Evidence map›Paper›PMID 35993020›Full record

ArticleOxidative medicine and cellular longevity2022

Downregulation of Inflammatory Response via Nrf2/Trx1/TXNIP Axis in Oxidative Stress-Induced ARPE-19 Cells and Mouse Model of AMD.

Qian Yang, Wenting Cai, Huizi Jin, Tianyi Shen, Jing Yu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oxidative medicine and cellular longevity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Loss of Peroxiredoxin 6 Drives Age-Related Klf9/NF-Antioxidants (Basel, Switzerland) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Qian YangDepartment of Ophthalmology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China.ORCID https://orcid.org/0000-0001-5906-6221
Wenting CaiDepartment of Ophthalmology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China.ORCID https://orcid.org/0000-0002-2880-302X
Huizi JinDepartment of Ophthalmology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China.ORCID https://orcid.org/0000-0001-9993-4396
Tianyi ShenDepartment of Ophthalmology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China.ORCID https://orcid.org/0000-0003-4393-368X
Jing YuDepartment of Ophthalmology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China.ORCID https://orcid.org/0000-0002-4899-0467
Tongji University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aim: Chronic inflammation is crucial for age-related macular degeneration (AMD) pathogenesis. However, the mechanism involved in activating inflammation remains unclear. This study is aimed at investigating whether nuclear factor erythrocyte-associated factor 2 (Nrf2) negatively regulated the Nod-like receptor protein 3 (NLRP3) inflammasomes through the thioredoxin 1 (Trx1)/thioredoxin interaction protein (TXNIP) complex. Methods: We determined the optimal hydrogen peroxide (H Results: The oxidative stress model was established after 1 h intervention with 100 Conclusions: Nrf2 showed antioxidant and anti-inflammatory activity in the H

Indexed as

Carrier ProteinsMacular DegenerationNF-E2-Related Factor 2ThioredoxinsAnimalsDisease Models, AnimalDown-RegulationHumansHydrogen PeroxideInflammasomesInflammationMiceNLR Family, Pyrin Domain-Containing 3 ProteinOxidative StressReactive Oxygen SpeciesRetinal DiseasesCarrier ProteinsHydrogen PeroxideInflammasomesNFE2L2 protein, humanNfe2l2 protein, mouseNF-E2-Related Factor 2NLR Family, Pyrin Domain-Containing 3 ProteinReactive Oxygen SpeciesThioredoxinsTxn1 protein, mouseTXNIP protein, humanTxnip protein, mouseTXN protein, human

Identifiers

PMID35993020
PMCPMC9391142
OpenAlexW4290879680

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.