Evidence map›Paper›PMID 35995507›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2022

Disruption of Nurse-like Cell Differentiation as a Therapeutic Strategy for Chronic Lymphocytic Leukemia.

Giovanna Merchand-Reyes, Ramasamy Santhanam, Frank H Robledo-Avila, Christoph Weigel, Juan de Dios Ruiz-Rosado, Xiaokui Mo, Santiago Partida-Sánchez, Jennifer A Woyach, Christopher C Oakes, Susheela Tridandapani and 1 more

Open access · greenAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Giovanna Merchand-ReyesDivision of Hematology, The Ohio State University College of Medicine, Columbus, OH; giovanna.merchandreyes@osumc.edu jon.butchar@osumc.edu.
Ramasamy SanthanamDivision of Hematology, The Ohio State University College of Medicine, Columbus, OH.ORCID http://orcid.org/0000-0002-8471-1699
Frank H Robledo-AvilaNationwide Children's Hospital, Columbus, OH; and.ORCID http://orcid.org/0000-0001-5583-9194
Christoph WeigelDivision of Hematology, The Ohio State University College of Medicine, Columbus, OH.
Juan de Dios Ruiz-RosadoNationwide Children's Hospital, Columbus, OH; and.ORCID http://orcid.org/0000-0002-6429-9086
Xiaokui MoCenter for Biostatistics, The Ohio State University College of Medicine, Columbus, OH.ORCID http://orcid.org/0000-0002-9797-2687
Santiago Partida-SánchezNationwide Children's Hospital, Columbus, OH; and.
Jennifer A WoyachDivision of Hematology, The Ohio State University College of Medicine, Columbus, OH.
Christopher C OakesDivision of Hematology, The Ohio State University College of Medicine, Columbus, OH.
Susheela TridandapaniDivision of Hematology, The Ohio State University College of Medicine, Columbus, OH.
Jonathan P ButcharDivision of Hematology, The Ohio State University College of Medicine, Columbus, OH; giovanna.merchandreyes@osumc.edu jon.butchar@osumc.edu.
The Ohio State University · USNationwide Children's Hospital · US

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Jennifer A. Woyach · 1985 to 2026
$132.3M
Myeloid cell-derived Granzyme B as an inducible enhancer of cancer immunotherapyR01CA203584 · NCI · OHIO STATE UNIVERSITY · PI BUTCHAR, JONATHAN P., TRIDANDAPANI, SUSHEELA · 2017 to 2021
$1.7M
Novel monocyte effector function in CLL immune therapyR01CA162411 · NCI · OHIO STATE UNIVERSITY · PI BYRD, JOHN C., TRIDANDAPANI, SUSHEELA · 2013 to 2017
$1.6M
NCI NIH HHS P30 CA016058NCI NIH HHS R01 CA162411NCI NIH HHS R01 CA203584
6 · The paper itself

Abstract

Chronic lymphocytic leukemia (CLL) is the most common adult leukemia, but, despite advances in treatment, many patients still experience relapse. CLL cells depend on interactions with supportive cells, and nurse-like cells (NLCs) are the major such cell type. However, little is known about how NLCs develop. Here, we performed DNA methylation analysis of CLL patient-derived NLCs using the 850K Illumina array, comparing CD14

Indexed as

Leukemia, Lymphocytic, Chronic, B-CellAnimalsCell DifferentiationMiceMitogen-Activated Protein Kinase KinasesMonocytesTranscription Factor AP-1Mitogen-Activated Protein Kinase KinasesTranscription Factor AP-1

Identifiers

PMID35995507
PMCPMC9492647
OpenAlexW4293276295

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.