ReviewTrends in neurosciences2022
Prefrontal cortex as a key node in arousal circuitry.
Review in Trends in neurosciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed.
- Effects of high-definition transcranial direct current stimulation for the treatment of chronic insomnia: a randomized, double-blind, controlled trial.Scientific reports · 2025Trial
- Anesthesia-induced electroencephalogram oscillations and perioperative outcomes in older adults undergoing cardiac surgery.Journal of clinical anesthesia · 2025Trial
- Top-down control of sustained attention by medial prefrontal cortex-locus coeruleus (mPFC-LC) projection neurons during the rodent continuous performance test (rCPT).Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Article
- Anesthesia unconsciousness recruits dynamic parabrachial activity within a distributed brain-wide ensemble.bioRxiv : the preprint server for biology · 2026Article
- Association of maternal alcohol consumption with frequent nocturnal enuresis in offspring.European child & adolescent psychiatry · 2026Article
- Brain-wide mapping and region-specific cellular characterization of Trhr1 reporter-labeled cells in mice using VISoR imaging.Brain structure & function · 2026Article
- Subcortical recruitment dissociates isoflurane emergence from distinct wakeful states in mice.bioRxiv : the preprint server for biology · 2026Article
- Behavioral state-dependent norepinephrine dynamics in the primary somatosensory and prefrontal cortices during tactile detection tasks.bioRxiv : the preprint server for biology · 2026Article
- Bridging mental health, cognition and the brain in mild traumatic brain injury: A multilayer network analysis of the TRACK-TBI study.NeuroImage. Clinical · 2026Article
- Ensembles and engrams in mouse cortical and sub-thalamic brain regions supporting context and memory recall.Neurobiology of learning and memory · 2026Article
- A Dual-Mode Wireless Microsystem for Monitoring Dopamine and Spike Changes with Dexmedetomidine.Cyborg and bionic systems (Washington, D.C.) · 2026Article
- The night shift brain: functional network reorganization in sleep-deprived medical staff.Frontiers in human neuroscience · 2026Article
- Non-invasive neuroregulation techniques applied to patients with consciousness disorders: a narrative review.Frontiers in human neuroscience · 2026Review
- Top-down control of sustained attention by the medial prefrontal cortex (mPFC) - locus coeruleus (LC) circuit during the rodent continuous performance test (rCPT).bioRxiv : the preprint server for biology · 2025Article
- The anterior paraventricular thalamus counteracts fear expression during retrieval through both amygdala and subiculum circuits.Communications biology · 2025Article
- Convergent Control of NREM Sleep and Anesthesia by Prefrontal Layer 5 Extratelencephalic Neurons.Research square · 2025Article
- Simultaneous EEG-PET-MRI identifies temporally coupled and spatially structured brain dynamics across wakefulness and NREM sleep.Nature communications · 2025Article
- Transcranial direct current stimulation modulates primate brain dynamics across states of consciousness.eLife · 2025Article
- Association between pyramidal neurone spiking in the medial prefrontal cortex and the sedative potency of volatile anaesthetics in mice.British journal of anaesthesia · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The role of the prefrontal cortex (PFC) in the mechanism of consciousness is a matter of active debate. Most theoretical and empirical investigations have focused on whether the PFC is critical for the content of consciousness (i.e., the qualitative aspects of conscious experience). However, there is emerging evidence that, in addition to its well-established roles in cognition, the PFC is a key regulator of the level of consciousness (i.e., the global state of arousal). In this opinion article we review recent data supporting the hypothesis that the medial PFC is a critical node in arousal-promoting networks.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.