Evidence map›Paper›PMID 35995787›Full record

ArticleNature communications2022

Single cell transcriptomic analysis of the immune cell compartment in the human small intestine and in Celiac disease.

Nader Atlasy, Anna Bujko, Espen S Bækkevold, Peter Brazda, Eva Janssen-Megens, Knut E A Lundin, Jørgen Jahnsen, Frode L Jahnsen, Hendrik G Stunnenberg

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 48 citations in OpenAlex.

  1. Trial
  2. Gliadin-specific CD4Science advances · 2026
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  4. Review
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  6. Article
  7. T cell receptors for antigen on intraepithelial cytolytic T lymphocytes in celiac disease engage enterocyte HLA-E and HLA-B.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Cellular and molecular basis of proximal small intestine disorders.Nature reviews. Gastroenterology & hepatology · 2024
    Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Nader Atlasy *Department of Molecular Biology, Faculty of Science, Radboud University, Nijmegen, The Netherlands.ORCID 0000-0002-7841-6378
Anna Bujko *Department of Pathology, University of Oslo and Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Espen S BækkevoldDepartment of Pathology, University of Oslo and Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Peter BrazdaDepartment of Molecular Biology, Faculty of Science, Radboud University, Nijmegen, The Netherlands.ORCID 0000-0002-0215-1692
Eva Janssen-MegensDepartment of Molecular Biology, Faculty of Science, Radboud University, Nijmegen, The Netherlands.
Knut E A LundinKG Jebsen Coeliac Disease Research Centre, University of Oslo, Oslo, 0372, Norway.ORCID 0000-0003-1713-5545
Jørgen JahnsenDepartment of Gastroenterology, Akershus University Hospital and University of Oslo, Oslo, Norway.
Frode L JahnsenDepartment of Pathology, University of Oslo and Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Hendrik G StunnenbergDepartment of Molecular Biology, Faculty of Science, Radboud University, Nijmegen, The Netherlands. H.G.Stunnenberg@prinsesmaximacentrum.nl.ORCID 0000-0002-0066-1576
Oslo University Hospital · NORadboud University Nijmegen · NLUniversity of Oslo · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Celiac disease is an autoimmune disorder in which ingestion of dietary gluten triggers an immune reaction in the small intestine leading to destruction of the lining epithelium. Current treatment focusses on lifelong adherence to a gluten-free diet. Gluten-specific CD4

Indexed as

Celiac DiseaseCD8-Positive T-LymphocytesGlutensHumansIntestine, SmallTranscriptomeGlutens

Identifiers

PMID35995787
PMCPMC9395525
OpenAlexW4292608267

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.