka Lingayat Education Society's Institute of Dental Sciences, Bangalore, India.
Rohan Michael RameshChristian Institute of Health Sciences and Research, Dimapur, Nagaland, India.
Vijay PillaiDepartment of Head and Neck Surgical Oncology, Mazumdar Shaw Medical Center, Narayana Health City, Bangalore, India.
Kathryn O SBeckman Laser Institute, University of California Irvine School of Medicine, Irvine, USA.
Petra Wilder SmithBeckman Laser Institute, University of California Irvine School of Medicine, Irvine, USA.
Alben SigamaniClinical Research, Mazumdar Shaw Medical Center, Bangalore, India.
Amritha SureshIntegrated Head and Neck Oncology Program, Mazumdar Shaw Medical Foundation, Narayana Health City, Bommsandra Industrial Area, Bangalore, 99, India. amritha.suresh@ms-mf.org.
Rongguang LiangCollege of Optical Sciences, The University of Arizona, Tucson, AZ, USA. rliang@optics.arizona.edu.
Moni A KuriakoseIntegrated Head and Neck Oncology Program, Mazumdar Shaw Medical Foundation, Narayana Health City, Bommsandra Industrial Area, Bangalore, 99, India. makuriakose@gmail.com.
Kamineni Institute of Dental Sciences · INNarayana Health · INChristian Institute of Health Sciences and Research Hospital · INUniversity of Arizona · USBeckman Laser Institute and Medical Clinic · USBiocon (India) · INMazumdar Shaw Medical Centre · INMazumdar Shaw Medical Foundation · INUniversity of California, Irvine · US

Funding

Multimodal Intraoral Imaging System for Oral Cancer Detection and Diagnosis in Low Resource SettingR01DE030682 · NIDCR · UNIVERSITY OF ARIZONA · PI LIANG, RONGGUANG · 2021 to 2025
$2.8M
Low-cost Mobile Oral Cancer Screening for Low Resource SettingUH3CA239682 · NCI · UNIVERSITY OF ARIZONA · PI LIANG, RONGGUANG · 2018 to 2020
$2.5M
Low-cost Mobile Oral Cancer Screening for Low Resource SettingUH2EB022623 · NIBIB · UNIVERSITY OF ARIZONA · PI LIANG, RONGGUANG · 2016 to 2017
$996k
NCI NIH HHS UH3 CA239682NIBIB NIH HHS UH2 EB022623NIDCR NIH HHS R01 DE030682NIH HHS UH2EB022623NIH HHS UH3CA239682
6 · The paper itself

Abstract

Early detection of oral cancer in low-resource settings necessitates a Point-of-Care screening tool that empowers Frontline-Health-Workers (FHW). This study was conducted to validate the accuracy of Convolutional-Neural-Network (CNN) enabled m(mobile)-Health device deployed with FHWs for delineation of suspicious oral lesions (malignant/potentially-malignant disorders). The effectiveness of the device was tested in tertiary-care hospitals and low-resource settings in India. The subjects were screened independently, either by FHWs alone or along with specialists. All the subjects were also remotely evaluated by oral cancer specialist/s. The program screened 5025 subjects (Images: 32,128) with 95% (n = 4728) having telediagnosis. Among the 16% (n = 752) assessed by onsite specialists, 20% (n = 102) underwent biopsy. Simple and complex CNN were integrated into the mobile phone and cloud respectively. The onsite specialist diagnosis showed a high sensitivity (94%), when compared to histology, while telediagnosis showed high accuracy in comparison with onsite specialists (sensitivity: 95%; specificity: 84%). FHWs, however, when compared with telediagnosis, identified suspicious lesions with less sensitivity (60%). Phone integrated, CNN (MobileNet) accurately delineated lesions (n = 1416; sensitivity: 82%) and Cloud-based CNN (VGG19) had higher accuracy (sensitivity: 87%) with tele-diagnosis as reference standard. The results of the study suggest that an automated mHealth-enabled, dual-image system is a useful triaging tool and empowers FHWs for oral cancer screening in low-resource settings.

Indexed as

Cell PhoneDeep LearningMouth NeoplasmsTelemedicineEarly Detection of CancerHumansPoint-of-Care Systems

Identifiers

PMID35995987
PMCPMC9395355
OpenAlexW4292608422

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.