Evidence map›Paper›PMID 35995037›Full record

SynthesisDevelopmental neuroscience2022

Associations of Mitochondrial Function, Stress, and Neurodevelopmental Outcomes in Early Life: A Systematic Review.

Tingting Zhao, Nathan N Alder, Angela R Starkweather, Ming-Hui Chen, Adam P Matson, Wanli Xu, Jeremy L Balsbaugh, Xiaomei Cong

Open access · greenAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Developmental neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Tingting ZhaoSchool of Nursing, University of Connecticut, Storrs, Connecticut, USA, tingting.zhao@uconn.edu.
Nathan N AlderDepartment of Molecular and Cell Biology, University of Connecticut, Storrs, Connecticut, USA.
Angela R StarkweatherCollege of Nursing, University of Florida, Gainesville, Florida, USA.
Ming-Hui ChenDepartment of Statistics, University of Connecticut, Storrs, Connecticut, USA.
Adam P MatsonDivision of Neonatology, Connecticut Children's Medical Center, Hartford, Connecticut, USA.
Wanli XuSchool of Nursing, University of Connecticut, Storrs, Connecticut, USA.
Jeremy L BalsbaughProteomics and Metabolomics Facility, University of Connecticut, Storrs, Connecticut, USA.
Xiaomei CongSchool of Nursing, University of Connecticut, Storrs, Connecticut, USA.
University of Connecticut · USUniversity of Florida · US

Funding

Multi-Omics Analysis of Pain/Stress Impact on Neurodevelopment in Preterm InfantsR01NR016928 · NINR · UNIVERSITY OF CONNECTICUT STORRS · PI CONG, XIAOMEI SOPHIA · 2017 to 2020
$2.5M
Integrative omics analysis of pain/stress impact on mitochondrial function and neurodevelopment in preterm infantsF31NR019940 · NINR · UNIVERSITY OF CONNECTICUT STORRS · PI ZHAO, TINGTING · 2022 to 2022
$45k
NINR NIH HHS F31 NR019940NINR NIH HHS R01 NR016928
6 · The paper itself

Abstract

Early life stress is commonly experienced by infants, especially preterm infants, and may impact their neurodevelopmental outcomes in their early and later lives. Mitochondrial function/dysfunction may play an important role underlying the linkage of prenatal and postnatal stress and neurodevelopmental outcomes in infants. This review aimed to provide insights on the relationship between early life stress and neurodevelopment and the mechanisms of mitochondrial function/dysfunction that contribute to the neuropathology of stress. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement was used to develop this systematic review. PubMed, Scopus, PsycINFO, and Biosis databases were searched for primary research articles published between 2010 and 2021 that examined the relationships among mitochondrial function/dysfunction, infant stress, and neurodevelopment. Thirty studies were identified. There is evidence to support that mitochondrial function/dysfunction mediates the relationship between prenatal and postnatal stress and neurodevelopmental outcomes in infants. Maternal transgenerational transmission of mitochondrial bioenergetic patterns influenced prenatal stress induced neurodevelopmental outcomes and behavioral changes in infants. Multiple functionally relevant mitochondrial proteins, genes, and polymorphisms were associated with stress exposure. This is the first review of the role that mitochondrial function/dysfunction plays in the association between stress and neurodevelopmental outcomes in full-term and preterm infants. Although multiple limitations were found based on the lack of data on the influence of biological sex, and due to invasive sampling, and lack of longitudinal data, many genes and proteins associated with mitochondrial function/dysfunction were found to influence neurodevelopmental outcomes in the early life of infants.

Indexed as

Infant, PrematureMitochondriaNeurodevelopmental DisordersStress, PhysiologicalFemaleHumansInfantInfant, NewbornPregnancyInfantMitochondrial function/dysfunctionNeurodevelopmental outcomesStress

Identifiers

PMID35995037
PMCPMC9928905
OpenAlexW4292664281

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.