ArticleFrontiers in human neuroscience2022
Exploration of abnormal dynamic spontaneous brain activity in patients with high myopia
Article in Frontiers in human neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- The Eye-Brain Axis in High Myopia: From Retinal Deformation to Cortical Network Reorganization.Eye and brain · 2026Review
- The neural signature of high myopia: structural and functional brain alterations and their cognitive-emotional associations.Frontiers in cell and developmental biology · 2025Review
- Update on central factors in myopia development beyond intraocular mechanisms.Frontiers in neurology · 2024Review
- Exploration of static functional connectivity and dynamic functional connectivity alterations in the primary visual cortex among patients with high myopiaFrontiers in neuroscience · 2023Article
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Authors and funding
7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Aim: Patients with high myopia (HM) reportedly exhibit changes in functional brain activity, but the mechanism underlying such changes is unclear. This study was conducted to observe differences in dynamic spontaneous brain activity between patients with HM and healthy controls (HCs) Methods: Resting-state functional magnetic resonance imaging (rs-fMRI) scans were performed on 82 patients with HM and 59 HCs who were closely matched for age, sex, and weight. The dReHo approach was used to assess local dynamic activity in the human brain. The association between mean dReHo signal values and clinical symptoms in distinct brain areas in patients with HM was determined Results: In the left fusiform gyrus (L-FG), right inferior temporal gyrus (R-ITG), right Rolandic operculum (R-ROL), right postcentral gyrus (R-PoCG), and right precentral gyrus (R-PreCG), dReHo values were significantly greater in patients with HM than in HCs. Conclusion: Patients with HM have distinct functional changes in various brain regions that mainly include the L-FG, R-ITG, R-ROL, R-PoCG, and R-PreCG. These findings constitute important evidence for the roles of brain networks in the pathophysiological mechanisms of HM and may aid in the diagnosis of HM.
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