ArticlePsychological medicine2023
Cross-generational transmission of genetic risk for alcohol and drug use disorders: the impact of substance availability on the specificity of genetic risk.
Article in Psychological medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Subjective response to alcohol: Interactive effects of early life stress, parental risk for mood and substance use disorders, and drinking context.Pharmacology, biochemistry, and behavior · 2023Trial
- Genetic nurture in intergenerational transmission of substance use.Nature communications · 2026Article
- Risk of substance use disorders in the adult children of parents with severe alcohol use disorder: a nationwide cohort study.BMC public health · 2025Article
- Socioenvironmental and mental health determinants of alcohol use among Black sexually minoritized men and transgender women: Findings from the N2 cohort study.Journal of gay & lesbian mental health · 2025Article
- What is the role of paternal genetic transmission on risk for PTSD and internalizing and externalizing disorders?Psychological medicine · 2025Article
- The familial aggregation and co-aggregation of drug use disorder and alcohol use disorder in siblings of affected individuals born 1950-1990: A birth cohort exposed to rising rates of drug use disorder.Psychological medicine · 2025Article
- Global trends and inequalities in the burden of drug use disorders: a comprehensive analysis from 1990 to 2021 with future projections.Frontiers in public health · 2025Article
- Family and personal factors predisposing adolescents to substance abuse in high-risk urban areas.PloS one · 2025Article
- Posttraumatic stress disorder and its cross-generational familial relationship with drug use disorder and alcohol use disorder: an extended Swedish adoption study.European journal of psychotraumatology · 2024Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundAmong individuals with alcohol use disorder (AUD) and drug use disorder (DUD), is their genetic liability and its specificity moderated by substance availability?
methodsOffspring (born 1960-1995) and their biological parents from three family types [not-lived-with (NLW) biological father, mother and adoptive] and their AUD and DUD diagnoses were ascertained from Swedish national registers. Parent-offspring resemblance was calculated by tetrachoric correlation.
resultsIn Swedes born from 1960 to 1995, prevalence rates of AUD were stable while DUD rates increased substantially. Best-estimate tetrachoric correlations (±95% confidence intervals) between AUD in biological parents and AUD and DUD in their offspring were, respectively, +0.19 (0.18-0.20) and +0.18 (0.17-0.20). Parallel results from DUD in parents to AUD and DUD in children were +0.12 (0.10-0.13) and +0.27 (0.26-0.28). When divided into older and younger cohorts, the specificity of DUD transmission increased substantially over time, while the genetic correlation between AUD and DUD significantly decreased.
conclusionsRaised when alcohol was the preferred substance of abuse and illicit drugs highly stigmatized, AUD in parents reflected a general liability to substance use disorders, as they transmitted similar genetic risk for AUD and DUD to their children raised when both substances were widely available and relatively acceptable. DUD in parents, by contrast, reflected a more specific liability to DUD and, when transmitted to offspring, produced a considerably stronger risk for DUD than for AUD that increased over time. The magnitude and specificity of the genetic liability to psychoactive substances can be influenced by the availability of that substance.
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