Evidence map›Paper›PMID 35994647›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Malaria parasite evades mosquito immunity by glutaminyl cyclase-mediated posttranslational protein modification.

Surendra Kumar Kolli, Alvaro Molina-Cruz, Tamasa Araki, Fiona J A Geurten, Jai Ramesar, Severine Chevalley-Maurel, Hans J Kroeze, Sascha Bezemer, Clarize de Korne, Roxanne Withers and 13 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. The Plasmodium circumsporozoite protein.Trends in parasitology · 2024
    Review
  7. Review
  8. Late sporogonic stages ofbioRxiv : the preprint server for biology · 2024
    Article
  9. Article
  10. Late sporogonic stages ofFrontiers in cellular and infection microbiology · 2024
    Article
  11. Review
  12. Host-parasite interactions duringFrontiers in immunology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 5 institutions in 4 countries.

Surendra Kumar KolliMalaria Research Group, Department of Parasitology, Leiden University Medical Center, Leiden, 2333 ZA, The Netherlands.ORCID 0000-0001-6125-0036
Alvaro Molina-CruzLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, NIH, Rockville, MD, 20852.ORCID 0000-0001-5137-4836
Tamasa ArakiDepartment of Parasitology, National Institute of Infectious Diseases, Shinjuku-ku, Tokyo 162-8640, Japan.
Fiona J A GeurtenMalaria Research Group, Department of Parasitology, Leiden University Medical Center, Leiden, 2333 ZA, The Netherlands.
Jai RamesarMalaria Research Group, Department of Parasitology, Leiden University Medical Center, Leiden, 2333 ZA, The Netherlands.
Severine Chevalley-MaurelMalaria Research Group, Department of Parasitology, Leiden University Medical Center, Leiden, 2333 ZA, The Netherlands.
Hans J KroezeMalaria Research Group, Department of Parasitology, Leiden University Medical Center, Leiden, 2333 ZA, The Netherlands.
Sascha BezemerMalaria Research Group, Department of Parasitology, Leiden University Medical Center, Leiden, 2333 ZA, The Netherlands.
Clarize de KorneMalaria Research Group, Department of Parasitology, Leiden University Medical Center, Leiden, 2333 ZA, The Netherlands.
Roxanne WithersLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, NIH, Rockville, MD, 20852.
Nadia RaytselisLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, NIH, Rockville, MD, 20852.
Angela F El HebieshyOncode Institute, Leiden University Medical Center, Leiden, 2333 ZC, The Netherlands.
Robbert Q KimOncode Institute, Leiden University Medical Center, Leiden, 2333 ZC, The Netherlands.
Matthew A ChildDepartment of Life Sciences, Imperial College London, London, SW7 2AZ, United Kingdom.ORCID 0000-0002-1565-5638
Soichiro KakutaLaboratory of Morphology and Image Analysis, Research Support Center, Juntendo University Graduate School of Medicine, Bunkyo, Tokyo 113-8421, Japan.
Hajime HisaedaDepartment of Parasitology, National Institute of Infectious Diseases, Shinjuku-ku, Tokyo 162-8640, Japan.
Hirotaka KobayashiDepartment of Pathology, National Institute of Infectious Diseases, Shinjukuku, Tokyo 162-8640, Japan.
Takeshi AnnouraDepartment of Parasitology, National Institute of Infectious Diseases, Shinjuku-ku, Tokyo 162-8640, Japan.
Paul J HensbergenCenter for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, 2333 ZA, The Netherlands.ORCID 0000-0002-3193-5445
Blandine M Franke-FayardMalaria Research Group, Department of Parasitology, Leiden University Medical Center, Leiden, 2333 ZA, The Netherlands.
Carolina Barillas-MuryLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, NIH, Rockville, MD, 20852.ORCID 0000-0002-4039-6199
Ferenc A ScheerenDepartment of Dermatology, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands.
Chris J JanseMalaria Research Group, Department of Parasitology, Leiden University Medical Center, Leiden, 2333 ZA, The Netherlands.ORCID 0000-0002-6410-6205
Leiden University Medical Center · NLNational Institute of Allergy and Infectious Diseases · USNational Institute of Infectious Diseases · JPImperial College London · GBJuntendo University · JP

Funding

Mosquito Midgut Immune Responses &Malaria TransmissionZ01AI000947 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI BARILLAS-MURY, CAROLINA · 2004 to 2008
$1.8M
Intramural NIH HHS Z01 AI000947
6 · The paper itself

Abstract

Glutaminyl cyclase (QC) modifies N-terminal glutamine or glutamic acid residues of target proteins into cyclic pyroglutamic acid (pGlu). Here, we report the biochemical and functional analysis of

Indexed as

AminoacyltransferasesCulicidaeMalariaProtein Processing, Post-TranslationalSporozoitesAnimalsGlutamic AcidGlutamineHumansPlasmodium bergheiProtozoan ProteinsAminoacyltransferasesGlutamic AcidGlutamineglutaminyl-peptide cyclotransferaseProtozoan Proteinsglutaminyl cyclaseimmune evasionmelanizationpyroglutamic acidsporozoite

Identifiers

PMID35994647
PMCPMC9436314
OpenAlexW4292651769

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.