Evidence map›Paper›PMID 35994521›Full record

ArticleCurrent protocols2022

A Mouse Model of Celiac Disease.

Valérie Abadie, Chaitan Khosla, Bana Jabri

Open access · bronzeAbstract read
In one paragraph

Article in Current protocols, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Gastrointestinal tract, its pathophysiology andWorld journal of gastroenterology · 2025
    Review
  6. Review
  7. Review
  8. Cellular and molecular basis of proximal small intestine disorders.Nature reviews. Gastroenterology & hepatology · 2024
    Review
  9. Review
  10. A Mouse Model of Celiac Disease.Current protocols · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Valérie AbadieDepartment of Medicine, University of Chicago, Chicago, Illinois.
Chaitan KhoslaDepartment of Chemistry, Stanford University, Stanford, California.
Bana JabriDepartment of Medicine, University of Chicago, Chicago, Illinois.
University of Illinois Chicago · USStanford Medicine · US

Funding

ULTRASTRUCTURE AND CYTOMORPHOLOGY COREP30DK042086 · NIDDK · UNIVERSITY OF CHICAGO · PI CHANG, EUGENE B · 1990 to 2025
$29.8M
Role of Transglutaminase 2 in Celiac SprueR01DK063158 · NIDDK · STANFORD UNIVERSITY · PI CHAITAN KHOSLA · 2003 to 2026
$11.2M
Innate and adaptive immunity in celiac diseaseR01DK067180 · NIDDK · UNIVERSITY OF CHICAGO · PI JABRI, BANA · 2005 to 2024
$8.5M
B cell-T cell crosstalk in celiac diseaseR01DK128352 · NIDDK · UNIVERSITY OF CHICAGO · PI ABADIE, VALERIE · 2021 to 2025
$2.1M
Localizing Pathogenically Relevant Transglutaminase 2 in Celiac DiseaseR01DK126487 · NIDDK · STANFORD UNIVERSITY · PI JABRI, BANA, KHOSLA, CHAITAN · 2021 to 2025
$1.8M
NIDDK NIH HHS P30 DK042086NIDDK NIH HHS R01 DK063158NIDDK NIH HHS R01 DK067180NIDDK NIH HHS R01 DK126487NIDDK NIH HHS R01 DK128352NIH HHS R01 DK063158NIH HHS R01 DK067180NIH HHS R01 DK126487NIH HHS R01 DK128352
6 · The paper itself

Abstract

The design and use of mouse models that reproduce key features of human diseases are critical to advance our understanding of the pathogenesis of autoimmune diseases and to test new therapeutic strategies. Celiac disease is a unique organ-specific autoimmune-like disorder occurring in genetically susceptible individuals carrying HLA-DQ2 or HLA-DQ8 molecules who consume gluten. The key histological characteristic of the disease in humans is the destruction of the lining of the small intestine, a feature that has been difficult to reproduce in immunocompetent animal models. This unit describes the DQ8-D

Indexed as

Celiac DiseaseAnimalsAtrophyDisease Models, AnimalGliadinGlutensHumansMiceMice, TransgenicGliadinGlutensceliac diseaseintraepithelial lymphocytesmouse modeltransglutaminase 2villous atrophy

Identifiers

PMID35994521
PMCPMC10203737
OpenAlexW4292635820

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.