ArticlemSystems2022
Epidemiology of Plasmid Lineages Mediating the Spread of Extended-Spectrum Beta-Lactamases among Clinical Escherichia coli.
Article in mSystems, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 29 citations in OpenAlex.
- How social is social resistance?Essays in biochemistry · 2026Review
- Tracking Extended-Spectrum β-Lactamase-ProducingAntibiotics (Basel, Switzerland) · 2026Article
- Epidemiology and Molecular Profiles of ESBL-ProducingMicroorganisms · 2026Article
- Community-associated quinolone-resistant and extended-spectrum beta-lactamase-producingmSystems · 2026Article
- Ecological context structures duplication and mobilization of antibiotic and metal resistance genes in bacteria.bioRxiv : the preprint server for biology · 2026Article
- Genome-wide co-occurrence patterns link mobile genetic elements, antimicrobial resistance and defense systems in Pseudomonas aeruginosa.BMC genomics · 2026Article
- Genomic epidemiology reveals statewide dispersal of clinical Shiga toxin-producingMicrobiology spectrum · 2026Article
- Exploration of the genomic diversity of third-generation cephalosporin-resistantMicrobial genomics · 2026Article
- Challenges and considerations for whole-genome-based antimicrobial resistance plasmid investigations.Antimicrobial agents and chemotherapy · 2025Review
- ACCIO: An Assembly-Based Tool Enabling Plasmid Detection.medRxiv : the preprint server for health sciences · 2025Article
- Plasmid-driven strategies for clone success in Escherichia coli.Nature communications · 2025Article
- Genomic insights into the plasmidome of non-tuberculous mycobacteria.Genome medicine · 2025Article
- Characterization of antibiotic determinants and heavy metal resistance genes inMicrobial genomics · 2025Article
- Commensal-pathogen dynamics structure disease outcomes during Clostridioides difficile colonization.Cell host & microbe · 2025Article
- Integration sites ofFrontiers in microbiology · 2025Article
- Characterization of novel sequence type 12531 and O8:H7 serotype carbapenem-resistantAntimicrobial agents and chemotherapy · 2024Article
- Comparison of CTX-M encoding plasmids present during the early phase of the ESBL pandemic in western Sweden.Scientific reports · 2024Article
- Genomic Epidemiology of C2/H30Rx and C1-M27 Subclades ofAntibiotics (Basel, Switzerland) · 2024Article
- Antibiotic perturbations to the gut microbiome.Nature reviews. Microbiology · 2023Review
- Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
The prevalence of extended-spectrum beta-lactamases (ESBLs) among clinical isolates of Escherichia coli has been increasing, with this spread driven by ESBL-encoding plasmids. However, the epidemiology of ESBL-disseminating plasmids remains understudied, obscuring the roles of individual plasmid lineages in ESBL spread. To address this, we performed an in-depth genomic investigation of 149 clinical ESBL-like E. coli isolates from a tertiary care hospital. We obtained high-quality assemblies for 446 plasmids, revealing an extensive map of plasmid sharing that crosses time, space, and bacterial sequence type boundaries. Through a sequence-based network, we identified specific plasmid lineages that are responsible for the dissemination of major ESBLs. Notably, we demonstrate that IncF plasmids separate into 2 distinct lineages that are enriched for different ESBLs and occupy distinct host ranges. Our work provides a detailed picture of plasmid-mediated spread of ESBLs, demonstrating the extensive sequence diversity within identified lineages, while highlighting the genetic elements that underlie the persistence of these plasmids within the clinical E. coli population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.