Evidence map›Paper›PMID 35993514›Full record

ArticleAmerican journal of physiology. Cell physiology2022

Corneal dystrophy mutations R125H and R804H disable SLC4A11 by altering the extracellular pH dependence of the intracellular pK that governs H

Bianca N Quade, Aniko Marshall, Mark D Parker

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Cell physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Biomolecules · 2025
    Review
  3. NHFrontiers in physiology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Bianca N QuadeDepartment of Physiology and Biophysics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, New York.ORCID 0000-0002-4488-6056
Aniko MarshallDepartment of Physiology and Biophysics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, New York.
Mark D ParkerDepartment of Physiology and Biophysics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, New York.ORCID 0000-0003-1761-5282
University at Buffalo, State University of New York · US

Funding

Investigating the Action and Physiological Role of Slc4a11 in the CorneaR01EY028580 · NEI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI Mark Parker · 2018 to 2026
$3.5M
NEI NIH HHS R01 EY028580
6 · The paper itself

Abstract

Mutations in the H

Indexed as

Anion Transport ProteinsAntiportersCorneal Dystrophies, HereditarySymporters4,4'-Diisothiocyanostilbene-2,2'-Disulfonic AcidAnimalsHumansHydrogen-Ion ConcentrationMiceMutation4,4'-Diisothiocyanostilbene-2,2'-Disulfonic AcidAnion Transport ProteinsAntiportersSLC4A11 protein, humanSlc4a11 protein, mouseSymportersacid-baseBTR1corneafluid transportproton

Identifiers

PMID35993514
PMCPMC9484998
OpenAlexW4292595546

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.