Evidence map›Paper›PMID 35992862›Full record

ArticleFrontiers in oncology2022

Associations of clinical and circulating metabolic biomarkers with low physical fitness and function in adults with chronic lymphocytic leukemia.

Andrea Sitlinger, Michael A Deal, Erwin Garcia, Margery Connelly, Dana Thompson, Tiffany Stewart, Grace Macdonald, Erik D Hanson, Megan Neely, Ben Neely and 4 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06987708 (Evaluating the Impact of a 12-month Multi-Modal Lifestyle Management Intervention on Disease Relevant Biomarkers Associated With Monoclonal Gammopathy of Unknown Significance), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06987708 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Evaluating the Impact of a 12-month Multi-Modal Lifestyle Management Intervention on Disease Relevant Biomarkers Associated With Monoclonal Gammopathy of Unknown Significance (MGUS) and Smoldering Myeloma (SM): A Prospective Intervention Pilot Study

TypeinterventionalSponsorHackensack Meridian HealthRan2026 to 2028Enrolled67ConditionsMonoclonal Gammopathy of Uncertain Significance, Smoldering MyelomaArmsThe Multimodal Lifestyle Intervention
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Andrea SitlingerHematologic Malignancies and Cellular Therapies, Duke University Medical Center, Durham, NC, United States.
Michael A DealDivision of Medical Oncology, Duke University Medical Center, Durham, NC, United States.
Erwin GarciaLaboratory Corporation of America Holdings (Labcorp), Morrisville, NC, United States.
Margery ConnellyLaboratory Corporation of America Holdings (Labcorp), Morrisville, NC, United States.
Dana ThompsonDivision of Hematology, Duke University Medical Center and VA Medical Center, Durham, NC, United States.
Tiffany StewartDivision of Hematology, Duke University Medical Center and VA Medical Center, Durham, NC, United States.
Grace MacdonaldDivision of Medical Oncology, Duke University Medical Center, Durham, NC, United States.
Erik D HansonDepartment of Exercise and Sport Science, University of North Carolina, Chapel Hill, NC, United States.
Megan NeelyDepartment of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC, United States.
Ben NeelyDepartment of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC, United States.
Ashley ArteseDuke University Aging Center, Duke University Medical Center, Durham, NC, United States.
J Brice WeinbergDivision of Hematology, Duke University Medical Center and VA Medical Center, Durham, NC, United States.
Danielle BranderHematologic Malignancies and Cellular Therapies, Duke University Medical Center, Durham, NC, United States.
David B BartlettDivision of Medical Oncology, Duke University Medical Center, Durham, NC, United States.
Duke Medical Center · USDuke University Hospital · USLabCorp (United States) · USUniversity of North Carolina at Chapel Hill · US

Funding

Resource Core 3 - Metabolomics CoreP30AG028716 · NIA · DUKE UNIVERSITY · PI Virginia B Kraus · 2006 to 2026
$24.6M
TRANSFUSION MEDICINE AND RELATED AREAST32HL007057 · NHLBI · DUKE UNIVERSITY · PI Gowthami M Arepally · 1985 to 2026
$10.6M
NHLBI NIH HHS T32 HL007057NIA NIH HHS P30 AG028716
6 · The paper itself

Abstract

Many patients with chronic lymphocytic leukemia (CLL) experience physical dysfunction and low overall fitness. It remains unknown what factors drive CLL physical dysfunction. We assessed physical function and metabolic lipoprotein panels in 106 patients with CLL. In univariate analyses of clinical factors, a longer time since diagnosis was associated with a higher likelihood of dysfunctional aerobic fitness (OR = 3.56, 95% CI: 1.37-9.22;

Indexed as

chronic lymphocytic leukemia (CLL)lipids and lipoproteinsmetabolismphysical fitnessphysical function

Identifiers

PMID35992862
PMCPMC9381973
OpenAlexW4289517231

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.