Evidence map›Paper›PMID 35993544›Full record

ArticleeLife2022

Botulinum neurotoxin accurately separates tonic vs. phasic transmission and reveals heterosynaptic plasticity rules in

Yifu Han, Chun Chien, Pragya Goel, Kaikai He, Cristian Pinales, Christopher Buser, Dion Dickman

Abstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
  2. Article
  3. Temporal and Cell-Specific Regulation of Synaptic Homeostasis by the Chromatin Remodeler Chd1.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Nonionic signaling rapidly remodels postsynaptic DLG to induce retrograde homeostatic plasticity.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. CaSTAR protocols · 2024
    Article
  15. Neuromuscular basis ofProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  16. Article
  17. Article
  18. Physiologic and Nanoscale Distinctions Define Glutamatergic Synapses in Tonic vs Phasic Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yifu HanDepartment of Neurobiology, University of Southern California, Los Angeles, United States.ORCID 0000-0002-1201-654X
Chun ChienDepartment of Neurobiology, University of Southern California, Los Angeles, United States.
Pragya GoelDepartment of Neurobiology, University of Southern California, Los Angeles, United States.
Kaikai HeDepartment of Neurobiology, University of Southern California, Los Angeles, United States.
Cristian PinalesOak Crest Institute of Science, Monrovia, United States.ORCID 0000-0002-0826-5308
Christopher BuserOak Crest Institute of Science, Monrovia, United States.ORCID 0000-0002-4379-3878
Dion DickmanDepartment of Neurobiology, University of Southern California, Los Angeles, United States.ORCID 0000-0003-1884-284X

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
Molecular Mechanisms Governing the Homeostatic Control of Synaptic StrengthR01NS091546 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DICKMAN, DION KAI · 2015 to 2024
$4.3M
Generating functional diversity from molecular homogeneity at glutamatergic synapsesR01NS126654 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DION KAI DICKMAN · 2023 to 2026
$1.8M
Synaptic Control of Glutamate HomeostasisR01NS111414 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DICKMAN, DION KAI · 2019 to 2023
$1.8M
NIH HHS P40 OD018537NINDS NIH HHS R01 NS091546NINDS NIH HHS R01 NS111414NINDS NIH HHS R01 NS126654
6 · The paper itself

Abstract

In developing and mature nervous systems, diverse neuronal subtypes innervate common targets to establish, maintain, and modify neural circuit function. A major challenge towards understanding the structural and functional architecture of neural circuits is to separate these inputs and determine their intrinsic and heterosynaptic relationships. The

Indexed as

Botulinum ToxinsAnimalsDrosophilaMotor NeuronsNeuromuscular JunctionNeuronal PlasticitySynaptic TransmissionBotulinum Toxinsbotulinum toxinD. melanogasterDrosophilaneuromuscular junctionneurosciencephasicsynaptic plasticitytonic pathways

Identifiers

PMID35993544
PMCPMC9439677

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.