ArticleBiological trace element research2023
Effects of Lead and Cadmium Combined Heavy Metals on Liver Function and Lipid Metabolism in Mice.
Article in Biological trace element research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 45 citations in OpenAlex.
- Embryonic lead (Pb) contact impairs lipid, oxidative, and behavioral markers in zebrafish across multiple generations.Environmental research · 2026Article
- Low-level Blood Multiple Metals Exposure from Informal Jewelry Welding Alters Metabolomic and Lipidomic Profiles in Brazilian Women.Biological trace element research · 2026Article
- Joint Associations of Prenatal Per- and Polyfluoroalkyl Substances and Metal Mixtures with Adiposity in Childhood and Adolescence.Environmental science & technology · 2026Article
- Ameliorative Potential of a Lactobacillus Based Probiotic Consortium Against Hepatotoxicity Induced by Combinatorial Exposure to Multiple Heavy Metals.Probiotics and antimicrobial proteins · 2026Article
- Honokiol antagonizes cadmium-induced ultrastructural nuclear variation and mitochondrial dysfunction of hepatocytes through targeting Bax protein.Poultry science · 2026Article
- Lead and cadmium levels in blood among painters and battery workers: A case control study.Bioinformation · 2026Article
- Effect of co-exposure to multiple metals (Pb, Cd, Cr, Hg, Fe, Mn and Ni) and metalloid (As) on liver function in Swiss albino mice.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025Article
- Article
- Heavy Metal Contamination: Sources, Health Impacts, and Sustainable Mitigation Strategies with Insights from Nigerian Case Studies.F1000Research · 2025Review
- Risk assessment of heavy metal toxicity induced by platinum accumulation in tumor patients.PeerJ · 2025Article
- Guardians of the Gut: Harnessing the Power of Probiotic Microbiota and Their Exopolysaccharides to Mitigate Heavy Metal Toxicity in Human for Better Health.Probiotics and antimicrobial proteins · 2024Review
- Lead poisoning as a differential diagnosis in pediatric patients with chronic abdominal pain: a case-control study in Tehran-Iran.BMC gastroenterology · 2024Article
- Cadmium toxicity on endoplasmic reticulum functioning.International journal of biochemistry and molecular biology · 2024Review
- The single and mixed impacts of cadmium, cobalt, lead, and PAHs on systemic immunity inflammation index in male and female.Frontiers in public health · 2024Article
- Docosahexaenoic Acid Promotes Cd Excretion by Restoring the Abundance ofMolecules (Basel, Switzerland) · 2023Article
- Sex, Nutrition, and NAFLD: Relevance of Environmental Pollution.Nutrients · 2023Review
Corrections and comments
- Erratum issued
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Although a large number of studies have been conducted on lead (Pb) and cadmium (Cd) exposure individually, information regarding the toxicity of combined Pb and Cd exposure is relatively limited. The present study aims to investigate the toxicity of Pb-Cd combination exposure and the corresponding mechanism. A heavy metal exposure model was established in mice by subcutaneous intragastric administration of Pb-Cd (50:1) for 35 days. Body weight, diet, hair state, mental state, liver index, haematological index, biochemical indicators and pathological section analysis were used to comprehensively evaluate toxicity. Then, classical oxidative stress indexes and lipidomics techniques were used to explore the potential mechanism. The results showed that Pb-Cd caused the mice to have low appetite, poor spirit, significantly reduced activity, slow weight gain and irritated or drying hair. Pb-Cd also caused liver enlargement, significantly increased aspartate aminotransferase (AST) and alanine aminotransferase (ALT) enzyme activities, and resulted in pathological changes to the liver. Prolonged Pb-Cd exposure led to significantly increased thrombocyte haematocrit (PCT), white blood cell (WBC), platelet (PLT) and monocyte (MON) counts and decreased red blood cell (RBC), haemoglobin (HGB), haematocrit (HCT) and lymphocyte (LYM) counts. Pb-Cd increased oxidative stress by increasing the activity of superoxide dismutase (SOD) and lactate dehydrogenase (LDH) and the content of malondialdehyde (MDA). Finally, Pb-Cd triggered lipid metabolism disorders by regulating linoleic acid, sphingolipid and glycerolipid metabolism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.