ArticleNature communications2022
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force.
Open access · goldAbstract read
In one paragraph
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
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- Network-constrained Random Lasso for biologically interpretable gene network inference across unequal sample sizes.PloS one · 2026Article
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- Powerful gene network enrichment analysis and its application to severe COVID-19 gene network.Briefings in bioinformatics · 2025Article
- DD-CC-II: Data Driven Cell-Cell Interaction Inference and Its Application to COVID-19.International journal of molecular sciences · 2025Article
- Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution.Nature genetics · 2025Article
- Gene behaviors-based network enrichment analysis and its application to reveal immune disease pathways enriched with COVID-19 severity-specific gene networks.Bioinformatics (Oxford, England) · 2025Article
- Integrated analysis of COVID-19 multi-omics data for eQTLs reveals genetic mechanisms underlying disease severity.bioRxiv : the preprint server for biology · 2025Article
- Inflammatory metabolite 7α,25-OHC promotes TIMP1 expression in COVID-19 monocytes through synergy effect of SMARCC1/JUND/H3K27ac.Cellular and molecular life sciences : CMLS · 2025Article
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- Unraveling the COVID-19 Severity Hubs and Interplays in Inflammatory-Related RNA-Protein Networks.International journal of molecular sciences · 2025Article
- Germline variants and mosaic chromosomal alterations affect COVID-19 vaccine immunogenicity.Cell genomics · 2025Article
- Leveraging genome-wide association studies to better understand the etiology of cancers.Cancer science · 2025Review
- Computational network biology analysis revealed COVID-19 severity markers: Molecular interplay between HLA-II with CIITA.PloS one · 2025Article
- An IGHG1 variant exhibits polarized prevalence and confers enhanced IgG1 antibody responses against life-threatening organisms.Nature immunology · 2024Article
- Statistically and functionally fine-mapped blood eQTLs and pQTLs from 1,405 humans reveal distinct regulation patterns and disease relevance.Nature genetics · 2024Article
- Whole blood transcriptome analysis for age- and gender-specific gene expression profiling in Japanese individuals.Journal of biochemistry · 2024Article
- 1-L Transcription of SARS-CoV-2 Spike Protein S1 Subunit.International journal of molecular sciences · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
443 authors at 20 institutions in 3 countries.
Qingbo S WangDepartment of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.
Ryuya EdahiroDepartment of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.
Ho NamkoongDepartment of Infectious Diseases, Keio University School of Medicine, Tokyo, Japan.
Takanori HasegawaM&D Data Science Center, Tokyo Medical and Dental University, Tokyo, Japan.
Yuya ShiraiDepartment of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.
Kyuto SoneharaDepartment of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.
Hiromu TanakaDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Ho LeeDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Ryunosuke SaikiDepartment of Pathology and Tumor Biology, Kyoto University, Kyoto, Japan.ORCID 0000-0001-6984-7187
Takayoshi HyugajiDivision of Health Medical Intelligence, Human Genome Center, the Institute of Medical Science, the University of Tokyo, Tokyo, Japan.
Eigo ShimizuDivision of Health Medical Intelligence, Human Genome Center, the Institute of Medical Science, the University of Tokyo, Tokyo, Japan.
Kotoe KatayamaDivision of Health Medical Intelligence, Human Genome Center, the Institute of Medical Science, the University of Tokyo, Tokyo, Japan.ORCID 0000-0002-3966-1231
Masahiro KanaiDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-5165-4408
Tatsuhiko NaitoDepartment of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.ORCID 0000-0002-2779-4600
Noah SasaDepartment of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.
Kenichi YamamotoDepartment of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.ORCID 0000-0001-9594-7050
Yasuhiro KatoDepartment of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Japan.
Takayoshi MoritaDepartment of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Japan.
Kazuhisa TakahashiDepartment of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, Tokyo, Japan.ORCID 0000-0001-5749-4118
Norihiro HaradaDepartment of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, Tokyo, Japan.
Toshio NaitoDepartment of General Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, Tokyo, Japan.
Makoto HikiDepartment of Emergency and Disaster Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, Tokyo, Japan.
Yasushi MatsushitaDepartment of Internal Medicine and Rheumatology, Juntendo University Faculty of Medicine and Graduate School of Medicine, Tokyo, Japan.
Haruhi TakagiDepartment of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, Tokyo, Japan.
Masako IchikawaDepartment of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, Tokyo, Japan.
Ai NakamuraDepartment of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, Tokyo, Japan.
Sonoko HaradaDepartment of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, Tokyo, Japan.
Yuuki SandhuDepartment of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, Tokyo, Japan.
Hiroki KabataDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Katsunori MasakiDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Hirofumi KamataDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Shinnosuke IkemuraDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Shotaro ChubachiDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Satoshi OkamoriDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Hideki TeraiDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.ORCID 0000-0002-1118-1930
Atsuho MoritaDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Takanori AsakuraDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.ORCID 0000-0003-3122-6937
Junichi SasakiDepartment of Emergency and Critical Care Medicine, Keio University School of Medicine, Tokyo, Japan.
Hiroshi MorisakiDepartment of Anesthesiology, Keio University School of Medicine, Tokyo, Japan.
Yoshifumi UwaminoDepartment of Laboratory Medicine, Keio University School of Medicine, Tokyo, Japan.
Kosaku NankiDivision of Gastroenterology and Hepatology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Sho UchidaDepartment of Infectious Diseases, Keio University School of Medicine, Tokyo, Japan.
Shunsuke UnoDepartment of Infectious Diseases, Keio University School of Medicine, Tokyo, Japan.
Tomoyasu NishimuraDepartment of Infectious Diseases, Keio University School of Medicine, Tokyo, Japan.
Takashri IshiguroDepartment of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Kumagaya, Japan.
Taisuke IsonoDepartment of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Kumagaya, Japan.
Shun ShibataDepartment of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Kumagaya, Japan.
Yuma MatsuiDepartment of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Kumagaya, Japan.
Chiaki HosodaDepartment of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Kumagaya, Japan.
Kenji TakanoDepartment of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Kumagaya, Japan.
Takashi NishidaDepartment of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Kumagaya, Japan.
Yoichi KobayashiDepartment of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Kumagaya, Japan.
Yotaro TakakuDepartment of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Kumagaya, Japan.
Noboru TakayanagiDepartment of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Kumagaya, Japan.
Soichiro UedaJCHO (Japan Community Health care Organization) Saitama Medical Center, Internal Medicine, Saitama, Japan.
Ai TadaJCHO (Japan Community Health care Organization) Saitama Medical Center, Internal Medicine, Saitama, Japan.
Masayoshi MiyawakiJCHO (Japan Community Health care Organization) Saitama Medical Center, Internal Medicine, Saitama, Japan.
Masaomi YamamotoJCHO (Japan Community Health care Organization) Saitama Medical Center, Internal Medicine, Saitama, Japan.
Eriko YoshidaJCHO (Japan Community Health care Organization) Saitama Medical Center, Internal Medicine, Saitama, Japan.
Reina HayashiJCHO (Japan Community Health care Organization) Saitama Medical Center, Internal Medicine, Saitama, Japan.
Tomoki NagasakaJCHO (Japan Community Health care Organization) Saitama Medical Center, Internal Medicine, Saitama, Japan.
Sawako AraiJCHO (Japan Community Health care Organization) Saitama Medical Center, Internal Medicine, Saitama, Japan.
Yutaro KanekoJCHO (Japan Community Health care Organization) Saitama Medical Center, Internal Medicine, Saitama, Japan.
Kana SasakiJCHO (Japan Community Health care Organization) Saitama Medical Center, Internal Medicine, Saitama, Japan.
Etsuko TagayaDepartment of Respiratory Medicine, Tokyo Women's Medical University, Tokyo, Japan.
Masatoshi KawanaDepartment of General Medicine, Tokyo Women's Medical University, Tokyo, Japan.
Ken ArimuraDepartment of Respiratory Medicine, Tokyo Women's Medical University, Tokyo, Japan.
Kunihiko TakahashiM&D Data Science Center, Tokyo Medical and Dental University, Tokyo, Japan.
Tatsuhiko AnzaiM&D Data Science Center, Tokyo Medical and Dental University, Tokyo, Japan.
Satoshi ItoM&D Data Science Center, Tokyo Medical and Dental University, Tokyo, Japan.
Akifumi EndoClinical Research Center, Tokyo Medical and Dental University Hospital of Medicine, Tokyo, Japan.
Yuji UchimuraDepartment of Medical Informatics, Tokyo Medical and Dental University Hospital of Medicine, Tokyo, Japan.
Yasunari MiyazakiRespiratory Medicine, Tokyo Medical and Dental University, Tokyo, Japan.ORCID 0000-0002-9073-9815
Takayuki HondaRespiratory Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
Tomoya TateishiRespiratory Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
Shuji TohdaClinical Laboratory, Tokyo Medical and Dental University Hospital of Medicine, Tokyo, Japan.
Naoya IchimuraClinical Laboratory, Tokyo Medical and Dental University Hospital of Medicine, Tokyo, Japan.
Kazunari SonobeClinical Laboratory, Tokyo Medical and Dental University Hospital of Medicine, Tokyo, Japan.
Chihiro Tani SassaClinical Laboratory, Tokyo Medical and Dental University Hospital of Medicine, Tokyo, Japan.
Jun NakajimaClinical Laboratory, Tokyo Medical and Dental University Hospital of Medicine, Tokyo, Japan.
Yasushi NakanoKawasaki Municipal Ida Hospital, Department of Internal Medicine, Kawasaki, Japan.
Yukiko NakajimaKawasaki Municipal Ida Hospital, Department of Internal Medicine, Kawasaki, Japan.
Ryusuke AnanKawasaki Municipal Ida Hospital, Department of Internal Medicine, Kawasaki, Japan.
Ryosuke AraiKawasaki Municipal Ida Hospital, Department of Internal Medicine, Kawasaki, Japan.
Yuko KuriharaKawasaki Municipal Ida Hospital, Department of Internal Medicine, Kawasaki, Japan.
Yuko HaradaKawasaki Municipal Ida Hospital, Department of Internal Medicine, Kawasaki, Japan.
Kazumi NishioKawasaki Municipal Ida Hospital, Department of Internal Medicine, Kawasaki, Japan.
Tetsuya UedaDepartment of Respiratory Medicine, Osaka Saiseikai Nakatsu Hospital, Osaka, Japan.
Masanori AzumaDepartment of Respiratory Medicine, Osaka Saiseikai Nakatsu Hospital, Osaka, Japan.
Ryuichi SaitoDepartment of Respiratory Medicine, Osaka Saiseikai Nakatsu Hospital, Osaka, Japan.
Toshikatsu SadoDepartment of Respiratory Medicine, Osaka Saiseikai Nakatsu Hospital, Osaka, Japan.
Yoshimune MiyazakiDepartment of Respiratory Medicine, Osaka Saiseikai Nakatsu Hospital, Osaka, Japan.
Ryuichi SatoDepartment of Respiratory Medicine, Osaka Saiseikai Nakatsu Hospital, Osaka, Japan.
Yuki HarutaDepartment of Respiratory Medicine, Osaka Saiseikai Nakatsu Hospital, Osaka, Japan.
Tadao NagasakiDepartment of Respiratory Medicine, Osaka Saiseikai Nakatsu Hospital, Osaka, Japan.
Yoshinori YasuiDepartment of Infection Control, Osaka Saiseikai Nakatsu Hospital, Osaka, Japan.
Yoshinori HasegawaDepartment of Respiratory Medicine, Osaka Saiseikai Nakatsu Hospital, Osaka, Japan.
Yoshikazu MutohDepartment of Infectious Diseases, Tosei General Hospital, Seto, Japan.
Tomoki KimuraDepartment of Respiratory, Allergic Diseases Internal Medicine, Tosei General Hospital, Seto, Japan.
Tomonori SatoDepartment of Respiratory, Allergic Diseases Internal Medicine, Tosei General Hospital, Seto, Japan.
Reoto TakeiDepartment of Respiratory, Allergic Diseases Internal Medicine, Tosei General Hospital, Seto, Japan.
Satoshi HagimotoDepartment of Respiratory, Allergic Diseases Internal Medicine, Tosei General Hospital, Seto, Japan.
Yoichiro NoguchiDepartment of Respiratory, Allergic Diseases Internal Medicine, Tosei General Hospital, Seto, Japan.
Yasuhiko YamanoDepartment of Respiratory, Allergic Diseases Internal Medicine, Tosei General Hospital, Seto, Japan.
Hajime SasanoDepartment of Respiratory, Allergic Diseases Internal Medicine, Tosei General Hospital, Seto, Japan.
Sho OtaDepartment of Respiratory, Allergic Diseases Internal Medicine, Tosei General Hospital, Seto, Japan.
Yasushi NakamoriDepartment of Emergency and Critical Care Medicine, Kansai Medical University General Medical Center, Moriguchi, Japan.
Kazuhisa YoshiyaDepartment of Emergency and Critical Care Medicine, Kansai Medical University General Medical Center, Moriguchi, Japan.
Fukuki SaitoDepartment of Emergency and Critical Care Medicine, Kansai Medical University General Medical Center, Moriguchi, Japan.
Tomoyuki YoshiharaDepartment of Emergency and Critical Care Medicine, Kansai Medical University General Medical Center, Moriguchi, Japan.
Daiki WadaDepartment of Emergency and Critical Care Medicine, Kansai Medical University General Medical Center, Moriguchi, Japan.
Hiromu IwamuraDepartment of Emergency and Critical Care Medicine, Kansai Medical University General Medical Center, Moriguchi, Japan.
Syuji KanayamaDepartment of Emergency and Critical Care Medicine, Kansai Medical University General Medical Center, Moriguchi, Japan.
Shuhei MaruyamaDepartment of Emergency and Critical Care Medicine, Kansai Medical University General Medical Center, Moriguchi, Japan.
Takashi YoshiyamaJapan Anti-Tuberculosis Association (JATA) Fukujuji Hospital, Kiyose, Japan.
Ken OhtaJapan Anti-Tuberculosis Association (JATA) Fukujuji Hospital, Kiyose, Japan.
Hiroyuki KokutoJapan Anti-Tuberculosis Association (JATA) Fukujuji Hospital, Kiyose, Japan.
Hideo OgataJapan Anti-Tuberculosis Association (JATA) Fukujuji Hospital, Kiyose, Japan.
Yoshiaki TanakaJapan Anti-Tuberculosis Association (JATA) Fukujuji Hospital, Kiyose, Japan.
Kenichi ArakawaJapan Anti-Tuberculosis Association (JATA) Fukujuji Hospital, Kiyose, Japan.
Masafumi ShimodaJapan Anti-Tuberculosis Association (JATA) Fukujuji Hospital, Kiyose, Japan.
Takeshi OsawaJapan Anti-Tuberculosis Association (JATA) Fukujuji Hospital, Kiyose, Japan.
Hiroki TatenoDepartment of Pulmonary Medicine, Saitama City Hospital, Saitama, Japan.
Isano HaseDepartment of Pulmonary Medicine, Saitama City Hospital, Saitama, Japan.
Shuichi YoshidaDepartment of Pulmonary Medicine, Saitama City Hospital, Saitama, Japan.
Shoji SuzukiDepartment of Pulmonary Medicine, Saitama City Hospital, Saitama, Japan.
Miki KawadaDepartment of Infectious Diseases, Saitama City Hospital, Saitama, Japan.
Hirohisa HorinouchiDepartment of General Thoracic Surgery, Saitama City Hospital, Saitama, Japan.
Fumitake SaitoDepartment of Pulmonary Medicine, Eiju General Hospital, Tokyo, Japan.
Keiko MitamuraDivision of Infection Control, Eiju General Hospital, Tokyo, Japan.
Masao HagiharaDepartment of Hematology, Eiju General Hospital, Tokyo, Japan.
Junichi OchiDepartment of Pulmonary Medicine, Eiju General Hospital, Tokyo, Japan.
Tomoyuki UchidaDepartment of Hematology, Eiju General Hospital, Tokyo, Japan.
Rie BabaSaiseikai Utsunomiya Hospital, Utsunomiya, Japan.
Daisuke AraiSaiseikai Utsunomiya Hospital, Utsunomiya, Japan.
Takayuki OguraSaiseikai Utsunomiya Hospital, Utsunomiya, Japan.
Hidenori TakahashiSaiseikai Utsunomiya Hospital, Utsunomiya, Japan.
Shigehiro HagiwaraSaiseikai Utsunomiya Hospital, Utsunomiya, Japan.
Genta NagaoSaiseikai Utsunomiya Hospital, Utsunomiya, Japan.
Shunichiro KonishiSaiseikai Utsunomiya Hospital, Utsunomiya, Japan.
Ichiro NakachiSaiseikai Utsunomiya Hospital, Utsunomiya, Japan.
Koji MurakamiDepartment of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
Mitsuhiro YamadaDepartment of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.ORCID 0000-0002-0832-1939
Hisatoshi SugiuraDepartment of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.ORCID 0000-0002-4335-7048
Hirohito SanoDepartment of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.ORCID 0000-0003-2285-7577
Shuichiro MatsumotoDepartment of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
Nozomu KimuraDepartment of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
Yoshinao OnoDepartment of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
Hiroaki BabaDepartment of Infectious Diseases, Tohoku University Graduate School of Medicine, Sendai, Japan.
Yusuke SuzukiDepartment of Respiratory Medicine, Kitasato University Kitasato Institute Hospital, Tokyo, Japan.ORCID 0000-0001-9357-4852
Sohei NakayamaDepartment of Respiratory Medicine, Kitasato University Kitasato Institute Hospital, Tokyo, Japan.
Keita MasuzawaDepartment of Respiratory Medicine, Kitasato University Kitasato Institute Hospital, Tokyo, Japan.
Shinichi NambaDepartment of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.ORCID 0000-0002-7486-3146
Takayuki ShiroyamaDepartment of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Japan.
Yoshimi NodaDepartment of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Japan.
Takayuki NiitsuDepartment of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Japan.
Yuichi AdachiDepartment of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Japan.
Takatoshi EnomotoDepartment of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Japan.
Saori AmiyaDepartment of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Japan.
Reina HaraDepartment of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Japan.
Yuta YamaguchiDepartment of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Japan.ORCID 0000-0002-8314-9294
Teruaki MurakamiDepartment of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Japan.
Tomoki KugeDepartment of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Japan.
Kinnosuke MatsumotoDepartment of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Japan.
Yuji YamamotoDepartment of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Japan.
Makoto YamamotoDepartment of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Japan.
Midori YonedaDepartment of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Japan.
Kazunori TomonoDivision of Infection Control and Prevention, Osaka University Hospital, Suita, Japan.ORCID 0000-0002-3424-472X
Kazuto KatoDepartment of Biomedical Ethics and Public Policy, Osaka University Graduate School of Medicine, Suita, Japan.
Haruhiko HirataDepartment of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Japan.
Yoshito TakedaDepartment of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Japan.
Hidefumi KohTachikawa Hospital, Tachikawa, Japan.
Tadashi ManabeTachikawa Hospital, Tachikawa, Japan.ORCID 0000-0001-9891-5222
Yohei FunatsuTachikawa Hospital, Tachikawa, Japan.
Fumimaro ItoTachikawa Hospital, Tachikawa, Japan.
Takahiro FukuiTachikawa Hospital, Tachikawa, Japan.
Keisuke ShinozukaTachikawa Hospital, Tachikawa, Japan.
Sumiko KohashiTachikawa Hospital, Tachikawa, Japan.
Masatoshi MiyazakiTachikawa Hospital, Tachikawa, Japan.
Tomohisa ShokoDepartment of Emergency and Critical Care Medicine, Tokyo Women's Medical University Medical Center East, Tokyo, Japan.
Mitsuaki KojimaDepartment of Emergency and Critical Care Medicine, Tokyo Women's Medical University Medical Center East, Tokyo, Japan.
Tomohiro AdachiDepartment of Emergency and Critical Care Medicine, Tokyo Women's Medical University Medical Center East, Tokyo, Japan.
Motonao IshikawaDepartment of Medicine, Tokyo Women's Medical University Medical Center East, Tokyo, Japan.
Kenichiro TakahashiDepartment of Pediatrics, Tokyo Women's Medical University Medical Center East, Tokyo, Japan.
Takashi InoueInternal Medicine, Sano Kosei General Hospital, Sano, Japan.
Toshiyuki HiranoInternal Medicine, Sano Kosei General Hospital, Sano, Japan.
Keigo KobayashiInternal Medicine, Sano Kosei General Hospital, Sano, Japan.
Hatsuyo TakaokaInternal Medicine, Sano Kosei General Hospital, Sano, Japan.
Kazuyoshi WatanabeJapan Community Health care Organization Kanazawa Hospital, Kanazawa, Japan.
Naoki MiyazawaDepartment of Respiratory Medicine, Saiseikai Yokohamashi Nanbu Hospital, Yokohama, Japan.
Yasuhiro KimuraDepartment of Respiratory Medicine, Saiseikai Yokohamashi Nanbu Hospital, Yokohama, Japan.
Reiko SadoDepartment of Respiratory Medicine, Saiseikai Yokohamashi Nanbu Hospital, Yokohama, Japan.
Hideyasu SugimotoDepartment of Respiratory Medicine, Saiseikai Yokohamashi Nanbu Hospital, Yokohama, Japan.
Akane KamiyaDepartment of Clinical Laboratory, Saiseikai Yokohamashi Nanbu Hospital, Yokohama, Japan.
Naota KuwaharaInternal Medicine, Internal Medicine Center, Showa University Koto Toyosu Hospital, Tokyo, Japan.
Akiko FujiwaraInternal Medicine, Internal Medicine Center, Showa University Koto Toyosu Hospital, Tokyo, Japan.
Tomohiro MatsunagaInternal Medicine, Internal Medicine Center, Showa University Koto Toyosu Hospital, Tokyo, Japan.
Yoko SatoInternal Medicine, Internal Medicine Center, Showa University Koto Toyosu Hospital, Tokyo, Japan.
Takenori OkadaInternal Medicine, Internal Medicine Center, Showa University Koto Toyosu Hospital, Tokyo, Japan.
Yoshihiro HiraiDepartment of Respiratory Medicine, Japan Organization of Occupational Health and Safety, Kanto Rosai Hospital, Kawasaki, Japan.
Hidetoshi KawashimaDepartment of Respiratory Medicine, Japan Organization of Occupational Health and Safety, Kanto Rosai Hospital, Kawasaki, Japan.
Atsuya NaritaDepartment of Respiratory Medicine, Japan Organization of Occupational Health and Safety, Kanto Rosai Hospital, Kawasaki, Japan.
Kazuki NiwaDepartment of General Internal Medicine, Japan Organization of Occupational Health and Safety, Kanto Rosai Hospital, Kawasaki, Japan.
Yoshiyuki SekikawaDepartment of General Internal Medicine, Japan Organization of Occupational Health and Safety, Kanto Rosai Hospital, Kawasaki, Japan.
Koichi NishiIshikawa Prefectural Central Hospital, Kanazawa, Japan.
Masaru NishitsujiIshikawa Prefectural Central Hospital, Kanazawa, Japan.
Mayuko TaniIshikawa Prefectural Central Hospital, Kanazawa, Japan.
Junya SuzukiIshikawa Prefectural Central Hospital, Kanazawa, Japan.
Hiroki NakatsumiIshikawa Prefectural Central Hospital, Kanazawa, Japan.
Takashi OguraKanagawa Cardiovascular and Respiratory Center, Yokohama, Japan.
Hideya KitamuraKanagawa Cardiovascular and Respiratory Center, Yokohama, Japan.
Eri HagiwaraKanagawa Cardiovascular and Respiratory Center, Yokohama, Japan.
Kota MurohashiKanagawa Cardiovascular and Respiratory Center, Yokohama, Japan.
Hiroko OkabayashiKanagawa Cardiovascular and Respiratory Center, Yokohama, Japan.
Takao MochimaruDepartment of Respiratory Medicine, National Hospital Organization Tokyo Medical Center, Tokyo, Japan.
Shigenari NukagaDepartment of Respiratory Medicine, National Hospital Organization Tokyo Medical Center, Tokyo, Japan.
Ryosuke SatomiDepartment of Respiratory Medicine, National Hospital Organization Tokyo Medical Center, Tokyo, Japan.
Yoshitaka OyamadaDepartment of Respiratory Medicine, National Hospital Organization Tokyo Medical Center, Tokyo, Japan.
Nobuaki MoriDepartment of General Internal Medicine and Infectious Diseases, National Hospital Organization Tokyo Medical Center, Tokyo, Japan.
Tomoya BabaDepartment of Respiratory Medicine, Toyohashi Municipal Hospital, Toyohashi, Japan.
Yasutaka FukuiDepartment of Respiratory Medicine, Toyohashi Municipal Hospital, Toyohashi, Japan.
Mitsuru OdateDepartment of Respiratory Medicine, Toyohashi Municipal Hospital, Toyohashi, Japan.
Shuko MashimoDepartment of Respiratory Medicine, Toyohashi Municipal Hospital, Toyohashi, Japan.
Yasushi MakinoDepartment of Respiratory Medicine, Toyohashi Municipal Hospital, Toyohashi, Japan.
Kazuma YagiKeiyu Hospital, Yokohama, Japan.ORCID 0000-0002-9752-9589
Mizuha HashiguchiKeiyu Hospital, Yokohama, Japan.
Junko KagyoKeiyu Hospital, Yokohama, Japan.
Tetsuya ShiomiKeiyu Hospital, Yokohama, Japan.
Satoshi FukeKKR Sapporo Medical Center, Department of respiratory medicine, Sapporo, Japan.
Hiroshi SaitoKKR Sapporo Medical Center, Department of respiratory medicine, Sapporo, Japan.
Tomoya TsuchidaDivision of General Internal Medicine, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan.
Shigeki FujitaniDepartment of Emergency and Critical Care Medicine, St.Marianna University School of Medicine, Kawasaki, Japan.
Mumon TakitaDepartment of Emergency and Critical Care Medicine, St.Marianna University School of Medicine, Kawasaki, Japan.
Daiki MorikawaDepartment of Emergency and Critical Care Medicine, St.Marianna University School of Medicine, Kawasaki, Japan.
Toru YoshidaDepartment of Emergency and Critical Care Medicine, St.Marianna University School of Medicine, Kawasaki, Japan.
Takehiro IzumoJapanese Red Cross Medical Center, Tokyo, Japan.
Minoru InomataJapanese Red Cross Medical Center, Tokyo, Japan.
Naoyuki KuseJapanese Red Cross Medical Center, Tokyo, Japan.
Nobuyasu AwanoJapanese Red Cross Medical Center, Tokyo, Japan.
Mari ToneJapanese Red Cross Medical Center, Tokyo, Japan.
Akihiro ItoMatsumoto City Hospital, Matsumoto, Japan.
Yoshihiko NakamuraDepartment of Emergency and Critical Care Medicine, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
Kota HoshinoDepartment of Emergency and Critical Care Medicine, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
Junichi MaruyamaDepartment of Emergency and Critical Care Medicine, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
Hiroyasu IshikuraDepartment of Emergency and Critical Care Medicine, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
Tohru TakataDepartment of Infection Control, Fukuoka University Hospital, Fukuoka, Japan.
Toshio OdaniDepartment of Rheumatology, National Hospital Organization Hokkaido Medical Center, Sapporo, Japan.
Masaru AmishimaDepartment of Respiratory Medicine, National Hospital Organization Hokkaido Medical Center, Sapporo, Japan.
Takeshi HattoriDepartment of Respiratory Medicine, National Hospital Organization Hokkaido Medical Center, Sapporo, Japan.
Yasuo ShichinoheDepartment of Emergency and Critical Care Medicine, National Hospital Organization Hokkaido Medical Center, Sapporo, Japan.
Takashi KagayaNational Hospital Organization Kanazawa Medical Center, Kanazawa, Japan.
Toshiyuki KitaNational Hospital Organization Kanazawa Medical Center, Kanazawa, Japan.
Kazuhide OhtaNational Hospital Organization Kanazawa Medical Center, Kanazawa, Japan.
Satoru SakagamiNational Hospital Organization Kanazawa Medical Center, Kanazawa, Japan.
Kiyoshi KoshidaNational Hospital Organization Kanazawa Medical Center, Kanazawa, Japan.
Kentaro HayashiNihon University School of Medicine, Department of Internal Medicine, Division of Respiratory Medicine, Tokyo, Japan.
Tetsuo ShimizuNihon University School of Medicine, Department of Internal Medicine, Division of Respiratory Medicine, Tokyo, Japan.
Yutaka KozuNihon University School of Medicine, Department of Internal Medicine, Division of Respiratory Medicine, Tokyo, Japan.
Hisato HiranumaNihon University School of Medicine, Department of Internal Medicine, Division of Respiratory Medicine, Tokyo, Japan.
Yasuhiro GonNihon University School of Medicine, Department of Internal Medicine, Division of Respiratory Medicine, Tokyo, Japan.
Namiki IzumiMusashino Red Cross Hospital, Musashino, Japan.
Kaoru NagataMusashino Red Cross Hospital, Musashino, Japan.
Ken UedaMusashino Red Cross Hospital, Musashino, Japan.
Reiko TakiMusashino Red Cross Hospital, Musashino, Japan.
Satoko HanadaMusashino Red Cross Hospital, Musashino, Japan.
Kodai KawamuraDivision of Respiratory Medicine, Social Welfare Organization Saiseikai Imperial Gift Foundation, Inc., Saiseikai Kumamoto Hospital, Kumamoto, Japan.
Kazuya IchikadoDivision of Respiratory Medicine, Social Welfare Organization Saiseikai Imperial Gift Foundation, Inc., Saiseikai Kumamoto Hospital, Kumamoto, Japan.
Kenta NishiyamaDivision of Respiratory Medicine, Social Welfare Organization Saiseikai Imperial Gift Foundation, Inc., Saiseikai Kumamoto Hospital, Kumamoto, Japan.
Hiroyuki MuranakaDivision of Respiratory Medicine, Social Welfare Organization Saiseikai Imperial Gift Foundation, Inc., Saiseikai Kumamoto Hospital, Kumamoto, Japan.
Kazunori NakamuraDivision of Respiratory Medicine, Social Welfare Organization Saiseikai Imperial Gift Foundation, Inc., Saiseikai Kumamoto Hospital, Kumamoto, Japan.
Naozumi HashimotoDepartment of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.ORCID 0000-0003-2337-629X
Keiko WakaharaDepartment of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Sakamoto KojiDepartment of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Norihito OmoteDepartment of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Akira AndoDepartment of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Nobuhiro KodamaFukuoka Tokushukai Hospital, Department of Internal Medicine, Kasuga, Japan.
Yasunari KaneyamaFukuoka Tokushukai Hospital, Department of Internal Medicine, Kasuga, Japan.
Shunsuke MaedaFukuoka Tokushukai Hospital, Department of Internal Medicine, Kasuga, Japan.
Takashige KurakiFukuoka Tokushukai Hospital, Respiratory Medicine, Kasuga, Japan.
Takemasa MatsumotoFukuoka Tokushukai Hospital, Respiratory Medicine, Kasuga, Japan.
Koutaro YokoteDepartment of Endocrinology, Hematology and Gerontology, Chiba University Graduate School of Medicine, Chiba, Japan.
Taka-Aki NakadaDepartment of Emergency and Critical Care Medicine, Chiba University Graduate School of Medicine, Chiba, Japan.
Ryuzo AbeDepartment of Emergency and Critical Care Medicine, Chiba University Graduate School of Medicine, Chiba, Japan.
Taku OshimaDepartment of Emergency and Critical Care Medicine, Chiba University Graduate School of Medicine, Chiba, Japan.
Tadanaga ShimadaDepartment of Emergency and Critical Care Medicine, Chiba University Graduate School of Medicine, Chiba, Japan.
Masahiro HaradaNational Hospital Organization Kumamoto Medical Center, Kumamoto, Japan.ORCID 0000-0002-0162-5390
Takeshi TakahashiNational Hospital Organization Kumamoto Medical Center, Kumamoto, Japan.
Hiroshi OnoNational Hospital Organization Kumamoto Medical Center, Kumamoto, Japan.
Toshihiro SakuraiNational Hospital Organization Kumamoto Medical Center, Kumamoto, Japan.
Takayuki ShibusawaNational Hospital Organization Kumamoto Medical Center, Kumamoto, Japan.
Yoshifumi KimizukaDivision of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine, National Defense Medical College, Tokorozawa, Japan.ORCID 0000-0002-4026-7506
Akihiko KawanaDivision of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine, National Defense Medical College, Tokorozawa, Japan.
Tomoya SanoDivision of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine, National Defense Medical College, Tokorozawa, Japan.
Chie WatanabeDivision of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine, National Defense Medical College, Tokorozawa, Japan.
Ryohei SuematsuDivision of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine, National Defense Medical College, Tokorozawa, Japan.
Hisako SageshimaSapporo City General Hospital, Sapporo, Japan.
Ayumi YoshifujiDepartment of Internal Medicine, Tokyo Saiseikai Central Hospital, Tokyo, Japan.
Kazuto ItoDepartment of Internal Medicine, Tokyo Saiseikai Central Hospital, Tokyo, Japan.
Saeko TakahashiDepartment of Pulmonary Medicine, Tokyo Saiseikai Central Hospital, Tokyo, Japan.
Kota IshiokaDepartment of Pulmonary Medicine, Tokyo Saiseikai Central Hospital, Tokyo, Japan.
Morio NakamuraDepartment of Pulmonary Medicine, Tokyo Saiseikai Central Hospital, Tokyo, Japan.
Makoto MasudaDepartment of Respiratory Medicine, Fujisawa City Hospital, Fujisawa, Japan.
Aya WakabayashiDepartment of Respiratory Medicine, Fujisawa City Hospital, Fujisawa, Japan.
Hiroki WatanabeDepartment of Respiratory Medicine, Fujisawa City Hospital, Fujisawa, Japan.
Suguru UedaDepartment of Respiratory Medicine, Fujisawa City Hospital, Fujisawa, Japan.
Masanori NishikawaDepartment of Respiratory Medicine, Fujisawa City Hospital, Fujisawa, Japan.
Yusuke ChiharaUji-Tokushukai Medical Center, Uji, Japan.
Mayumi TakeuchiUji-Tokushukai Medical Center, Uji, Japan.
Keisuke OnoiUji-Tokushukai Medical Center, Uji, Japan.
Jun ShinozukaUji-Tokushukai Medical Center, Uji, Japan.
Atsushi SueyoshiUji-Tokushukai Medical Center, Uji, Japan.
Yoji NagasakiDepartment of Infectious Disease and Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan.
Masaki OkamotoDepartment of Respirology, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan.
Sayoko IshiharaDepartment of Infectious Disease, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan.
Masatoshi ShimoDepartment of Infectious Disease, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan.
Yoshihisa TokunagaDepartment of Respirology, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan.
Yu KusakaOme Municipal General Hospital, Ome, Japan.
Takehiko OhbaOme Municipal General Hospital, Ome, Japan.
Susumu IsogaiOme Municipal General Hospital, Ome, Japan.
Aki OgawaOme Municipal General Hospital, Ome, Japan.
Takuya InoueOme Municipal General Hospital, Ome, Japan.
Satoru FukuyamaResearch Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Yoshihiro EriguchiDepartment of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Akiko YonekawaDepartment of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Keiko Kan-OResearch Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Koichiro MatsumotoResearch Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Kensuke KanaokaDaini Osaka Police Hospital, Osaka, Japan.
Shoichi IharaDaini Osaka Police Hospital, Osaka, Japan.
Kiyoshi KomutaDaini Osaka Police Hospital, Osaka, Japan.
Yoshiaki InoueDepartment of Emergency and Critical Care Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Shigeru ChibaDepartment of Hematology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Kunihiro YamagataDepartment of Nephrology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.ORCID 0000-0002-7407-0410
Yuji HiramatsuDepartment of Cardiovascular Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Hirayasu KaiDepartment of Nephrology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Koichiro AsanoDivision of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Isehara, Japan.
Tsuyoshi OgumaDivision of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Isehara, Japan.
Yoko ItoDivision of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Isehara, Japan.
Satoru HashimotoDepartment of Anesthesiology and Intensive Care Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Masaki YamasakiDepartment of Anesthesiology and Intensive Care Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Yu KasamatsuDepartment of Infection Control and Laboratory Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Yuko KomaseDepartment of Respiratory Internal Medicine, St Marianna University School of Medicine, Yokohama-City Seibu Hospital, Yokohama, Japan.
Naoya HidaDepartment of Respiratory Internal Medicine, St Marianna University School of Medicine, Yokohama-City Seibu Hospital, Yokohama, Japan.
Takahiro TsuburaiDepartment of Respiratory Internal Medicine, St Marianna University School of Medicine, Yokohama-City Seibu Hospital, Yokohama, Japan.
Baku OyamaDepartment of Respiratory Internal Medicine, St Marianna University School of Medicine, Yokohama-City Seibu Hospital, Yokohama, Japan.
Minoru TakadaKINSHUKAI Hanwa The Second Hospital, Osaka, Japan.
Hidenori KandaKINSHUKAI Hanwa The Second Hospital, Osaka, Japan.
Yuichiro KitagawaGifu University School of Medicine Graduate School of Medicine, Emergency and Disaster Medicine, Gifu, Japan.
Tetsuya FukutaGifu University School of Medicine Graduate School of Medicine, Emergency and Disaster Medicine, Gifu, Japan.
Takahito MiyakeGifu University School of Medicine Graduate School of Medicine, Emergency and Disaster Medicine, Gifu, Japan.
Shozo YoshidaGifu University School of Medicine Graduate School of Medicine, Emergency and Disaster Medicine, Gifu, Japan.
Shinji OguraGifu University School of Medicine Graduate School of Medicine, Emergency and Disaster Medicine, Gifu, Japan.
Shinji AbeDepartment of Respiratory Medicine, Tokyo Medical University Hospital, Tokyo, Japan.
Yuta KonoDepartment of Respiratory Medicine, Tokyo Medical University Hospital, Tokyo, Japan.
Yuki TogashiDepartment of Respiratory Medicine, Tokyo Medical University Hospital, Tokyo, Japan.
Hiroyuki TakoiDepartment of Respiratory Medicine, Tokyo Medical University Hospital, Tokyo, Japan.
Ryota KikuchiDepartment of Respiratory Medicine, Tokyo Medical University Hospital, Tokyo, Japan.
Shinichi OgawaJA Toride medical hospital, Toride, Japan.
Tomouki OgataJA Toride medical hospital, Toride, Japan.
Shoichiro IshiharaJA Toride medical hospital, Toride, Japan.
Arihiko KanehiroOkayama Rosai Hospital, Okayama, Japan.
Shinji OzakiOkayama Rosai Hospital, Okayama, Japan.
Yasuko FuchimotoOkayama Rosai Hospital, Okayama, Japan.
Sae WadaOkayama Rosai Hospital, Okayama, Japan.
Nobukazu FujimotoOkayama Rosai Hospital, Okayama, Japan.
Kei NishiyamaEmergency & Critical Care, Niigata University, Niigata, Japan.
Mariko TerashimaEmergency & Critical Care Center, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
Satoru BeppuEmergency & Critical Care Center, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
Kosuke YoshidaEmergency & Critical Care Center, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
Osamu NarumotoNational Hospital Organization Tokyo Hospital Hospital, Kiyose, Japan.
Hideaki NagaiNational Hospital Organization Tokyo Hospital Hospital, Kiyose, Japan.
Nobuharu OoshimaNational Hospital Organization Tokyo Hospital Hospital, Kiyose, Japan.
Mitsuru MotegiFujioka General Hospital, Fujioka, Japan.
Akira UmedaDepartment of General Medicine, School of Medicine, International University of Health and Welfare Shioya Hospital, Ohtawara, Japan.
Kazuya MiyagawaDepartment of Pharmacology, School of Pharmacy, International University of Health and Welfare Shioya Hospital, Ohtawara, Japan.
Hisato ShimadaDepartment of Respiratory Medicine, International University of Health and Welfare Shioya Hospital, Ohtawara, Japan.
Mayu EndoDepartment of Clinical Laboratory, International University of Health and Welfare Shioya Hospital, Ohtawara, Japan.
Yoshiyuki OhiraDepartment of General Medicine, School of Medicine, International University of Health and Welfare Shioya Hospital, Ohtawara, Japan.
Masafumi WatanabeDepartment of Cardiology, Pulmonology, and Nephrology, Yamagata University Faculty of Medicine, Yamagata, Japan.
Sumito InoueDepartment of Cardiology, Pulmonology, and Nephrology, Yamagata University Faculty of Medicine, Yamagata, Japan.
Akira IgarashiDepartment of Cardiology, Pulmonology, and Nephrology, Yamagata University Faculty of Medicine, Yamagata, Japan.
Masamichi SatoDepartment of Cardiology, Pulmonology, and Nephrology, Yamagata University Faculty of Medicine, Yamagata, Japan.
Hironori SagaraDivision of Respiratory Medicine and Allergology, Department of Medicine, School of Medicine, Showa University, Tokyo, Japan.
Akihiko TanakaDivision of Respiratory Medicine and Allergology, Department of Medicine, School of Medicine, Showa University, Tokyo, Japan.
Shin OhtaDivision of Respiratory Medicine and Allergology, Department of Medicine, School of Medicine, Showa University, Tokyo, Japan.ORCID 0000-0001-8744-6096
Tomoyuki KimuraDivision of Respiratory Medicine and Allergology, Department of Medicine, School of Medicine, Showa University, Tokyo, Japan.
Yoko ShibataDepartment of Pulmonary Medicine, Fukushima Medical University, Fukushima, Japan.
Yoshinori TaninoDepartment of Pulmonary Medicine, Fukushima Medical University, Fukushima, Japan.ORCID 0000-0003-2384-601X
Takefumi NikaidoDepartment of Pulmonary Medicine, Fukushima Medical University, Fukushima, Japan.
Hiroyuki MinemuraDepartment of Pulmonary Medicine, Fukushima Medical University, Fukushima, Japan.
Yuki SatoDepartment of Pulmonary Medicine, Fukushima Medical University, Fukushima, Japan.
Yuichiro YamadaKansai Electric Power Hospital, Osaka, Japan.
Takuya HashinoKansai Electric Power Hospital, Osaka, Japan.
Masato ShinokiKansai Electric Power Hospital, Osaka, Japan.
Hajime IwagoeDivision of Infectious Diseases, Kumamoto City Hospital, Kumamoto, Japan.
Hiroshi TakahashiDepartment of Respiratory Medicine, Kumamoto City Hospital, Kumamoto, Japan.
Kazuhiko FujiiDepartment of Respiratory Medicine, Kumamoto City Hospital, Kumamoto, Japan.
Hiroto KishiDepartment of Respiratory Medicine, Kumamoto City Hospital, Kumamoto, Japan.
Masayuki KanaiDepartment of Emergency and Critical Care Medicine, Tokyo Metropolitan Police Hospital, Tokyo, Japan.
Tomonori ImamuraDepartment of Emergency and Critical Care Medicine, Tokyo Metropolitan Police Hospital, Tokyo, Japan.
Tatsuya YamashitaDepartment of Emergency and Critical Care Medicine, Tokyo Metropolitan Police Hospital, Tokyo, Japan.
Masakiyo YatomiDepartment of Respiratory Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan.
Toshitaka MaenoDepartment of Respiratory Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan.
Shinichi HayashiNational hospital organization Saitama Hospital, Wako, Japan.
Mai TakahashiNational hospital organization Saitama Hospital, Wako, Japan.
Mizuki KuramochiNational hospital organization Saitama Hospital, Wako, Japan.
Isamu KamimakiNational hospital organization Saitama Hospital, Wako, Japan.
Yoshiteru TominagaNational hospital organization Saitama Hospital, Wako, Japan.
Tomoo IshiiTokyo Medical University Ibaraki Medical Center, Inashiki, Japan.
Mitsuyoshi UtsugiDepartment of Internal Medicine, Kiryu Kosei General Hospital, Kiryu, Japan.
Akihiro OnoDepartment of Internal Medicine, Kiryu Kosei General Hospital, Kiryu, Japan.
Toru TanakaDepartment of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
Takeru KashiwadaDepartment of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
Kazue FujitaDepartment of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
Yoshinobu SaitoDepartment of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
Masahiro SeikeDepartment of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
Hiroko WatanabeDivision of Respiratory Medicine, Tsukuba Kinen General Hospital, Tsukuba, Japan.
Hiroto MatsuseDivision of Respiratory Medicine, Department of Internal Medicine, Toho University Ohashi Medical Center, Tokyo, Japan.
Norio KodakaDivision of Respiratory Medicine, Department of Internal Medicine, Toho University Ohashi Medical Center, Tokyo, Japan.
Chihiro NakanoDivision of Respiratory Medicine, Department of Internal Medicine, Toho University Ohashi Medical Center, Tokyo, Japan.
Takeshi OshioDivision of Respiratory Medicine, Department of Internal Medicine, Toho University Ohashi Medical Center, Tokyo, Japan.
Takatomo HirouchiDivision of Respiratory Medicine, Department of Internal Medicine, Toho University Ohashi Medical Center, Tokyo, Japan.
Shohei MakinoDivision of Anesthesiology, Department of Surgery Related, Kobe University Graduate School of Medicine, Kobe, Japan.
Moritoki EgiDivision of Anesthesiology, Department of Surgery Related, Kobe University Graduate School of Medicine, Kobe, Japan.
Yosuke OmaeGenome Medical Science Project (Toyama), National Center for Global Health and Medicine, Tokyo, Japan.
Yasuhito NannyaDepartment of Pathology and Tumor Biology, Kyoto University, Kyoto, Japan.
Takafumi UenoDepartment of Biomolecular Engineering, Graduate School of Tokyo Institute of Technology, Tokyo, Japan.ORCID 0000-0001-9219-0726
Tomomi TakanoLaboratory of Veterinary Infectious Disease, School of Veterinary Medicine, Kitasato University, Aomori, Japan.
Kazuhiko KatayamaLaboratory of Viral Infection, Department of Infection Control and Immunology, Ōmura Satoshi Memorial Institute & Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan.ORCID 0000-0002-7692-1151
Masumi AiDepartment of Insured Medical Care Management, Tokyo Medical and Dental University Hospital of Medicine, Tokyo, Japan.
Atsushi KumanogohDepartment of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Japan.ORCID 0000-0003-4749-7117
Toshiro SatoDepartment of Organoid Medicine, Keio University School of Medicine, Tokyo, Japan.ORCID 0000-0001-8353-8137
Naoki HasegawaDepartment of Infectious Diseases, Keio University School of Medicine, Tokyo, Japan.
Katsushi TokunagaGenome Medical Science Project (Toyama), National Center for Global Health and Medicine, Tokyo, Japan.ORCID 0000-0001-5501-0503
Makoto IshiiDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.ORCID 0000-0003-4396-1664
Ryuji KoikeMedical Innovation Promotion Center, Tokyo Medical and Dental University, Tokyo, Japan.
Yuko KitagawaDepartment of Surgery, Keio University School of Medicine, Tokyo, Japan.
Akinori KimuraInstitute of Research, Tokyo Medical and Dental University, Tokyo, Japan.
Seiya ImotoDivision of Health Medical Intelligence, Human Genome Center, the Institute of Medical Science, the University of Tokyo, Tokyo, Japan.ORCID 0000-0002-2989-308X
Satoru Miyano *M&D Data Science Center, Tokyo Medical and Dental University, Tokyo, Japan.
Seishi Ogawa *Department of Pathology and Tumor Biology, Kyoto University, Kyoto, Japan.ORCID 0000-0002-7778-5374
Takanori Kanai *Keio University Health Center, Tokyo, Japan.ORCID 0000-0002-1466-4532
Koichi Fukunaga *Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Yukinori Okada *Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan. yokada@sg.med.osaka-u.ac.jp.ORCID 0000-0002-0311-8472
Keio University · JPThe University of Osaka · JPTokyo Medical and Dental University · JPJapan Community Healthcare Organization · JPShowa University · JPJuntendo University · JPSaitama Prefecture · JPKansai Medical University · JPSaiseikai Nakatsu Hospital · JPSt. Marianna University School of Medicine · JPSaiseikai Utsunomiya hospital · JPTachikawa Hospital · JPTohoku University · JPTokyo Medical and Dental University Hospital · JPFujisawa City Hospital · JPJapan Anti Tuberculosis Association · JPKawasaki Municipal Hospital · JPSaitama Municipal Hospital · JPTosei General Hospital · JPKanazawa Medical Center · JP
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coronavirus disease 2019 (COVID-19) is a recently-emerged infectious disease that has caused millions of deaths, where comprehensive understanding of disease mechanisms is still unestablished. In particular, studies of gene expression dynamics and regulation landscape in COVID-19 infected individuals are limited. Here, we report on a thorough analysis of whole blood RNA-seq data from 465 genotyped samples from the Japan COVID-19 Task Force, including 359 severe and 106 non-severe COVID-19 cases. We discover 1169 putative causal expression quantitative trait loci (eQTLs) including 34 possible colocalizations with biobank fine-mapping results of hematopoietic traits in a Japanese population, 1549 putative causal splice QTLs (sQTLs; e.g. two independent sQTLs at TOR1AIP1), as well as biologically interpretable trans-eQTL examples (e.g., REST and STING1), all fine-mapped at single variant resolution. We perform differential gene expression analysis to elucidate 198 genes with increased expression in severe COVID-19 cases and enriched for innate immune-related functions. Finally, we evaluate the limited but non-zero effect of COVID-19 phenotype on eQTL discovery, and highlight the presence of COVID-19 severity-interaction eQTLs (ieQTLs; e.g., CLEC4C and MYBL2). Our study provides a comprehensive catalog of whole blood regulatory variants in Japanese, as well as a reference for transcriptional landscapes in response to COVID-19 infection.
Indexed as
COVID-19Genome-Wide Association StudyHumansJapanLectins, C-TypeMembrane GlycoproteinsPolymorphism, Single NucleotideQuantitative Trait LociReceptors, ImmunologicCLEC4C protein, humanLectins, C-TypeMembrane GlycoproteinsReceptors, Immunologic
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