ArticleScientific reports2022
Saliva microbiome, dietary, and genetic markers are associated with suicidal ideation in university students.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- The gut-brain axis and inflammatory mediators in suicide and mental disorders with high suicide rates: a review of current evidence.Dialogues in clinical neuroscience · 2026Review
- Association between oral microbiota and suicidal ideation among vocational high school students in China.BMC oral health · 2026Article
- Potential screening of oral squamous cell carcinoma using microRNA geno-assay by electrochemical sensing: a new platform in biosensor technology.RSC advances · 2026Article
- Novel insights into gut microbiota alterations in major depressive disorder with suicidal ideation: a metagenomic analysis.Frontiers in microbiology · 2026Article
- HLA Class II Alleles and Suicidal Behavior: Evidence from a Case-Control Study.International journal of molecular sciences · 2025Article
- Characterization of Gut Microbiome Composition in Depression and Completed Suicide.International journal of molecular sciences · 2025Article
- Characterization of the salivary microbiome in healthy individuals under fatigue status.Frontiers in cellular and infection microbiology · 2025Article
- Metagenomic analysis of salivary microbiota in patients with anorexia nervosa and association with functional digestive disorders (ORMICAN pilot study).BMJ nutrition, prevention & health · 2025Article
- Stress and mental health symptoms in early pregnancy are associated with the oral microbiome.BMJ mental health · 2024Article
- Is Late-Onset Suicidal Behavior a Distinct Subtype?The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2024Review
- A Holistic Approach for Ethics and Sustainability in the Food Chain: The Gateway to Oral and Systemic Health.Foods (Basel, Switzerland) · 2024Review
- Impact ofJournal of clinical medicine · 2024Review
- Article
- Inflammatory pathology in depression and suicide: a mechanistic distillation of clinical correlates.Frontiers in immunology · 2024Review
- Receptor-Independent Therapies for Forensic Detainees with Schizophrenia-Dementia Comorbidity.International journal of molecular sciences · 2023Article
- Translocation of Oral Microbiota into the Pancreatic Ductal Adenocarcinoma Tumor Microenvironment.Microorganisms · 2023Article
- Probing the Association between Cognition, Suicidal Behavior and Tryptophan Metabolism in a Sample of Individuals Living with Bipolar Disorder: A Secondary Analysis.Brain sciences · 2023Article
- RESCUE: a validated Nanopore pipeline to classify bacteria through long-read, 16S-ITS-23S rRNA sequencing.Frontiers in microbiology · 2023Article
- Neural bases of suicidal ideation and depression in young college students.Frontiers in psychology · 2023Article
- Beneficial modulation of human health in the oral cavity and beyond using bacteriocin-like inhibitory substance-producing streptococcal probiotics.Frontiers in microbiology · 2023Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Here, salivary microbiota and major histocompatibility complex (MHC) human leukocyte antigen (HLA) alleles were compared between 47 (12.6%) young adults with recent suicidal ideation (SI) and 325 (87.4%) controls without recent SI. Several bacterial taxa were correlated with SI after controlling for sleep issues, diet, and genetics. Four MHC class II alleles were protective for SI including DRB1*04, which was absent in every subject with SI while present in 21.7% of controls. Increased incidence of SI was observed with four other MHC class II alleles and two MHC class I alleles. Associations between these HLA alleles and salivary bacteria were also identified. Furthermore, rs10437629, previously associated with attempted suicide, was correlated here with SI and the absence of Alloprevotella rava, a producer of an organic acid known to promote brain energy homeostasis. Hence, microbial-genetic associations may be important players in the diathesis-stress model for suicidal behaviors.
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