Evidence map›Paper›PMID 35995882›Full record

ArticleDigestive diseases and sciences2023

Best Practices in Treatment of Laryngopharyngeal Reflux Disease: A Multidisciplinary Modified Delphi Study.

Afrin N Kamal, Shumon I Dhar, Jonathan M Bock, John O Clarke, Jerome R Lechien, Jacqueline Allen, Peter C Belafsky, Joel H Blumin, Walter W Chan, Ronnie Fass and 8 more

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Digestive diseases and sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Treatment for Laryngopharyngeal Reflux Disease: A Systematic Review of Controlled Studies.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
    Pooled it
  2. Article
  3. Efficacy of Psyllium Husk as an Adjunct to PPI in Treating Laryngopharyngeal Reflux: A Clinical Perspective.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2025
    Article
  4. Article
  5. [Content and development of pharyngology and laryngology].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2024
    Article
  6. Article
  7. ChatGPT-4 accuracy for patient education in laryngopharyngeal reflux.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024
    Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 14 institutions in 3 countries.

Afrin N Kamal *Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University, Redwood City, CA, USA. kamala@stanford.edu.ORCID http://orcid.org/0000-0001-8950-8916
Shumon I Dhar *Department of Otolaryngology, Head and Neck Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Jonathan M BockDepartment of Otolaryngology & Communication Sciences, Medical College of Wisconsin, Milwaukee, WI, USA.
John O ClarkeDivision of Gastroenterology and Hepatology, Department of Medicine, Stanford University, Redwood City, CA, USA.
Jerome R LechienDepartment of Otolaryngology Head Neck Surgery, Elsan Hospital, Paris, France.
Jacqueline AllenDepartment of Otolaryngology, Head and Neck Surgery, University of Auckland, Auckland, New Zealand.
Peter C BelafskyDepartment of Otolaryngology/Head and Neck Surgery, Davis School of Medicine, University of California, Sacramento, CA, USA.
Joel H BluminDepartment of Otolaryngology & Communication Sciences, Medical College of Wisconsin, Milwaukee, WI, USA.
Walter W ChanDivision of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Ronnie FassDivision of Gastroenterology, Department of Medicine, MetroHealth, Cleveland, OH, USA.
P Marco FisichellaAbbvie Inc., Chicago, IL, USA.
Michael MarohnDepartment of Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Ashli K O'RourkeDepartment of Otolaryngology, Head and Neck Surgery, Medical University of South Carolina, Charleston, SC, USA.
Gregory PostmaDepartment of Otolaryngology, Head and Neck Surgery, Augusta University, Augusta, GA, USA.
Edoardo V SavarinoDepartment of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy.
Michael F VaeziDivision of Gastroenterology, Department of Medicine, Vanderbilt University, Nashville, TN, USA.
Thomas L Carroll *Division of Otolaryngology and Harvard Medical School, Department of Otolaryngology-Head and Neck Surgery, Brigham and Women's Hospital, Boston, MA, USA.
Lee M Akst *Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Brigham and Women's Hospital · USJohns Hopkins University · USMedical College of Wisconsin · USAbbVie (United States) · USAugusta University · USMedical University of South Carolina · USMetroHealth · USStanford Medicine · USStanford University · USThe University of Texas Southwestern Medical Center · USUniversity of Auckland · NZUniversity of California, Davis · USUniversity of Padua · ITVanderbilt University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLaryngopharyngeal reflux (LPR) is a common otolaryngologic diagnosis. Treatment of presumed LPR remains challenging, and limited frameworks exist to guide treatment.

methodsUsing RAND/University of California, Los Angeles (UCLA) Appropriateness Methods, a modified Delphi approach identified consensus statements to guide LPR treatment. Experts independently and blindly scored proposed statements on importance, scientific acceptability, usability, and feasibility in a four-round iterative process. Accepted measures reached scores with ≥ 80% agreement in the 7-9 range (on a 9-point Likert scale) across all four categories.

resultsFifteen experts rated 36 proposed initial statements. In round one, 10 (27.8%) statements were rated as valid. In round two, 8 statements were modified based on panel suggestions, and experts subsequently rated 5 of these statements as valid. Round three's discussion refined statements not yet accepted, and in round four, additional voting identified 2 additional statements as valid. In total, 17 (47.2%) best practice statements reached consensus, touching on topics as varied as role of empiric treatment, medication use, lifestyle modifications, and indications for laryngoscopy.

conclusionUsing a well-tested methodology, best practice statements in the treatment of LPR were identified. The statements serve to guide physicians on LPR treatment considerations.

Indexed as

Laryngopharyngeal RefluxPhysiciansBehavior TherapyConsensusDelphi TechniqueHumansDelphiGastroesophageal refluxLaryngopharyngeal reflux

Identifiers

PMID35995882
OpenAlexW4292651849

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.