ArticleThe journal of histochemistry and cytochemistry : official journal of the Histochemistry Society2022
Tuft Cells Are Present in Submandibular Glands Across Species.
Article in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 7 citations in OpenAlex.
- A Mouthful of Genomic Data: Single-Cell Insights into Salivary Gland Biology and Disease.Biology · 2026Review
- Article
- Tuft cells contribute to the pathogenesis of human primary and experimental murine Sjögren's disease.Journal of dental sciences · 2026Article
- Differential expression of haematopoietic prostaglandin D synthase by POU2F3‑positive tuft cells in conventional bilayered oncocytic and metaplastic epithelia of Warthin tumours.Molecular medicine reports · 2025Article
- Intestinal tuft cell immune privilege enables norovirus persistence.Science immunology · 2024Article
- Expression of FOXI1 and POU2F3 varies among different salivary gland neoplasms and is higher in Warthin tumor.Discover oncology · 2024Article
- High-Resolution Transcriptomic Landscape of the Human Submandibular Gland.Journal of dental research · 2023Article
- Confirming the Identity of Tuft Cells in Mouse Submandibular Glands.Gastro hep advances · 2023Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Tuft cells are bottle-shaped, microvilli-projecting chemosensory cells located in the lining of a variety of epithelial tissues and, following their identification approximately 60 years ago, have been linked to immune system function in a variety of epithelia. Until recently, Tuft cells had not been convincingly demonstrated to be present in salivary glands with their detection by transmission electron microscopy only shown in a handful of earlier studies using rat salivary glands, and no follow-up work has been conducted to verify their presence in salivary glands of other species. Here, we demonstrate that Tuft cells are present in the submandibular glands of various species (i.e., mouse, pig and human) using transmission electron microscopy and confocal immunofluorescent analysis for the POU class 2 homeobox 3 (POU2F3), which is considered to be a master regulator of Tuft cell identity.
Indexed as
Identifiers
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Registered trials
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