ArticlemBio2022
Collaboration between Antagonistic Cell Type Regulators Governs Natural Variation in the Candida albicans Biofilm and Hyphal Gene Expression Network.
Article in mBio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 30 citations in OpenAlex.
- Two Ume6 target gene classes in the biofilm regulatory network ofbioRxiv : the preprint server for biology · 2026Article
- Negative control of Candida albicans biofilm formation by combined action of white-opaque regulator Wor2 and biofilm regulator Bcr1.G3 (Bethesda, Md.) · 2026Article
- Article
- An emergent biofilm program from inactivation of Candida albicans master regulators Efg1 and Ndt80.PLoS pathogens · 2026Article
- Impact ofmSphere · 2026Article
- Ume6 protein complexes connect morphogenesis, adherence and hypoxic genes to shape Candida albicans biofilm architecture.Nature microbiology · 2025Article
- Transcriptional control ofmBio · 2025Article
- Article
- Strain variation inmSphere · 2024Article
- Alternative sulphur metabolism in the fungal pathogen Candida parapsilosis.Nature communications · 2024Article
- Gain- and loss-of-function alleles within signaling pathways lead to phenotypic diversity among individuals.iScience · 2024Article
- A Brg1-Rme1 circuit inmBio · 2024Article
- Candida albicans natural diversity: a resource to dissect fungal commensalism and pathogenesis.Current opinion in microbiology · 2024Review
- Strain variation in themSphere · 2024Article
- Regulatory features of Candida albicans hemin-induced filamentation.G3 (Bethesda, Md.) · 2024Article
- Biofilm-associated metabolism via ERG251 in Candida albicans.PLoS pathogens · 2024Article
- The role of themSphere · 2024Article
- Candida albicans and Antifungal Peptides.Infectious diseases and therapy · 2023Article
- Strain variation in gene expression impact of hyphal cyclin Hgc1 in Candida albicans.G3 (Bethesda, Md.) · 2023Article
- Candida albicans stimulates formation of a multi-receptor complex that mediates epithelial cell invasion during oropharyngeal infection.PLoS pathogens · 2023Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
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Abstract
Candida albicans is among the most significant human fungal pathogens. However, the vast majority of C. albicans studies have focused on a single clinical isolate and its marked derivatives. We investigated natural variation among clinical C. albicans isolates in gene regulatory control of biofilm formation, a process crucial to virulence. The transcription factor Efg1 is required for biofilm-associated gene expression and biofilm formation. Previously, we found extensive variation in Efg1-responsive gene expression among 5 diverse clinical isolates. However, chromatin immunoprecipitation sequencing analysis showed that Efg1 binding to genomic loci was uniform among the isolates. Functional dissection of strain differences identified three transcription factors, Brg1, Tec1, and Wor1, for which small changes in expression levels reshaped the Efg1 regulatory network. Brg1 and Tec1 are known biofilm activators, and their role in Efg1 network variation may be expected. However, Wor1 is a known repressor of
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Registered trials
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