Evidence map›Paper›PMID 35994012›Full record

ArticleCannabis and cannabinoid research2023

Therapeutic Effects of Non-Euphorigenic Cannabis Extracts in Osteoarthritis.

Vengadeshprabhu Karuppagounder, Juliet Chung, Ahmed Abdeen, Amy Thompson, Andreas Bouboukas, William J Pinamont, Natalie K Yoshioka, Diana E Sepulveda, Wesley M Raup-Konsavage, Nicholas M Graziane and 3 more

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Cannabis and cannabinoid research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07638189 (Pilot Study Using Topical Cannabidiol), which is not on this map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07638189 phase2not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Pilot Study Using Topical Cannabidiol (CBD) to Manage Osteoarthritic Knee Pain

TypeinterventionalSponsorUniversity of TennesseeRan2026 to 2028Enrolled30ConditionsOsteoarthitisArmsCannabidiol (CBD), Castor Oil (Placebo)
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Phytocannabinoids and bone health.Current osteoporosis reports · 2026
    Review
  4. Review
  5. Review
  6. Cannabidiol and Cannabigerol, Nonpsychotropic Cannabinoids, as Analgesics that Effectively Manage Bone Fracture Pain and Promote Healing in Mice.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2023
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Vengadeshprabhu KaruppagounderCenter for Orthopedic Research and Translational Science (CORTS), Penn State College of Medicine, Hershey, Pennsylvania, USA.
Juliet ChungCenter for Orthopedic Research and Translational Science (CORTS), Penn State College of Medicine, Hershey, Pennsylvania, USA.
Ahmed AbdeenCenter for Orthopedic Research and Translational Science (CORTS), Penn State College of Medicine, Hershey, Pennsylvania, USA.
Amy ThompsonCenter for Orthopedic Research and Translational Science (CORTS), Penn State College of Medicine, Hershey, Pennsylvania, USA.
Andreas BouboukasCenter for Orthopedic Research and Translational Science (CORTS), Penn State College of Medicine, Hershey, Pennsylvania, USA.
William J PinamontCenter for Orthopedic Research and Translational Science (CORTS), Penn State College of Medicine, Hershey, Pennsylvania, USA.ORCID 0000-0002-9142-8031
Natalie K YoshiokaCenter for Orthopedic Research and Translational Science (CORTS), Penn State College of Medicine, Hershey, Pennsylvania, USA.
Diana E SepulvedaPharmacology, Penn State College of Medicine, Hershey, Pennsylvania, USA.
Wesley M Raup-KonsavagePharmacology, Penn State College of Medicine, Hershey, Pennsylvania, USA.
Nicholas M GrazianePharmacology, Penn State College of Medicine, Hershey, Pennsylvania, USA.ORCID 0000-0002-7055-7029
Kent E VranaPharmacology, Penn State College of Medicine, Hershey, Pennsylvania, USA.
Reyad A ElbarbaryCenter for Orthopedic Research and Translational Science (CORTS), Penn State College of Medicine, Hershey, Pennsylvania, USA.
Fadia KamalCenter for Orthopedic Research and Translational Science (CORTS), Penn State College of Medicine, Hershey, Pennsylvania, USA.ORCID 0000-0003-2408-4061
Penn State Milton S. Hershey Medical Center · US

Funding

Regulation of microRNA homeostasis: Implications in bone fracture healingR01DK121327 · NIDDK · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI ELBARBARY, REYAD A · 2019 to 2023
$2.0M
Therapeutic targeting of GPCR Gbetagamma-GRK2 in osteoarthritisR01AR071968 · NIAMS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KAMAL, FADIA ALI · 2019 to 2023
$1.7M
NIAMS NIH HHS R01 AR071968NIDDK NIH HHS R01 DK121327
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

CannabisOsteoarthritisAnimalsDisease Models, AnimalHumansInflammationMaleMiceMice, Inbred C57BLPaincannabinoidsDMOADosteoarthritispaintherapeutics

Identifiers

PMID35994012
PMCPMC10714119
OpenAlexW4292634364

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.