Evidence map›Paper›PMID 35993496›Full record

ArticleChemical biology & drug design2023

C2-linked alkynyl poly-ethylene glycol(PEG) adenosine conjugates as water-soluble adenosine receptor agonists.

Lindsay Ferguson, Nasrin Shokrzadeh Madieh, Alexandra Vaideanu, Andreas Schatzlein, Joseph Festa, Harprit Singh, Geoffrey Wells, Sanjib Bhakta, Federico Brucoli

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical biology & drug design, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Synthesis of Adenine Nucleosides with a Reactive (Molecules (Basel, Switzerland) · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Lindsay FergusonSchool of Science, University of the West of Scotland, Paisley, UK.
Nasrin Shokrzadeh MadiehLeicester School of Pharmacy, De Montfort University, Leicester, UK.
Alexandra VaideanuUCL School of Pharmacy, University College London, London, UK.
Andreas SchatzleinUCL School of Pharmacy, University College London, London, UK.
Joseph FestaLeicester School of Allied Health Sciences, De Montfort University, Leicester, UK.
Harprit SinghLeicester School of Allied Health Sciences, De Montfort University, Leicester, UK.ORCID 0000-0003-2337-3523
Geoffrey WellsUCL School of Pharmacy, University College London, London, UK.
Sanjib BhaktaDepartment of Biological Sciences, Institute of Structural and Molecular Biology, Birkbeck, University of London, London, UK.ORCID 0000-0002-1165-9295
Federico BrucoliLeicester School of Pharmacy, De Montfort University, Leicester, UK.ORCID 0000-0001-8661-2910
De Montfort University · GBUniversity College London · GBInstitute of Structural and Molecular Biology · GBUniversity of the West of Scotland · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A series of 12 novel polyethylene-glycol(PEG)-alkynyl C2-adenosine(ADN) conjugates were synthesized using a robust Sonogashira coupling protocol and characterized by NMR spectroscopy and mass spectrometry analysis. The ADN-PEG conjugates showed null to moderate toxicity in murine macrophages and 12c was active against Mycobacterium aurum growth (MIC = 62.5 mg/L). The conjugates were not active against Mycobacterium bovis BCG. Conjugates 10b and 11b exhibited high water solubility with solubility values of 1.22 and 1.18 mg/ml, respectively, in phosphate buffer solutions at pH 6.8. Further, 10b and 11b induced a significant increase in cAMP accumulation in RAW264.7 cells comparable with that induced by adenosine. Analogues 10c, 11c and 12c were docked to the A

Indexed as

AdenosinePurinergic P1 Receptor AgonistsAnimalsMicePolyethylene GlycolsProtein BindingReceptor, Adenosine A2AReceptor, Adenosine A3Receptors, Purinergic P1AdenosinePolyethylene GlycolsPurinergic P1 Receptor AgonistsReceptor, Adenosine A2AReceptor, Adenosine A3Receptors, Purinergic P1adenosine receptor agonistsanti-mycobacterial activityNMR spectroscopypoly-ethylene glycolpurinergic receptorSonogashira cross-coupling reaction

Identifiers

PMID35993496
PMCPMC10087458
OpenAlexW4289745429

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.