ArticleNeurology2022
Novelty-Related fMRI Responses of Precuneus and Medial Temporal Regions in Individuals at Risk for Alzheimer Disease.
Registry-linked trialOpen access · hybridAbstract read
In one paragraph
Article in Neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06284720 (Transcranial Alternating Current Stimulation for the Improvement of Episodic Memory in Healthy Older Adults), which is not on this map. Cited by 38 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
10.1field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Transcranial Alternating Current Stimulation for the Improvement of Episodic Memory in Healthy Older Adults
Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- Translation of task-evoked negative BOLD response into aging and Alzheimer's disease: a systematic review of the current literature.Journal of translational medicine · 2025Pooled it
- Disruption of temporo-parietal network in Alzheimer's disease and its association with memory impairment.Alzheimer's research & therapy · 2026Observational
- Maintaining and regaining episodic memory in Alzheimer disease: a circuit-based perspective.Nature reviews. Neurology · 2026Review
- Dysfunction of the episodic memory network in the Alzheimer's disease cascade.Nature communications · 2026Article
- Vascular and Neural Transcriptomics Reveal Stage-Dependent Pathways to Inflammation and Cognitive Dysfunction in a Rat Model of Hypertension.Journal of the American Heart Association · 2026Article
- Multiscale dispersion entropy of resting-state EEG in older adults with Alzheimer's disease, mild cognitive impairment, and remitted major depressive disorder.Journal of Alzheimer's disease : JAD · 2026Article
- Functional neuroanatomy of musical object processing in Alzheimer's disease and frontotemporal dementia.Brain communications · 2026Article
- Sex-specific gray matter underpinnings of anxiety and their mediating mechanisms inFrontiers in aging neuroscience · 2026Article
- Substantia Nigra MRI markers are lower in Alzheimer's disease and are linked to general cognitive function.Brain communications · 2026Article
- Understanding quantitative effects of anti-amyloid therapies on tau biomarkers and functional outcome. Insights from a comprehensive mechanistic quantitative systems pharmacology study.Frontiers in pharmacology · 2026Article
- Hippocampal formation-cortical high-fidelity memory networks in healthy older adults during the mnemonic discrimination task.Frontiers in aging neuroscience · 2026Article
- Dual transcranial electromagnetic stimulation of the precuneus boosts human long-term memory.eLife · 2025Article
- Differential Speed and Accuracy Trade-Off in Working Memory Retrieval and Bilateral Precuneus Between Older Men and Women.Brain and behavior · 2025Article
- Beyond binary classification: Comparing three region-based multi-phase Aβ staging systems.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Precuneus Activity during Retrieval Is Positively Associated with Amyloid Burden in Cognitively Normal OlderThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Hubs, influencers, and communities of executive functions: a task-based fMRI graph analysis.Frontiers in human neuroscience · 2025Article
- Deep linear matrix approximate reconstruction with integrated BOLD signal denoising reveals reproducible hierarchical brain connectivity networks from multiband multi-echo fMRI.Frontiers in neuroscience · 2025Article
- Specificity of functional network connectivity during the AD prodromal phase in mild cognitive impairment.Frontiers in psychiatry · 2025Article
- Cognitive reserve against Alzheimer's pathology is linked to brain activity during memory formation.Nature communications · 2024Observational
- Single-value brain activity scores reflect both severity and risk across the Alzheimer's continuum.Brain : a journal of neurology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
48 authors at 1 institution in 1 country.
Ornella V BilletteFrom the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.
Gabriel ZieglerFrom the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.
Merita AruciFrom the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.
Hartmut SchützeFrom the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.
Jasmin M KizilirmakFrom the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.
Anni RichterFrom the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.ORCID 0000-0001-9681-6298
Slawek AltensteinFrom the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.
Claudia BartelsFrom the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.
Frederic BrosseronFrom the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.ORCID 0000-0003-3137-7516
Arturo Cardenas-BlancoFrom the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.ORCID 0000-0001-8683-8741
Philip DahmenFrom the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.
Peter DechentFrom the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.
Laura DobischFrom the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.
Klaus FliessbachFrom the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.
Silka Dawn FreieslebenFrom the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.
Wenzel GlanzFrom the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.ORCID 0000-0002-5865-4176
Doreen GöerßFrom the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.
John Dylan HaynesFrom the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.
Michael T HenekaFrom the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.
Ingo KilimannFrom the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.
Okka KimmichFrom the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.
Luca KleineidamFrom the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.
Christoph LaskeFrom the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.
Andrea LohseFrom the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.
Ayda RostamzadehFrom the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.
Coraline MetzgerFrom the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.
Matthias H MunkFrom the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.
Oliver PetersFrom the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.
Lukas PreisFrom the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.
Josef PrillerFrom the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.
Klaus SchefflerFrom the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.ORCID 0000-0001-6316-8773
Anja SchneiderFrom the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.
Annika SpottkeFrom the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.
Eike Jakob SpruthFrom the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.
Alfredo RamirezFrom the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.
Sandra RöskeFrom the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.
Nina RoyFrom the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.
Stefan TeipelFrom the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.
Michael WagnerFrom the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.ORCID 0000-0003-2589-6440
Jens WiltfangFrom the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.
Steffen WolfsgruberFrom the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.
Renat YakupovFrom the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.ORCID 0000-0002-3868-284X
Peter ZeidmanFrom the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.
Frank JessenFrom the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.
Björn H SchottFrom the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.ORCID 0000-0002-8237-4481
Emrah DüzelFrom the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK.
Anne MaassFrom the German Center for Neurodegenerative Diseases (DZNE) (O.V.B., G.Z., M.A., A.C.-B., W.G., C.M., R.Y., E.D., A.M.), Magdeburg; Institute of Cognitive Neurology and Dementia Research (IKND) (O.V.B., G.Z., H.S., A.C.-B., L.D., C.M., R.Y., E.D.), Otto-von-Guericke University, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (J.M.K., J.W., B.H.S.), Goettingen; Department of Behavioral Neurology (A. Richter, B.H.S.), Leibniz Institute for Neurobiology, Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.A., P. Dahmen, S.D.F., O.P., L.P., J.P., E.J.S.), Berlin; Department of Psychiatry and Psychotherapy (S.A., A.L., J.P., E.J.S.), Charité; Department of Psychiatry and Psychotherapy (C.B., J.W., B.H.S.), University Medical Center Goettingen, University of Goettingen; German Center for Neurodegenerative Diseases (DZNE) (F.B., K.F., M.T.H., O.K., L.K., A. Schneider, A. Spottke, A. Ramirez, S.R., N.R., M.W., S.W., F.J.), Bonn; University of Bonn Medical Center (F.B., K.F., M.T.H., L.K., A. Schneider, A. Ramirez, M.W., S.W.); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, Bonn; MR-Research in Neurosciences (P. Dechent), Department of Cognitive Neurology, Georg-August-University Göttingen; Department of Psychosomatic Medicine (D.G., I.K., S.T.), Rostock University Medical Center; Bernstein Center for Computational Neuroscience (J.D.H.), Charité-Universitätsmedizin, Berlin; German Center for Neurodegenerative Diseases (DZNE) (I.K., S.T.), Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.L., M.H.M.), Tübingen; Section for Dementia Research (C.L.), Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen; Department of Psychiatry (A. Rostamzadeh), Medical Faculty, University of Cologne; Department of Psychiatry and Psychotherapy (C.M.), Otto-von-Guericke University, Magdeburg; Systems Neurophysiology (M.H.M.), Department of Biology, Darmstadt University of Technology, Germany; Campus Benjamin Franklin, Department of Psychiatry (O.P, L.P.), Charité-Universitätsmedizin Berlin; Department for Biomedical Magnetic Resonance (K.S.), University of Tübingen; Department of Neurology (A. Spottke), University of Bonn; Division of Neurogenetics and Molecular Psychiatry (A. Ramirez, F.J.), Department of Psychiatry, Medical Faculty, University of Cologne; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) (A. Ramirez, F.J.), University of Cologne, Köln, Germany; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (A. Ramirez), San Antonio, TX; Neurosciences and Signaling Group (J.W.), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Portugal; and Wellcome Centre for Human Neuroimaging (P.Z.), London, UK. annemaass85@gmx.de.
DELCODE Study Group
German Center for Neurodegenerative Diseases · DE
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesWe assessed whether novelty-related fMRI activity in medial temporal lobe regions and the precuneus follows an inverted U-shaped pattern across the clinical spectrum of increased Alzheimer disease (AD) risk as previously suggested. Specifically, we tested for potentially increased activity in individuals with a higher AD risk due to subjective cognitive decline (SCD) or mild cognitive impairment (MCI). We further tested whether activity differences related to diagnostic groups were accounted for by CSF markers of AD or brain atrophy.
methodsWe studied 499 participants aged 60-88 years from the German Center for Neurodegenerative Diseases Longitudinal Cognitive Impairment and Dementia Study (DELCODE) who underwent task-fMRI. Participants included 163 cognitively normal (healthy control, HC) individuals, 222 SCD, 82 MCI, and 32 patients with clinical diagnosis of mild AD. CSF levels of β-amyloid 42/40 ratio and phosphorylated-tau181 were available from 232 participants. We used region-based analyses to assess novelty-related activity (novel > highly familiar scenes) in entorhinal cortex, hippocampus, and precuneus as well as whole-brain voxel-wise analyses. First, general linear models tested differences in fMRI activity between participant groups. Complementary regression models tested quadratic relationships between memory impairment and activity. Second, relationships of activity with AD CSF biomarkers and brain volume were analyzed. Analyses were controlled for age, sex, study site, and education.
resultsIn the precuneus, we observed an inverted U-shaped pattern of novelty-related activity across groups, with higher activity in SCD and MCI compared with HC, but not in patients with AD who showed relatively lower activity than MCI. This nonlinear pattern was confirmed by a quadratic relationship between memory impairment and precuneus activity. Precuneus activity was not related to AD biomarkers or brain volume. In contrast to the precuneus, hippocampal activity was reduced in AD dementia compared with all other groups and related to AD biomarkers. DISCUSSION: Novelty-related activity in the precuneus follows a nonlinear pattern across the clinical spectrum of increased AD risk. Although the underlying mechanism remains unclear, increased precuneus activity might represent an early signature of memory impairment. Our results highlight the nonlinearity of activity alterations that should be considered in clinical trials using functional outcome measures or targeting hyperactivity.
Indexed as
Alzheimer DiseaseCognitive DysfunctionAmyloid beta-PeptidesBiomarkersHumansMagnetic Resonance ImagingParietal LobeTemporal LobeAmyloid beta-PeptidesBiomarkers
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Registered trials
NCT06284720ClinicalTrials.gov
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