Evidence map›Paper›PMID 35992904›Full record

ArticleFrontiers in neuroscience2022

High-frequency repetitive transcranial magnetic stimulation improves spatial episodic learning and memory performance by regulating brain plasticity in healthy rats.

Qi Wu, Xingjun Xu, Chenyuan Zhai, Zhiyong Zhao, Wenjun Dai, Tong Wang, Ying Shen

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07547319 (Clinical and Neurophysiological Effects of Accelerated rTMS on Cognitive Function), which is not on this map. Cited by 17 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 4 pooled it
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07547319 narecruitingnot on this mapstarted 2026, after this paper: background citation

Clinical and Neurophysiological Effects of Accelerated rTMS on Cognitive Function: A Prospective Pilot Study

TypeinterventionalSponsorSan Francisco Neurology and Sleep CenterRan2026 to 2027Enrolled80ConditionsCognitive Decline, Cognitive ImpairmentArmsTMS
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 4 syntheses or guidelines pooled it, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Qi WuRehabilitation Medicine Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Xingjun XuRehabilitation Medicine Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Chenyuan ZhaiRehabilitation Medicine Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Zhiyong ZhaoCollege of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China.
Wenjun DaiRehabilitation Medicine Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Tong WangRehabilitation Medicine Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Ying ShenRehabilitation Medicine Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Jiangsu Province Hospital · CNNanjing Medical University · CNZhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Repetitive transcranial magnetic stimulation (rTMS) is an effective way to stimulate changes in structural and functional plasticity, which is a part of learning and memory. However, to our knowledge, rTMS-induced specific activity and neural plasticity in different brain regions that affect cognition are not fully understood; nor are its mechanisms. Therefore, we aimed to investigate rTMS-induced cognition-related neural plasticity changes and their mechanisms in different brain regions. Methods: A total of 30 healthy adult rats were randomly divided into the control group and the rTMS group ( Results: After 4 weeks of rTMS, the cognitive ability of healthy rats who underwent rTMS showed a small but significant behavioral improvement in spatial episodic learning and memory performance. Compared with the pre-rTMS or the control group, rats in the rTMS group showed increased regional homogeneity (ReHo) in multiple brain regions in the interoceptive/default mode network (DMN) and cortico-striatal-thalamic network, specifically the bilateral PFC, bilateral hippocampus, and the left M1. Western blot analyses showed that rTMS led to a significant increase in the expressions of Conclusion: Overall, these data suggested that HF-rTMS can enhance cognitive performance through modulation of NMDA receptor-dependent brain plasticity.

Indexed as

cognitive improvementhealthy ratneural plasticityN-methyl-D-aspartic acid receptorsrepetitive transcranial magnetic stimulationresting-state functional magnetic resonance imaging

Identifiers

PMID35992904
PMCPMC9389218
OpenAlexW4289940635

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.