ArticleProceedings of the National Academy of Sciences of the United States of America2022
Leisure-time sedentary behaviors are differentially associated with all-cause dementia regardless of engagement in physical activity.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 8 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 8 syntheses or guidelines pooled it, 76 citations in OpenAlex.
- Impact of Different Types of Sedentary Behaviour on Cognitive Function in Older Adults: A Systematic Review.Health promotion journal of Australia : official journal of Australian Association of Health Promotion Professionals · 2026Pooled it
- Individual sedentary activities and cognitive function in middle-aged and older adults: A systematic review.Journal of Alzheimer's disease : JAD · 2026Pooled it
- Acute effects of physical activity breaking up sedentary behavior on cognitive function, biological mechanisms, and practical recommendations: a systematic review.Frontiers in psychology · 2026Pooled it
- A meta-analysis of technology use and cognitive aging.Nature human behaviour · 2025Pooled it
- Association between sedentary behavior and dementia: a systematic review and meta-analysis of cohort studies.BMC psychiatry · 2025Pooled it
- Shared reading interventions to promote psychosocial well-being in older adults: a systematic review.Health promotion international · 2025Pooled it
- Pooled it
- Causal Association Between Sedentary Behaviors and Health Outcomes: A Systematic Review and Meta-Analysis of Mendelian Randomization Studies.Sports medicine (Auckland, N.Z.) · 2024Pooled it
- Inactivity is isolation: insights from a sedentary time intervention in assisted living.BMC geriatrics · 2025Trial
- Effects of intermittent exercise during prolonged sitting on executive function, cerebrovascular, and psychological response: a randomized crossover trial.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Trial
- Evaluating Physical Frailty as a Marker of Cognitive Health in Older Adults without Dementia.Journal of geriatric psychiatry and neurology · 2026Article
- Longitudinal transitions in sedentary behavior and physical activity in relation to all-cause and cause-specific mortality among postmenopausal women.GeroScience · 2026Observational
- Associations of distinct sedentary behaviors with cortical, subcortical, and white matter hyperintensity volumes: Evidence from the ARIC study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Television and computer use and dementia risk in older adults with limited leisure or social activities: A prospective cohort study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Beyond FITT: addressing density in understanding the dose-response relationships of physical activity with health-an example based on brain health.European journal of applied physiology · 2025Review
- Nonlinear Associations of Accelerometer-Based Sedentary Time With Cognitive Functions in the UK Biobank.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- How Do Occupational Sedentary Behavior and Occupational Cognitive Complexity Relate to Cognitive Function? A Cross-Sectional Study.Health science reports · 2025Article
- Association of changes in overall and specific leisure activities with long-term all-cause mortality in older adults: a nationwide cohort study.Journal of global health · 2025Article
- Observational and genetic evidence highlight the association of modifiable risk factors with the incidence and severity of neuroimmunological disorders.Brain, behavior, & immunity - health · 2025Article
- Current and historic patterns of chronic disease burden are associated with physical activity and sedentary behavior in older adults: an observational study.BMC public health · 2025Observational
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Sedentary behavior (SB) is associated with cardiometabolic disease and mortality, but its association with dementia is currently unclear. This study investigates whether SB is associated with incident dementia regardless of engagement in physical activity (PA). A total of 146,651 participants from the UK Biobank who were 60 years or older and did not have a diagnosis of dementia (mean [SD] age: 64.59 [2.84] years) were included. Self-reported leisure-time SBs were divided into two domains: time spent watching television (TV) or time spent using a computer. A total of 3,507 individuals were diagnosed with all-cause dementia over a mean follow-up of 11.87 (±1.17) years. In models adjusted for a wide range of covariates, including time spent in PA, time spent watching TV was associated with increased risk of incident dementia (HR [95% CI] = 1.24 [1.15 to 1.32]) and time spent using a computer was associated with decreased risk of incident dementia (HR [95% CI] = 0.85 [0.81 to 0.90]). In joint associations with PA, TV time and computer time remained significantly associated with dementia risk at all PA levels. Reducing time spent in cognitively passive SB (i.e., TV time) and increasing time spent in cognitively active SB (i.e., computer time) may be effective behavioral modification targets for reducing risk of dementia regardless of engagement in PA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.