Evidence map›Paper›PMID 35993094›Full record

ArticleSAGE open medicine2022

Accuracy of GenoQuick MTB test in detection of

Sylvia Kaswabuli, Emmanuel Musisi, Patrick Byanyima, Abdul Sessolo, Ingvar Sanyu, Josephine Zawedde, William Worodria, Laurence Huang, Alfred Okeng, Freddie Bwanga

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in SAGE open medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Real-time evaluation of macozinone activity againstAntimicrobial agents and chemotherapy · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Sylvia KaswabuliInfectious Diseases Research Collaboration, Kampala, Uganda.ORCID https://orcid.org/0000-0003-1133-7349
Emmanuel MusisiDivision of Infection and Global Health, School of Medicine, University of St Andrews, St Andrews, UK.
Patrick ByanyimaInfectious Diseases Research Collaboration, Kampala, Uganda.
Abdul SessoloInfectious Diseases Research Collaboration, Kampala, Uganda.
Ingvar SanyuInfectious Diseases Research Collaboration, Kampala, Uganda.
Josephine ZaweddeInfectious Diseases Research Collaboration, Kampala, Uganda.
William WorodriaInfectious Diseases Research Collaboration, Kampala, Uganda.
Laurence HuangInfectious Diseases Research Collaboration, Kampala, Uganda.
Alfred OkengMBN Clinical Laboratories, Kampala, Uganda.
Freddie BwangaDepartment of Medical Microbiology, Makerere University College of Health Sciences, Kampala, Uganda.ORCID https://orcid.org/0000-0002-8898-0992
Infectious Diseases Research Collaboration · UGJoint Clinical Research Centre · UGMakerere University · UGUniversity of California, San Francisco · USUniversity of St Andrews · GB

Funding

Inflammation, Aging, Microbes, Obstructive Lung Disease and Diffusion Abnormalities (I AM OLD-DA) Study - Diversity SupplementR01HL128156 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUANG, LAURENCE, HUNT, PETER W · 2015 to 2024
$7.1M
International HIV-associated Opportunistic Pneumonias (IHOP) StudyR01HL090335 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUANG, LAURENCE · 2007 to 2011
$4.0M
TB and Other Pulmonary Complications of AIDS Research Training ProgramD43TW009607 · FIC · YALE UNIVERSITY · PI DAVIS, JOHN LUCIAN, KATAMBA, ACHILLES · 2013 to 2022
$3.2M
Patient-Oriented Research and Mentoring in PneumocystisK24HL087713 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUANG, LAURENCE · 2006 to 2018
$1.8M
FIC NIH HHS D43 TW009607NHLBI NIH HHS K24 HL087713NHLBI NIH HHS R01 HL090335NHLBI NIH HHS R01 HL128156
6 · The paper itself

Abstract

Objective: The objective of the study was to determine the diagnostic performance of the GenoQuick MTB test on heated sputum against the conventional Lowenstein-Jensen Introduction: Fast, reliable, and easy-to-use tests for tuberculosis diagnosis are essential to achieving the Sustainable Development Goal of diagnosing and treating 90% of tuberculosis patients by 2030. We evaluated the diagnostic performance of the GenoQuick MTB, a polymerase chain reaction-lateral flow test, in Uganda, a resource-constrained, high tuberculosis- and HIV-burden setting. Methods: Fresh sputum samples from presumptive tuberculosis patients at Mulago Hospital were tested for Results: Of the 86 tested samples, 30.2% had culture-confirmed pulmonary tuberculosis. Overall, sensitivity was higher for GenoQuick MTB (81%, 95% confidence interval: 60%-93%) than for smear microscopy (69%, 95% confidence interval: 48%-86%). Among people living with HIV, sensitivity was identical for GenoQuick MTB and smear tests (75%, 95% confidence interval: 42%-95%). Contrastingly, smear had a higher overall specificity (98%, 95% confidence interval: 91%-100%) than for GenoQuick MTB (92%, 95% confidence interval: 81%-97%). A similar trend of specificity was observed among the people living with HIV for smear microscopy (100%, 95% CI: 87%-100%) and for GenoQuick MTB (96%, 95% confidence interval: 81%-100%). Conclusion: The GenoQuick MTB test could be a potential tuberculosis diagnostic test given its higher sensitivity. Evaluation of this test in larger studies is recommended.

Indexed as

and resource-limited settingsDiagnosisdiagnostic accuracyGenoQuick MTBMycobacterium tuberculosisnucleic acid amplification

Identifiers

PMID35993094
PMCPMC9386833
OpenAlexW4291952052

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.