Evidence map›Paper›PMID 35995657›Full record

ArticlePancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]2022

Endoplasmic stress-inducing variants in carboxyl ester lipase and pancreatic cancer risk.

Makoto Kawamoto, Takeichi Yoshida, Koji Tamura, Mohamad Dbouk, Marcia Irene Canto, Richard Burkhart, Jin He, Nicholas J Roberts, Alison P Klein, Michael Goggins

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Makoto KawamotoDepartment of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Takeichi YoshidaDepartment of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Koji TamuraDepartment of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Mohamad DboukDepartment of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Marcia Irene CantoMedicine, Johns Hopkins Medical Institutions, Baltimore, MD, USA; Oncology, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Richard BurkhartSurgery, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Jin HeSurgery, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Nicholas J RobertsDepartment of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA; Oncology, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Alison P KleinDepartment of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA; Oncology, Johns Hopkins Medical Institutions, Baltimore, MD, USA; The Sol Goldman Pancreatic Cancer Research Center, And the Bloomberg School of Public Health, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Michael GogginsDepartment of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA; Medicine, Johns Hopkins Medical Institutions, Baltimore, MD, USA; Oncology, Johns Hopkins Medical Institutions, Baltimore, MD, USA. Electronic address: mgoggins@jhmi.edu.
Johns Hopkins University · US

Funding

Tumor Antigens for Individual Signatures and TherapyP50CA062924 · NCI · JOHNS HOPKINS UNIVERSITY · PI THOMPSON, ELIZABETH D · 1993 to 2022
$54.6M
Using markers to improve pancreatic cancer screening and surveillance: a multi-center studyU01CA210170 · NCI · JOHNS HOPKINS UNIVERSITY · PI Michael G. Goggins · 2016 to 2026
$9.3M
Validation and Fine-Scale Mapping of Pancreatic Cancer Susceptibility Loci (Study)R01CA154823 · NCI · JOHNS HOPKINS UNIVERSITY · PI KLEIN, ALISON P · 2011 to 2020
$5.7M
Using Markers to Improve Pancreatic Cancer ScreeningR01CA176828 · NCI · JOHNS HOPKINS UNIVERSITY · PI GOGGINS, MICHAEL G. · 2013 to 2024
$4.1M
1/2 Rare Bipolar Loci identification through Synaptome SequencingR01MH087979 · NIMH · UNIVERSITY OF IOWA · PI POTASH, JAMES B. · 2010 to 2014
$2.0M
NCI NIH HHS P50 CA062924NCI NIH HHS R01 CA154823NCI NIH HHS R01 CA176828NCI NIH HHS U01 CA210170NIMH NIH HHS R01 MH087979
6 · The paper itself

Abstract

backgroundEndoplasmic reticulum (ER) stress-inducing variants in several pancreatic secretory enzymes have been associated with pancreatic disease. Multiple variants in CEL, encoding carboxyl ester lipase, are known to cause maturity-onset diabetes of the young (MODY8) but have not been implicated in pancreatic cancer risk.

methodsThe prevalence of ER stress-inducing variants in the CEL gene was compared among pancreatic cancer cases vs. controls. Variants were identified by next-generation sequencing and confirmed by Sanger sequencing. Variants of uncertain significance (VUS) were assessed for their effect on the secretion of CEL protein and variants with reduced protein secretion were evaluated to determine if they induced endoplasmic reticulum stress.

resultsER stress-inducing CEL variants were found in 34 of 986 cases with sporadic pancreatic ductal adenocarcinoma, and 21 of 1045 controls (P = 0.055). Most of the variants were either the CEL-HYB1 variant, the I488T variant, or the combined CEL-HYB1/I488T variant; one case had a MODY8 variant.

conclusionThis case/control analysis finds ER stress-inducing CEL variants are not associated with an increased likelihood of having pancreatic cancer.

Indexed as

CarboxylesterasePancreatic NeoplasmsDiabetes Mellitus, Type 2Endoplasmic Reticulum StressEstersHumansLipasePancreasPancreatic HormonesCarboxylesteraseEstersLipasePancreatic HormonesCELEndoplasmic reticulum stressInherited susceptibilityPancreatic cancerVariant

Identifiers

PMID35995657
PMCPMC9669157
OpenAlexW4292086448

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.