Evidence map›Paper›PMID 35994659›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Exploiting breakdown in nonhost effector-target interactions to boost host disease resistance.

Hazel McLellan, Sarah E Harvey, Jens Steinbrenner, Miles R Armstrong, Qin He, Rachel Clewes, Leighton Pritchard, Wei Wang, Shumei Wang, Thomas Nussbaumer and 13 more

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
8.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 40 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Deciphering the Molecular Interplay Between RXLR-EncodedInternational journal of molecular sciences · 2025
    Review
  6. Review
  7. Article
  8. Article
  9. Serotype Distribution and Antimicrobial Resistance ofAntibiotics (Basel, Switzerland) · 2024
    Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 4 institutions in 4 countries.

Hazel McLellanDivision of Plant Sciences, School of Life Science, University of Dundee (at James Hutton Institute), Invergowrie, Dundee DD2 5DA, United Kingdom.ORCID 0000-0003-4490-7053
Sarah E HarveyCentre for Novel Agricultural Products, Department of Biology, University of York, York YO10 5DD, United Kingdom.ORCID 0000-0001-8155-7529
Jens SteinbrennerLife Sciences, University of Warwick, Coventry CV4 7AL, United Kingdom.ORCID 0000-0003-1008-2268
Miles R ArmstrongDivision of Plant Sciences, School of Life Science, University of Dundee (at James Hutton Institute), Invergowrie, Dundee DD2 5DA, United Kingdom.
Qin HeDivision of Plant Sciences, School of Life Science, University of Dundee (at James Hutton Institute), Invergowrie, Dundee DD2 5DA, United Kingdom.
Rachel ClewesLife Sciences, University of Warwick, Coventry CV4 7AL, United Kingdom.
Leighton PritchardInformation and Computational Sciences, James Hutton Institute, Invergowrie, Dundee DD2 5DA, United Kingdom.ORCID 0000-0002-8392-2822
Wei WangDivision of Plant Sciences, School of Life Science, University of Dundee (at James Hutton Institute), Invergowrie, Dundee DD2 5DA, United Kingdom.
Shumei WangDivision of Plant Sciences, School of Life Science, University of Dundee (at James Hutton Institute), Invergowrie, Dundee DD2 5DA, United Kingdom.ORCID 0000-0002-1822-6847
Thomas NussbaumerInstitute of Network Biology, Helmholtz Zentrum Munchen, German Research Centre for Environmental Health, Munich, Germany.
Bushra DohaiInstitute of Network Biology, Helmholtz Zentrum Munchen, German Research Centre for Environmental Health, Munich, Germany.ORCID 0000-0001-8179-8883
Qingquan LuoJustus Liebig Universität Giessen, JLU Institute of Phytopathology, Giessen, Hesse, Germany.ORCID 0000-0003-4371-273X
Priyanka KumariJustus Liebig Universität Giessen, JLU Institute of Phytopathology, Giessen, Hesse, Germany.
Hui DuanSimplot Plant Sciences, J. R. Simplot Company, Boise, ID 83707.ORCID 0000-0002-0142-3262
Ana RobertsLife Sciences, University of Warwick, Coventry CV4 7AL, United Kingdom.
Petra C BoevinkDepartment of Cell and Molecular Sciences, James Hutton Institute, Invergowrie, Dundee DD2 5DA, United Kingdom.ORCID 0000-0002-7021-9097
Christina NeumannJustus Liebig Universität Giessen, JLU Institute of Phytopathology, Giessen, Hesse, Germany.
Nicolas ChampouretSimplot Plant Sciences, J. R. Simplot Company, Boise, ID 83707.ORCID 0000-0001-8956-7561
Ingo HeinDivision of Plant Sciences, School of Life Science, University of Dundee (at James Hutton Institute), Invergowrie, Dundee DD2 5DA, United Kingdom.
Pascal Falter-BraunInstitute of Network Biology, Helmholtz Zentrum Munchen, German Research Centre for Environmental Health, Munich, Germany.ORCID 0000-0003-2012-6746
Jim BeynonLife Sciences, University of Warwick, Coventry CV4 7AL, United Kingdom.ORCID 0000-0002-1855-3215
Katherine DenbyCentre for Novel Agricultural Products, Department of Biology, University of York, York YO10 5DD, United Kingdom.ORCID 0000-0002-7857-6814
Paul R J BirchDivision of Plant Sciences, School of Life Science, University of Dundee (at James Hutton Institute), Invergowrie, Dundee DD2 5DA, United Kingdom.
University of Strathclyde · GBJames Hutton Institute · GBSimplot (United States) · USUniversity of California, Riverside · US

Funding

Biotechnology and Biological Sciences Research Council BB/S015663/1UKRI | Biotechnology and Biological Sciences Research Council (BBSRC) BB/G015244/1UKRI | Biotechnology and Biological Sciences Research Council (BBSRC) BB/K018183/1UKRI | Biotechnology and Biological Sciences Research Council (BBSRC) BB/K018612/1UKRI | Biotechnology and Biological Sciences Research Council (BBSRC) BB/K018612/2UKRI | Biotechnology and Biological Sciences Research Council (BBSRC) BB/N009967/1UKRI | Biotechnology and Biological Sciences Research Council (BBSRC) BB/P020569/1
6 · The paper itself

Abstract

Plants are resistant to most microbial species due to nonhost resistance (NHR), providing broad-spectrum and durable immunity. However, the molecular components contributing to NHR are poorly characterised. We address the question of whether failure of pathogen effectors to manipulate nonhost plants plays a critical role in NHR. RxLR (Arg-any amino acid-Leu-Arg) effectors from two oomycete pathogens,

Indexed as

ArabidopsisDisease ResistanceHost SpecificityNicotianaPlant DiseasesPlant ProteinsOomycetesPhytophthora infestansSolanum tuberosumTwo-Hybrid System TechniquesPlant Proteinseffector-triggered susceptibilityhost rangeoomyceteplant immunityplant–microbe interactions

Identifiers

PMID35994659
PMCPMC9436328
OpenAlexW4292651863

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.