ArticleSovremennye tekhnologii v meditsine2022
Selection of the Optimal Method for Creating Various Forms of Biocompatible Xenodermal Materials.
Article in Sovremennye tekhnologii v meditsine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed, 1 citations in OpenAlex.
- In Vitro and In Vivo Testing of Decellularized Lung and Pancreas Matrices as Potential Islet Platforms.International journal of molecular sciences · 2025Article
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6 authors at 4 institutions in 5 countries.
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No grant is acknowledged in the PubMed record.
Abstract
Materials and Methods: To create xenodermal biomaterials, the native skin of a 4-month-old Landrace pig was used. The porcine dermis was processed with saline (protocol No.1), peroxide-alkaline (protocol No.2), and alkaline (protocol No.3) solutions. The obtained samples were stained with hematoxylin-eosin and a DAPI fluorescent dye. Quantitative DNA analysis and assessment of cytotoxicity by the LIVE/DEAD assay were also performed. Samples were implanted/injected subcutaneously to 6-month-old male Wistar rats (n=30) weighing 260±20 g and explanted on day 14 of the experiment. Histological sections were stained with hematoxylin-eosin. Computer morphometry was performed using GraphPad Prism v. 6.04. Results: Samples of surgical materials obtained according to the three protocols had different physical characteristics: dermis treated according to protocol No.1 was dense and white in color after processing; samples processed by protocol No.2 were transparent and dense, and samples treated according to protocol No.3 had transparent gel-like structures. Histological analysis has shown oxyphilicity and extracellular matrix structure loss in all samples, and DAPI staining has revealed the destruction of cell nuclei. Nevertheless, DNA amount in the samples processed according to protocol No.1 did not meet the established quality criterion for decellularization (50 ng/mg dry weight). Further cytotoxicity assessment Conclusion: To obtain surgical materials in the form of bioplastic coatings, it is recommended to use alkaline-peroxide treatment of the dermis, while hydrogel coatings are produced by alkaline hydrolysis.
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