Evidence map›Paper›PMID 35993520›Full record

ArticleAmerican journal of physiology. Cell physiology2022

FXYD3 facilitates Na

Camilo Cano Portillo, Raul Villacreses, Andrew L Thurman, Alejandro A Pezzulo, Joseph Zabner, Ian M Thornell

Open access · hybridAbstract read
In one paragraph

Article in American journal of physiology. Cell physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Camilo Cano PortilloDepartment of Internal Medicine, Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa.
Raul VillacresesDepartment of Internal Medicine, Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa.
Andrew L ThurmanDepartment of Internal Medicine, Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa.
Alejandro A PezzuloDepartment of Internal Medicine, Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa.ORCID 0000-0001-7544-5109
Joseph ZabnerDepartment of Internal Medicine, Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa.
Ian M ThornellDepartment of Internal Medicine, Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa.ORCID 0000-0001-5535-2925
University of Iowa · US

Funding

Respiratory virus infection in early cystic fibrosis lung diseaseP01HL091842 · NHLBI · UNIVERSITY OF IOWA · PI STOLTZ, DAVID A · 2008 to 2022
$34.2M
Vector Core-Core 2P30DK054759 · NIDDK · UNIVERSITY OF IOWA · PI Alejandro Antonio Pezzulo · 1998 to 2026
$30.5M
Pathology CoreP01HL152960 · NHLBI · UNIVERSITY OF IOWA · PI MCCRAY, PAUL B · 2020 to 2024
$11.6M
Epigenetic mechanisms of inflammatory memory propagation in human airway epitheliaR01HL163024 · NHLBI · UNIVERSITY OF IOWA · PI Alejandro Antonio Pezzulo · 2022 to 2026
$2.8M
Heat-shock protein 90 modulates goblet cell metaplasia in human airway epitheliaK01HL140261 · NHLBI · UNIVERSITY OF IOWA · PI PEZZULO, ALEJANDRO ANTONIO · 2019 to 2023
$746k
NHLBI NIH HHS K01 HL140261NHLBI NIH HHS P01 HL091842NHLBI NIH HHS P01 HL152960NHLBI NIH HHS R01 HL163024NIDDK NIH HHS P30 DK054759
6 · The paper itself

Abstract

Na/K ATPase activity is essential for ion transport across epithelia. FXYD3, a γ subunit of the Na/K ATPase, is expressed in the airway, but its function remains undetermined. Single-cell RNA sequencing and immunohistochemistry revealed that FXYD3 localizes within the basolateral membrane of all airway epithelial cells. To study FXYD3 function, we reduced

Indexed as

AmilorideOuabainHumansMembrane ProteinsNeoplasm ProteinsNystatinRNA, Small InterferingSodiumSodium-Potassium-Exchanging ATPaseAmilorideFXYD3 protein, humanMembrane ProteinsNeoplasm ProteinsNystatinOuabainRNA, Small InterferingSodiumSodium-Potassium-Exchanging ATPaseairwayepitheliaion transport

Identifiers

PMID35993520
PMCPMC9529271
OpenAlexW4292595856

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.