Evidence map›Paper›PMID 35995877›Full record

ArticleNature neuroscience2022

Long-lasting, dissociable improvements in working memory and long-term memory in older adults with repetitive neuromodulation.

Shrey Grover, Wen Wen, Vighnesh Viswanathan, Christopher T Gill, Robert M G Reinhart

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed, 7 pooled it
13.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

94 citing papers in PubMed, 7 syntheses or guidelines pooled it, 174 citations in OpenAlex.

  1. Efficacy and safety of tACS in older adults with cognitive impairment: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
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  2. Effects of transcranial alternating current stimulation on cognitive function in older adults: a systematic review and meta-analysis of randomized controlled trials.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
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34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Shrey GroverDepartment of Psychological and Brain Sciences, Boston University, Boston, MA, USA.ORCID http://orcid.org/0000-0003-3168-5543
Wen WenDepartment of Psychological and Brain Sciences, Boston University, Boston, MA, USA.
Vighnesh ViswanathanDepartment of Psychological and Brain Sciences, Boston University, Boston, MA, USA.
Christopher T GillDepartment of Psychological and Brain Sciences, Boston University, Boston, MA, USA.
Robert M G ReinhartDepartment of Psychological and Brain Sciences, Boston University, Boston, MA, USA. rmgr@bu.edu.ORCID http://orcid.org/0000-0003-2156-4633
Boston University · US

Funding

Improving Working Memory in Older Adults by Restoring Large-Scale Cortical InteractionsR01AG063775 · NIA · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI REINHART, ROBERT · 2019 to 2023
$2.1M
Causal Restructuring of Neural Rhythms Improves Adaptive BehaviorR01MH114877 · NIMH · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI REINHART, ROBERT · 2018 to 2022
$2.1M
NIA NIH HHS R01 AG063775NIMH NIH HHS R01 MH114877
6 · The paper itself

Abstract

The development of technologies to protect or enhance memory in older people is an enduring goal of translational medicine. Here we describe repetitive (4-day) transcranial alternating current stimulation (tACS) protocols for the selective, sustainable enhancement of auditory-verbal working memory and long-term memory in 65-88-year-old people. Modulation of synchronous low-frequency, but not high-frequency, activity in parietal cortex preferentially improved working memory on day 3 and day 4 and 1 month after intervention, whereas modulation of synchronous high-frequency, but not low-frequency, activity in prefrontal cortex preferentially improved long-term memory on days 2-4 and 1 month after intervention. The rate of memory improvements over 4 days predicted the size of memory benefits 1 month later. Individuals with lower baseline cognitive function experienced larger, more enduring memory improvements. Our findings demonstrate that the plasticity of the aging brain can be selectively and sustainably exploited using repetitive and highly focalized neuromodulation grounded in spatiospectral parameters of memory-specific cortical circuitry.

Indexed as

Memory, Short-TermTranscranial Direct Current StimulationAgedAged, 80 and overCognitionHumansMemory, Long-TermPrefrontal Cortex

Identifiers

PMID35995877
PMCPMC10068908
OpenAlexW4292641167

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.