ArticleEvolution; international journal of organic evolution2022
Genetic architecture of repeated phenotypic divergence in Littorina saxatilis ecotype evolution.
Article in Evolution; international journal of organic evolution, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 33 citations in OpenAlex.
- Maintenance of phenotypic divergence in two sympatric monkeyflowers with weak reproductive isolation.bioRxiv : the preprint server for biology · 2026Article
- Shifting Balancing Selection Underlies an Inversion Cline in Eurasian Blackcap.Ecology and evolution · 2026Article
- Article
- Putting Structural Variants Into Practice: The Role of Chromosomal Inversions in the Management of Marine Environments.Molecular ecology · 2025Review
- Sex Differentiation and Long-Distance Gene Flow in the Elusive Antarctic FishEcology and evolution · 2025Article
- Selection Over Small and Large Spatial Scales in the Face of High Gene Flow.Molecular ecology · 2025Article
- Rapid Parallel Adaptation in Distinct Invasions of Ambrosia Artemisiifolia Is Driven by Large-Effect Structural Variants.Molecular biology and evolution · 2025Article
- Genetic Determination of a Cryptic Species in theEcology and evolution · 2024Article
- Chromosomal inversion polymorphisms are widespread across the species ranges of rough periwinkles (Littorina saxatilis and L. arcana).Molecular ecology · 2024Article
- Coupling of twelve putative chromosomal inversions maintains a strong barrier to gene flow between snail ecotypes.Evolution letters · 2024Article
- Coupling of Barriers to Gene Exchange: Causes and Consequences.Cold Spring Harbor perspectives in biology · 2024Review
- Chromosome-scale Genome Assembly of the Rough Periwinkle Littorina saxatilis.Genome biology and evolution · 2024Article
- Inversion invasions: when the genetic basis of local adaptation is concentrated within inversions in the face of gene flow.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
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Authors and funding
5 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chromosomal inversions have been shown to play a major role in a local adaptation by suppressing recombination between alternative arrangements and maintaining beneficial allele combinations. However, so far, their importance relative to the remaining genome remains largely unknown. Understanding the genetic architecture of adaptation requires better estimates of how loci of different effect sizes contribute to phenotypic variation. Here, we used three Swedish islands where the marine snail Littorina saxatilis has repeatedly evolved into two distinct ecotypes along a habitat transition. We estimated the contribution of inversion polymorphisms to phenotypic divergence while controlling for polygenic effects in the remaining genome using a quantitative genetics framework. We confirmed the importance of inversions but showed that contributions of loci outside inversions are of similar magnitude, with variable proportions dependent on the trait and the population. Some inversions showed consistent effects across all sites, whereas others exhibited site-specific effects, indicating that the genomic basis for replicated phenotypic divergence is only partly shared. The contributions of sexual dimorphism as well as environmental factors to phenotypic variation were significant but minor compared to inversions and polygenic background. Overall, this integrated approach provides insight into the multiple mechanisms contributing to parallel phenotypic divergence.
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