ArticleIndian heart journal
Premature coronary artery disease, risk factors, clinical presentation, angiography and interventions: Hospital based registry.
Article in Indian heart journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Risk factors, lab parameters, angiographic characteristics and outcomes of coronary artery disease in young South Asian patients: a systematic review.The Journal of international medical research · 2023Pooled it
- Association Between Fruits and Vegetables Consumption and Premature Coronary Artery Disease (PCAD): A Multi-Center Case Control Study.Food science & nutrition · 2026Article
- Periodontal Dysbiosis and Premature Atherosclerosis: A Critical Appraisal of the Oral-Gut-Vascular Axis.Biomedicines · 2026Review
- Expert consensus on Lipoprotein(a) in the Gulf countries: Navigating cardiovascular risk and therapeutic advances.Atherosclerosis plus · 2026Article
- Temporal Trends in Lipid-Lowering Therapy Use and Adherence in Patients With Premature Coronary Artery Disease.Journal of the American Heart Association · 2026Article
- Article
- Role of homocysteine, vitamins B12, B6, B1, and folate in Saudi patients with premature acute coronary syndrome.Frontiers in medicine · 2026Article
- Apolipoprotein E ε3/ε4 and coronary artery disease: lipid and non-lipid mechanisms in personalized prevention - narrative review.Frontiers in cardiovascular medicine · 2026Review
- A Hybrid Chart Review of Premature Coronary Artery Disease: An Opportunity to Improve Diagnostic Excellence and Management.The Permanente journal · 2025Article
- Chronic statin-use before PCI in acute coronary syndromes and in-hospital outcomes: ACC-NCDR registry in India.American journal of preventive cardiology · 2025Article
- Severe left main coronary artery disease and STEMI in a 19-year-old without traditional risk factors: A rare case of premature coronary artery disease.SAGE open medical case reports · 2025Article
- Changes in Serum PDGF-C and TGF-β1 Levels After PCI in Premature Coronary Artery Disease: Combined Predictive Value for MACCE.International journal of general medicine · 2025Article
- Is the prevalence of risk factors, clinical presentations and severity of coronary artery diseases (CAD) in patients with very early and premature CAD are different from mature CAD patients?: A registry- based cross-sectional study.Global epidemiology · 2024Article
- Apolipoprotein E E3/E4 genotype is associated with an increased risk of premature coronary artery disease.BMC cardiovascular disorders · 2024Article
- Observational
- Low body mass index is associated with adverse cardiovascular outcomes following PCI in India: ACC-NCDR registry.International journal of cardiology. Cardiovascular risk and prevention · 2024Article
- Long-Term Prognosis after ST-Elevation Myocardial Infarction in Patients with Premature Coronary Artery Disease.Journal of personalized medicine · 2024Article
- Correlation between remnant cholesterol and premature coronary artery disease and the severity of coronary artery lesions in men: a retrospective study.Frontiers in cardiovascular medicine · 2024Article
- Impact of premature coronary artery disease on adverse event risk followingFrontiers in cardiovascular medicine · 2023Article
- Epidemiological profile and clinical outcomes of very young (<35 years) and young (35-50 years) patients with STEMI: Insights from the NORIN STEMI registry.Indian heart journalObservational
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND &
aimsPremature coronary artery disease (CAD) is endemic in India. We performed a study to identify risk factors, clinical presentation, angiographic findings and interventions in premature CAD.
methodsSuccessive patients who underwent percutaneous intervention (PCI) were enrolled from January 2018 to June 2021. Premature CAD was defined as women 45-59 y and men 40-54 y and very premature as women <45 y and men <40 y. Descriptive statistics are presented. Univariate odds ratio (OR) and 95% confidence intervals (95%CI) were calculated to identify differences in various groups.
results4672 patients (women 936, men 3736) were enrolled. Premature CAD was in 1238 (26.5%; women 31.9%; men 25.1%) and very premature in 212 (4.5%; women 6.5%, men 4.0%). In premature and very premature vs non-premature CAD, OR (95%CI) for high cholesterol ≥200 mg/dl [women 1.52(1.03-2.25) and 1.59(0.79-3.20); men 1.73(1.38-2.17) and 1.92(1.22-3.03)], non-HDL cholesterol ≥130 mg/dl [women 1.84(1.35-2.52) and 1.32(0.72-2.42); men 1.69(1.43-1.90) and 1.67(1.17-2.34)], LDL cholesterol [men 1.10(0.95-1.25) and 1.04(0.77-1.41)], and tobacco [women 1.40(0.84-2.35) and 2.14(0.95-4.82); men 1.63(1.34-1.98) and 1.27(0.81-1.97)] were higher while hypertension, diabetes and chronic kidney disease were more in non-premature(p < 0.05). Presentation as STEMI was marginally more in women with premature [1.13(0.85-1.51)] and very premature [1.29(0.75-2.22)] CAD and was significantly higher in men [1.35(1.16-1.56) and 1.79(1.29-2.49)]. Location and extent of CAD were not different.
conclusionsIn India, a third of CAD patients presenting for coronary intervention have premature disease. Important risk factors are high total and non-HDL cholesterol and tobacco (men) with greater presentation as STEMI. Extent and type of CAD are similar to non-premature CAD indicating severe disease.
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