ArticleNature communications2022
Whole Genome Association Study of the Plasma Metabolome Identifies Metabolites Linked to Cardiometabolic Disease in Black Individuals.
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Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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40citing papers in PubMed
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40 citing papers in PubMed, 60 citations in OpenAlex.
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- Merging metabolomics and genomics provides a catalog of genetic factors that influence molecular phenotypes in pigs linking relevant metabolic pathways.Genetics, selection, evolution : GSE · 2025Article
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- Multi-ancestry genome-wide association analyses: a comparison of meta- and mega-analyses in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study.BMC genomics · 2025Article
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Authors and funding
40 authors at 20 institutions in 5 countries.
Usman A Tahir *Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, US.
Daniel H Katz *Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, US.
Julian Avila-Pachecho *Broad Institute of Harvard and MIT, Cambridge, MA, US.ORCID 0000-0001-9388-3946
Alexander G BickBroad Institute of Harvard and MIT, Cambridge, MA, US.ORCID 0000-0001-5824-9595
Akhil PampanaBroad Institute of Harvard and MIT, Cambridge, MA, US.ORCID 0000-0002-4167-0540
Jeremy M RobbinsDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, US.
Zhi YuBroad Institute of Harvard and MIT, Cambridge, MA, US.ORCID 0000-0003-4810-3474
Zsu-Zsu ChenDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, US.
Mark D BensonDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, US.
Daniel E CruzDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, US.
Debby NgoDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, US.
Shuliang DengDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, US.
Xu ShiDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, US.
Shuning ZhengDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, US.
Aaron S EismanDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, US.ORCID 0000-0001-7609-1488
Laurie FarrellDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, US.
Michael E HallUniversity of Mississippi Medical Center, Jackson, MS, US.
Adolfo CorreaUniversity of Mississippi Medical Center, Jackson, MS, US.ORCID 0000-0002-9501-600X
Russell P TracyDepartment of Pathology Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, VT, US.ORCID 0000-0002-0080-2420
Peter DurdaDepartment of Pathology Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, VT, US.
Kent D TaylorThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor UCLA Medical Center, Torrance, CA, US.
Yongmei LiuDepartment of Medicine, Division of Cardiology, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, US.
W Craig JohnsonDepartment of Biostatistics, University of Washington, Seattle, WA, US.ORCID 0000-0002-3161-3753
Xiuqing GuoThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor UCLA Medical Center, Torrance, CA, US.ORCID 0000-0002-5264-5068
Jie YaoThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor UCLA Medical Center, Torrance, CA, US.
Yii-Der Ida ChenThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor UCLA Medical Center, Torrance, CA, US.
Ani W ManichaikulCenter for Public Health Genomics, University of Virginia, Charlottesville, Virginia, US.
Frederick L RubergSection of Cardiovascular Medicine, Boston University School of Medicine and Boston Medical Center, Boston, MA, US.
William S BlanerColumbia University Medical Center, New York, NY, US.ORCID 0000-0002-9847-7506
Deepti JainUniversity of Washington, Seattle, Washington, US.
NHLBI Trans-Omics for Precision Medicine 1 Consortium
Claude BouchardHuman Genomic Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, US.ORCID 0000-0002-0048-491X
Mark A SarzynskiDepartment of Exercise Science, University of South Carolina, Columbia, SC, US.ORCID 0000-0001-6705-0668
Stephen S RichCenter for Public Health Genomics, University of Virginia, Charlottesville, Virginia, US.ORCID 0000-0003-3872-7793
Jerome I RotterThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor UCLA Medical Center, Torrance, CA, US.
Thomas J WangDepartment of Medicine, UT Southwestern Medical Center, Dallas, TX, US.
James G WilsonDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, US.
Clary B Clish *Broad Institute of Harvard and MIT, Cambridge, MA, US.ORCID 0000-0001-8259-9245
Pradeep Natarajan *Broad Institute of Harvard and MIT, Cambridge, MA, US.
Robert E Gerszten *Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, US. rgerszte@bidmc.harvard.edu.ORCID 0000-0002-6767-7687
University of Washington · USUniversity of Maryland, Baltimore · USBrigham and Women's Hospital · USBaylor College of Medicine · USUniversity of Colorado Denver · USUniversity of Michigan · USJohns Hopkins University · USBroad Institute · USBeth Israel Deaconess Medical Center · USNew York Genome Center · USNational Institutes of Health · USBoston University · USStanford University · USUniversity of Pittsburgh · USWashington University in St. Louis · USEmory University · USHarvard University · USThe University of Texas Rio Grande Valley · USUniversity of Mississippi · USUniversity of Virginia · US
Funding
Large Scale Sequencing and Analysis of GenomesU54HG003067 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY, LANDER, ERIC S · 2004 to 2015
$568.6MUCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1MInstitute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4MUNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3MWake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3MClinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2MTask Area A Core Study Operations.Task Area A shall encompass annual follow-up of cohort members, clinical endpoints ascertainment, study coordination activities, maintenance of the database and biosp75N92020D00001 · NHLBI · UNIVERSITY OF WASHINGTON · PI MCCLELLAND, ROBYN LEAGH · 2020 to 2025
$17.2MPolygenic Risk Scores for Diverse Populations - Bridging Research and Clinical CareR01HL151152 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Christy Leigh Avery, Jennifer Below · 2020 to 2026
$12.3MStudies of Rare Genetic Variation in the Isolated Population of SardiniaR01HL117626 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ABECASIS, GONCALO · 2013 to 2016
$10.5MCHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5MMetabolomic predictors of insulin resistance and diabetesR01DK081572 · NIDDK · VANDERBILT UNIVERSITY · PI CLISH, CLARY B, GERSZTEN, ROBERT E · 2008 to 2025
$9.3MBLRD VA I01 BX005831CSRD VA I01 CX001737NCATS NIH HHS KL2 TR002542NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NCATS NIH HHS UL1 TR001881NCI NIH HHS T32 CA154274NHGRI NIH HHS U54 HG003067NHLBI NIH HHS 75N92020D00001NHLBI NIH HHS 75N92020D00002NHLBI NIH HHS 75N92020D00003NHLBI NIH HHS 75N92020D00004NHLBI NIH HHS 75N92020D00005NHLBI NIH HHS 75N92020D00006NHLBI NIH HHS 75N92020D00007NHLBI NIH HHS HHSN268201100037CNHLBI NIH HHS HHSN268201500003CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS HHSN268201800010INHLBI NIH HHS HHSN268201800011CNHLBI NIH HHS HHSN268201800011INHLBI NIH HHS HHSN268201800012CNHLBI NIH HHS HHSN268201800012INHLBI NIH HHS HHSN268201800014CNHLBI NIH HHS HHSN268201800014INHLBI NIH HHS HHSN268201800015INHLBI NIH HHS K08 HL141601NHLBI NIH HHS K08 HL145095NHLBI NIH HHS K08 HL161445NHLBI NIH HHS K23 HL150327NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS R01 HL045670NHLBI NIH HHS R01 HL047317NHLBI NIH HHS R01 HL047323NHLBI NIH HHS R01 HL047327NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL117626NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01 HL127564NHLBI NIH HHS R01 HL135242NHLBI NIH HHS R01 HL139671NHLBI NIH HHS R01 HL142711NHLBI NIH HHS R01 HL146462NHLBI NIH HHS R01 HL148050NHLBI NIH HHS R01 HL148565NHLBI NIH HHS R01 HL151152NHLBI NIH HHS R01 HL151283NHLBI NIH HHS T32 HL007374NHLBI NIH HHS U01 HL120393NIAAA NIH HHS R21 AA028110NIA NIH HHS K01 AG059898NIDDK NIH HHS K23 DK127073NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK068437NIDDK NIH HHS R01 DK081572NIEHS NIH HHS P30 ES010126NIGMS NIH HHS P30 GM118430NIH HHS S10 OD026880NIH HHS S10 OD030463NIMHD NIH HHS HHSN268201800013ININR NIH HHS R01 NR019628
Abstract
Integrating genetic information with metabolomics has provided new insights into genes affecting human metabolism. However, gene-metabolite integration has been primarily studied in individuals of European Ancestry, limiting the opportunity to leverage genomic diversity for discovery. In addition, these analyses have principally involved known metabolites, with the majority of the profiled peaks left unannotated. Here, we perform a whole genome association study of 2,291 metabolite peaks (known and unknown features) in 2,466 Black individuals from the Jackson Heart Study. We identify 519 locus-metabolite associations for 427 metabolite peaks and validate our findings in two multi-ethnic cohorts. A significant proportion of these associations are in ancestry specific alleles including findings in APOE, TTR and CD36. We leverage tandem mass spectrometry to annotate unknown metabolites, providing new insight into hereditary diseases including transthyretin amyloidosis and sickle cell disease. Our integrative omics approach leverages genomic diversity to provide novel insights into diverse cardiometabolic diseases.
Indexed as
Cardiovascular DiseasesGenome-Wide Association StudyBlack PeopleHumansMetabolomeMetabolomicsTandem Mass Spectrometry
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