Evidence map›Paper›PMID 35995080›Full record

SynthesisNeuroscience and biobehavioral reviews2022

Effects of psychotropic drugs on ocular parameters relevant to traffic safety: A systematic review.

Thomas R Arkell, Ashley Brooks-Russell, Luke A Downey, Brook Shiferaw, Timothy Brown, James Sherrick, Amie C Hayley

Open access · greenAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Neuroscience and biobehavioral reviews, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Effect of CannEpilJournal of psychopharmacology (Oxford, England) · 2023
    Trial
  4. Pupillary dynamics as a marker of acute cannabis inhalation.Clinical toxicology (Philadelphia, Pa.) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Thomas R ArkellCentre for Human Psychopharmacology, Swinburne University of Technology, Hawthorn, Australia; Working Group for Driver Monitoring Systems (DMS), International Council for Alcohol, Drugs and Traffic Safety (ICADTS), the Netherlands.
Ashley Brooks-RussellInjury and Violence Prevention Center, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Luke A DowneyCentre for Human Psychopharmacology, Swinburne University of Technology, Hawthorn, Australia; Working Group for Driver Monitoring Systems (DMS), International Council for Alcohol, Drugs and Traffic Safety (ICADTS), the Netherlands; Institute for Breathing and Sleep, Austin Health, Melbourne, Australia.
Brook ShiferawCentre for Human Psychopharmacology, Swinburne University of Technology, Hawthorn, Australia; Working Group for Driver Monitoring Systems (DMS), International Council for Alcohol, Drugs and Traffic Safety (ICADTS), the Netherlands; Seeing Machines, Fyshwick, Australian Capital Territory, Australia.
Timothy BrownWorking Group for Driver Monitoring Systems (DMS), International Council for Alcohol, Drugs and Traffic Safety (ICADTS), the Netherlands; The National Advanced Driving Simulator, University of Iowa, Iowa City, IA, USA.
James SherrickInjury and Violence Prevention Center, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Amie C HayleyCentre for Human Psychopharmacology, Swinburne University of Technology, Hawthorn, Australia; Working Group for Driver Monitoring Systems (DMS), International Council for Alcohol, Drugs and Traffic Safety (ICADTS), the Netherlands; Institute for Breathing and Sleep, Austin Health, Melbourne, Australia. Electronic address: ahayley@swin.edu.au.
University of Colorado Anschutz Medical Campus · US

Funding

Novel approaches to assessing cannabis impaired drivingR01DA049800 · NIDA · UNIVERSITY OF COLORADO DENVER · PI BROOKS-RUSSELL, ASHLEY · 2020 to 2024
$2.6M
NIDA NIH HHS R01 DA049800
6 · The paper itself

Abstract

Driving is a complex neurobehavioural task necessitating the rapid selection, uptake, and processing of visual information. Eye movements that are critical for the execution of visually guided behaviour such as driving are also sensitive to the effects of psychotropic substances. The Embase (via Ovid), EBSCOHost, Psynet, Pubmed, Scopus and Web of Science databases were examined from January 01st, 2000 to December 31st, 2021. Study selection, data extraction and Cochrane Risk of Bias (RoB2) assessments were conducted according to PRISMA guidelines. The review was prospectively registered (CRD42021267554). In total, 36 full-text articles examined the effects of six principal psychotropic drug classes on measures of oculomotor parameters relevant to driving. Centrally depressing substances affect oculomotor responses in a dose-dependent manner. Psychostimulants improve maximal speed, but not accuracy, of visual search behaviours. Inhaled Δ-9-tetrahydrocannabinol (THC) increases inattention (saccadic inaccuracy) but does not consistently affect other oculomotor parameters. Alterations to composite ocular parameters due to psychoactive substance usage likely differently compromises performance precision during driving through impaired ability to select and process dynamic visual information.

Indexed as

DronabinolSaccadesEye MovementsHumansPsychotropic DrugsVision, OcularDronabinolPsychotropic DrugsDrivingEye movementPsychotropicSaccadeSmooth pursuitVisual

Identifiers

PMID35995080
PMCPMC10067018
OpenAlexW4293866515

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.