Evidence map›Paper›PMID 35992948›Full record

SynthesisFrontiers in human neuroscience2022

What names for covert awareness? A systematic review.

Caroline Schnakers, Chase Bauer, Rita Formisano, Enrique Noé, Roberto Llorens, Nicolas Lejeune, Michele Farisco, Liliana Teixeira, Ann-Marie Morrissey, Sabrina De Marco and 8 more

Abstract readSystematic Review
In one paragraph

Synthesis in Frontiers in human neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Emergence from Disorders of Consciousness: Optimizing Self-Agency Through Communication.Physical medicine and rehabilitation clinics of North America · 2024
    Review
  15. Article
  16. Article
  17. Article
  18. Covert consciousness.NeuroRehabilitation · 2024
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Caroline SchnakersResearch Institute, Casa Colina Hospital and Centers for Healthcare, Pomona, CA, United States.
Chase BauerCollege of Osteopathic Medicine, Western University of Health Sciences, Pomona, CA, United States.
Rita FormisanoIRCCS Santa Lucia Foundation, Rome, Italy.
Enrique NoéVithas Neuro Rehab Human Brain, Fundación Hospitales Vithas, Valencia, Spain.
Roberto LlorensVithas Neuro Rehab Human Brain, Fundación Hospitales Vithas, Valencia, Spain.
Nicolas LejeuneCentre Hospitalier Neurologique William Lennox, Ottignies-Louvain-la-Neuve, Belgium.
Michele FariscoCentre for Research Ethics and Bioethics, Uppsala University, Uppsala, Sweden.
Liliana TeixeiraCenter for Innovative Care and Health Technology, School of Health Sciences, Polytechnic of Leiria, Leiria, Portugal.
Ann-Marie MorrisseyAgeing Research Centre, School of Allied Health, Health Research Institute, University of Limerick, Limerick, Ireland.
Sabrina De MarcoClínica Universitaria Reina Fabiola, Universidad Católica de Córdoba, Córdoba, Argentina.
Vigneswaran VeeramuthuSubang Jaya Medical Center, Subang Jaya, Malaysia.
Kseniya IlinaResearch Center of Neurology, Moscow, Russia.
Brian L EdlowMassachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Olivia GosseriesGIGA-Consciousness, Coma Science Group, University of Liège, Liege, Belgium.
Matteo ZandalasiniUnità Spinale, Neuroriabilitazione e Medicina Riabilitativa Intensiva, Dipartimento di Medicina Riabilitativa, Azienda USL di Piacenza, Piacenza, Italy.
Francesco De BellisIRCCS Fondazione Don Carlo Gnocchi, Florence, Italy.
Aurore ThibautGIGA-Consciousness, Coma Science Group, University of Liège, Liege, Belgium.
Anna EstraneoIRCCS Fondazione Don Carlo Gnocchi, Florence, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: With the emergence of Brain Computer Interfaces (BCI), clinicians have been facing a new group of patients with severe acquired brain injury who are unable to show any behavioral sign of consciousness but respond to active neuroimaging or electrophysiological paradigms. However, even though well documented, there is still no consensus regarding the nomenclature for this clinical entity. Objectives: This systematic review aims to 1) identify the terms used to indicate the presence of this entity through the years, and 2) promote an informed discussion regarding the rationale for these names and the best candidates to name this fascinating disorder. Methods: The Disorders of Consciousness Special Interest Group (DoC SIG) of the International Brain Injury Association (IBIA) launched a search on Pubmed and Google scholar following PRISMA guidelines to collect peer-reviewed articles and reviews on human adults (>18 years) published in English between 2006 and 2021. Results: The search launched in January 2021 identified 4,089 potentially relevant titles. After screening, 1,126 abstracts were found relevant. Finally, 161 manuscripts were included in our analyses. Only 58% of the manuscripts used a specific name to discuss this clinical entity, among which 32% used several names interchangeably throughout the text. We found 25 different names given to this entity. The five following names were the ones the most frequently used: covert awareness, cognitive motor dissociation, functional locked-in, non-behavioral MCS (MCS Conclusion: Since 2006, there has been no agreement regarding the taxonomy to use for unresponsive patients who are able to respond to active neuroimaging or electrophysiological paradigms. Developing a standard taxonomy is an important goal for future research studies and clinical translation. We recommend a Delphi study in order to build such a consensus.

Indexed as

cognitive motor dissociationconsciousnesscovert awarenessfunctional locked-inminimally conscious statenon-behavioral MCSunresponsive wakefulness syndromevegetative state

Identifiers

PMID35992948
PMCPMC9389234

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.