ArticleAging & mental health2022
The role of frailty in the association between depression and fall risk among older adults.
Article in Aging & mental health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- Daily activity patterns from wearable accelerometry predict physical frailty and concern about falling.NPJ digital medicine · 2026Article
- Association Between Depressive Symptoms and Physiological Risk Factors for Falls.Journal of aging research · 2026Article
- The Impact of Falls on Depressive Symptoms in Middle-Aged and Older Chinese Adults: Mediating Effects of Pain.Psychology research and behavior management · 2026Article
- The relationship between socio-economic and demographic factors, quality of life and depression in older women in institutional care in Poland - a cross-sectional study.BMC geriatrics · 2025Article
- Association of health promotion behaviors with frailty in Chinese middle-aged and older adults: a cross-sectional study.BMC geriatrics · 2025Article
- Global, regional, and national burden of geriatric depressive disorders in people aged 60 years and older: an analysis of the Global Burden of Disease Study 2021.Annals of general psychiatry · 2025Article
- Utilizing machine learning to identify fall predictors in India's aging population: findings from the LASI.BMC geriatrics · 2025Article
- Mindfulness, Depression, and Fall Risk in Low-Income Older Adults.Research in health and medicine · 2025Article
- The curvilinear associations between Life's Crucial 9 and frailty: cross-sectional study of NHANES 2003 - 2023.Frontiers in aging · 2025Article
- Clinical and Psychological Factors Associated with Frailty in Patients with Heart Failure.Journal of clinical medicine · 2024Article
- [Prevention of depression in old age: individual and societal relevance].Zeitschrift fur Gerontologie und Geriatrie · 2024Article
- The mediating effect of life satisfaction between daily living abilities and depressive symptoms in the Chinese older people: evidence from CHARLS 2020.Frontiers in public health · 2024Article
- Low physical activity and depression are the prominent predictive factors for falling in older adults: the Birjand Longitudinal Aging Study (BLAS).BMC geriatrics · 2023Article
- Variability and symmetry of gait kinematics under dual-task performance of older patients with depression.Aging clinical and experimental research · 2023Article
- The key role of depression and supramarginal gyrus in frailty: a cross-sectional study.Frontiers in aging neuroscience · 2023Article
- Association of Frailty Status with Risk of Fall among Hospitalized Elderly Patients: A Cross-Sectional Study in an Acute Geriatric Unit.Medicines (Basel, Switzerland) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesAlthough there is a recognized association between depression and greater fall risk among older adults, the mechanisms explaining this association are unclear. This study evaluated the role of frailty, a common geriatric syndrome, in determining greater risk of falls among older adults with depression.
methodWe used longitudinal data from three biennial waves of the Health and Retirement Study (HRS; 2010-2014). The sample included community-dwelling survey respondents age ≥ 65 who participated in objective physiological measures. Major Depression (MD) was measured using Composite International Diagnostic Interview for depression short form. Frailty was measured using criteria outlined in the frailty phenotype model. Causal mediation analysis was used to differentiate the direct effect of depression and indirect effect mediated by frailty on falls, fall injuries, and multiple falls.
resultsMajor depression was associated with significantly greater odds of experiencing a fall (OR: 1.91; 95% CI: 1.31, 2.77), fall injury (OR: 1.86; 95% CI: 1.17, 2.95), and multiple falls (OR: 2.26; 95% CI: 1.52, 3.37) over a two-year period. Frailty was a significant mediator of the effects of depression on falls and multiple falls, accounting for approximately 18.9% and 21.3% of the total effects, respectively. We found no evidence of depression-frailty interaction. Sensitivity analyses showed that results were robust to unmeasured confounding and alternative operationalizations of depression.
conclusionFrailty explains a significant proportion of increased likelihood of falls among older adults with depression. Treatment and management of frailty symptoms may be an important components of fall prevention among older adults with depression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.