Evidence map›Paper›PMID 35993019›Full record

ArticleOxidative medicine and cellular longevity2022

The Mechanism of TNF-

Lin Zhang, Hong Song, Jie Ding, Dong-Jie Wang, Shi-Peng Zhu, Chi Liu, Xian Jin, Jia-Wei Chen

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oxidative medicine and cellular longevity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Lin ZhangDepartment of Anesthesiology, Jing'an District Central Hospital of Shanghai, Fudan University, No259 XiKang Road, Shanghai 200040, China.
Hong SongDepartment of Critical Care Medicine, Jing'an District Central Hospital of Shanghai, Fudan University, No259 XiKang Road, Shanghai 200040, China.
Jie DingDepartment of Anesthesiology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, No270 DongAn Road, Shanghai 200032, China.
Dong-Jie WangDepartment of Anesthesiology, Jing'an District Central Hospital of Shanghai, Fudan University, No259 XiKang Road, Shanghai 200040, China.
Shi-Peng ZhuDepartment of Anesthesiology, Jing'an District Central Hospital of Shanghai, Fudan University, No259 XiKang Road, Shanghai 200040, China.
Chi LiuDepartment of Geriatrics Center, National Clinical Research Center for Aging and Medicine, Jing'an District Central Hospital of Shanghai, Fudan University, No259 XiKang Road, Shanghai 200040, China.ORCID https://orcid.org/0000-0002-7710-7792
Xian JinDepartment of Critical Care Medicine, Jing'an District Central Hospital of Shanghai, Fudan University, No259 XiKang Road, Shanghai 200040, China.ORCID https://orcid.org/0000-0002-7043-7203
Jia-Wei ChenDepartment of Anesthesiology, Jing'an District Central Hospital of Shanghai, Fudan University, No259 XiKang Road, Shanghai 200040, China.ORCID https://orcid.org/0000-0003-3726-9823
Fudan University · CNFudan University Shanghai Cancer Center · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Neuroinflammation-induced phosphorylated Tau (p-Tau) deposition in central nervous system contributes to neurodegenerative disorders. Propofol possesses neuroprotective properties. We investigated its impacts on tumor necrosis factor- Methods: Mouse hippocampal neurons were exposed to propofol followed by TNF- Results: TNF- Conclusions: In hippocampal neurons, TNF-

Indexed as

MitophagyNF-E2-Related Factor 2Propofoltau ProteinsTranscription Factor TFIIHTumor Necrosis Factor-alphaAnimalsGlycogen Synthase Kinase 3 betaHippocampusKelch-Like ECH-Associated Protein 1MiceNeuronsNLR Family, Pyrin Domain-Containing 3 ProteinNLR ProteinsPhosphorylationReactive Oxygen SpeciesGlycogen Synthase Kinase 3 betaGtf2h1 protein, mouseKeap1 protein, mouseKelch-Like ECH-Associated Protein 1Nfe2l2 protein, mouseNF-E2-Related Factor 2NLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseNLR ProteinsPropofolReactive Oxygen SpeciesSuperoxide Dismutasetau ProteinsTranscription Factor TFIIHTumor Necrosis Factor-alpha

Identifiers

PMID35993019
PMCPMC9391138
OpenAlexW4290930498

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.