ArticleNature communications2022
Human acute inflammatory recovery is defined by co-regulatory dynamics of white blood cell and platelet populations.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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48 citing papers in PubMed, 68 citations in OpenAlex.
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- Clinical outcomes and prognostic factors of open-window thoracostomy for empyema: a retrospective review of 40 patients.Surgery today · 2026Article
- Changes in leukocytes and CRP in different treatments of major depression.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Inflammatory Stewardship-A Perspective for Active Management of Acute Inflammation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Melanin nanoparticles-loaded lactobacillus fermentum exosomes for targeted and visualized treatment of ulcerative colitis.Journal of advanced research · 2026Article
- Ethyl p-methoxycinnamate Exhibits Superior Multi-Modal Anti-Inflammatory Activity Compared to Structurally Related Cinnamic Acid Derivatives.Journal of pharmacopuncture · 2026Article
- Association between platelet-white cell ratio and all-cause mortality in critically ill patients with atrial fibrillation: a retrospective cohort study.BMC cardiovascular disorders · 2026Article
- Complete blood count-based inflammation indexes and symptom severity in people with bipolar disorder: an analysis based on structural equation modelling.European archives of psychiatry and clinical neuroscience · 2026Article
- A minimal mathematical model of red blood cell homeostasis in anemia.PLoS computational biology · 2026Article
- C-Phycocyanin ameliorates ovarian hyperstimulation syndrome by mitigating inflammation and enhances fertility in an OHSS mouse model.Journal of ovarian research · 2026Article
- Toxicological Profile of aJournal of toxicology · 2026Article
- Long-term anakinra therapy in Schnitzler syndrome: real-world evidence on remission of neutrophilic dermatitis and systemic inflammation, safety, biomarker insights and dose optimization.Frontiers in immunology · 2026Observational
- Changes in equine complete blood count parameters and inflammatory indices with inflammation.Journal of equine veterinary science · 2025Article
- Triglyceride glucose related indices predict incident breast cancer risk in a population based cohort study.Discover oncology · 2025Article
- Fermented pickles improve gut microbiota and immune profile in women in a community trial in rural Pakistan.Scientific reports · 2025Article
- Whole blood count data and hematological parameters in US vegetarians: a cross-sectional study.European journal of nutrition · 2025Article
- Salivary Fistula as a Complication After the ORIF of a Mandibular Condylar Process Fracture: A Single-Centre Retrospective Study.Journal of functional biomaterials · 2025Article
- Exploring the impact of smoking on coronary heart disease risk in women: Insights from the NHANES database.Medicine · 2025Article
- Calprotectin as a Biomarker for Infectious Diseases: A Comparative Review with Conventional Inflammatory Markers.International journal of molecular sciences · 2025Review
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5 authors at 2 institutions in 1 country.
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Abstract
Inflammation is the physiologic reaction to cellular and tissue damage caused by trauma, ischemia, infection, and other pathologic conditions. Elevation of white blood cell count (WBC) and altered levels of other acute phase reactants are cardinal signs of inflammation, but the dynamics of these changes and their resolution are not well established. Here we studied inflammatory recovery from trauma, ischemia, and infection by tracking longitudinal dynamics of clinical laboratory measurements in hospitalized patients. We identified a universal recovery trajectory defined by exponential WBC decay and delayed linear growth of platelet count (PLT). Co-regulation of WBC-PLT dynamics is a fundamental mechanism of acute inflammatory recovery and provides a generic approach for identifying high-risk patients: 32x relative risk (RR) of adverse outcomes for cardiac surgery, 9x RR of death from COVID-19, 9x RR of death from sepsis, and 5x RR of death from myocardial infarction.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.