Evidence map›Paper›PMID 35994673›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

TPL2 kinase expression is regulated by the p38γ/p38δ-dependent association of aconitase-1 with

Alejandra Escós, José Martín-Gómez, Diego González-Romero, Ester Díaz-Mora, Rosario Francisco-Velilla, Cesar Santiago, José M Cuezva, Sonia Domínguez-Zorita, Encarnación Martínez-Salas, Nahum Sonenberg and 3 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. p38γ and p38δ MAP kinases in inflammation.Biochemical Society transactions · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 4 countries.

Alejandra EscósDepartment of Immunology and Oncology, Centro Nacional de Biotecnología-Consejo Superior de Investigaciones Científicas (CNB/CSIC) Campus Universidad Autónoma de Madrid (UAM), Madrid, 28049 Spain.
José Martín-GómezDepartment of Immunology and Oncology, Centro Nacional de Biotecnología-Consejo Superior de Investigaciones Científicas (CNB/CSIC) Campus Universidad Autónoma de Madrid (UAM), Madrid, 28049 Spain.ORCID 0000-0001-7656-6447
Diego González-RomeroDepartment of Immunology and Oncology, Centro Nacional de Biotecnología-Consejo Superior de Investigaciones Científicas (CNB/CSIC) Campus Universidad Autónoma de Madrid (UAM), Madrid, 28049 Spain.ORCID 0000-0002-0564-3326
Ester Díaz-MoraDepartment of Immunology and Oncology, Centro Nacional de Biotecnología-Consejo Superior de Investigaciones Científicas (CNB/CSIC) Campus Universidad Autónoma de Madrid (UAM), Madrid, 28049 Spain.ORCID 0000-0002-4233-0943
Rosario Francisco-VelillaDepartment of Genome Dynamics and Function, Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas-Universidad Autonoma de Madrid (CSIC-UAM), Madrid, 28049 Spain.ORCID 0000-0002-4328-8732
Cesar SantiagoDepartment of Macromolecular Structures, Centro Nacional de Biotecnología-Consejo Superior de Investigaciones Científicas (CNB/CSIC), Madrid, 28049 Spain.ORCID 0000-0002-5149-1722
José M CuezvaDepartamento de Biología Molecular, Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas-Universidad Autonoma de Madrid (CSIC-UAM), Universidad Autónoma de Madrid, Madrid, 28049 Spain.ORCID 0000-0003-1118-248X
Sonia Domínguez-ZoritaDepartamento de Biología Molecular, Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas-Universidad Autonoma de Madrid (CSIC-UAM), Universidad Autónoma de Madrid, Madrid, 28049 Spain.ORCID 0000-0001-5764-3531
Encarnación Martínez-SalasDepartment of Genome Dynamics and Function, Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas-Universidad Autonoma de Madrid (CSIC-UAM), Madrid, 28049 Spain.ORCID 0000-0002-8432-5587
Nahum SonenbergGoodman Cancer Research Centre, McGill University, Montréal, QC, H3A 1A3 Canada.ORCID 0000-0002-4707-8759
Juan José Sanz-EzquerroDepartment of Molecular and Cellular Biology, Centro Nacional de Biotecnología-Consejo Superior de Investigaciones Científicas (CNB/CSIC), Madrid, 28049 Spain.ORCID 0000-0002-9084-6354
Seyed Mehdi JafarnejadPatrick G. Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, BT9 7AE United Kingdom.ORCID 0000-0002-5129-7081
Ana CuendaDepartment of Immunology and Oncology, Centro Nacional de Biotecnología-Consejo Superior de Investigaciones Científicas (CNB/CSIC) Campus Universidad Autónoma de Madrid (UAM), Madrid, 28049 Spain.ORCID 0000-0002-9013-5077
Consejo Superior de Investigaciones Científicas · ESMcGill University Health Centre · CAQueen's University Belfast · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

p38γ and p38δ (p38γ/p38δ) regulate inflammation, in part by controlling tumor progression locus 2 (TPL2) expression in myeloid cells. Here, we demonstrate that TPL2 protein levels are dramatically reduced in p38γ/p38δ-deficient (p38γ/δ

Indexed as

Aconitate HydrataseMAP Kinase Kinase KinasesMitogen-Activated Protein Kinase 12Mitogen-Activated Protein Kinase 13Gene Expression RegulationImmunity, InnateRNA, MessengerAconitate HydrataseMAP Kinase Kinase KinasesMitogen-Activated Protein Kinase 12Mitogen-Activated Protein Kinase 13RNA, Messenger3′UTRACO1mRNA translationp38γ/p38δ-MAPKTPL2

Identifiers

PMID35994673
PMCPMC9436348
OpenAlexW4292701968

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.