Evidence map›Paper›PMID 35992763›Full record

ArticleCanadian liver journal2019

Stability of hepatitis B viral load during pregnancy and implications for antepartum prophylaxis: A prospective cohort study.

Clara Van Ommen, Arianne Albert, Melica Nourmoussavi, Reka Gustafson, Elizabeth Brodkin, Martin Petric, Mel Krajden, Jane A Buxton, Mark Bigham, Neora Pick and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Canadian liver journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Clara Van OmmenFaculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Arianne AlbertWomen's Health Research Institute, Vancouver, British Columbia, Canada.
Melica NourmoussaviDepartment of Obstetrics and Gynaecology, University of Montreal, Montreal, Quebec, Canada.
Reka GustafsonSchool of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada.
Elizabeth BrodkinOffice of the Medical Health Officer, Fraser Health Authority, Surrey, British Columbia, Canada.
Martin PetricDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Mel KrajdenDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Jane A BuxtonSchool of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada.
Mark BighamSchool of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada.
Neora PickDepartment of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Richard A SchreiberDepartment of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada.
Christopher H SherlockDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Deborah MoneyDepartment of Obstetrics and Gynecology, University of British Columbia, Vancouver, British Columbia, Canada.
Eric M YoshidaDepartment of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Julianne van SchalkwykDepartment of Obstetrics and Gynecology, University of British Columbia, Vancouver, British Columbia, Canada.
University of British Columbia · CAFraser Health · CAUniversité de Montréal · CAWomen's Health Research Institute · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe examined changes in hepatitis B virus (HBV) viral loads (VLs) in pregnancy, their association with hepatitis B e antigen (HBeAg), and the associated infant outcomes.

methodsWe prospectively followed 132 mothers positive for hepatitis B surface antigen (HBsAg) and their 135 infants from 2011 to 2015 in Vancouver, British Columbia. Outcome measures included association between maternal HBeAg and high (>200,000 IU/mL) or low (≤200,000 IU/mL) HBV VL, changes in HBV VL through pregnancy, infant HBsAg status, and infant completion of the HBV vaccination series.

resultsf the 91 participants with an available HBV VL, 13 (14.3%) had an HBV VL of more than 200,000 IU/mL. Of 59 participants with paired HBeAg and HBV VL in pregnancy, 6 had an HBV VL of more than 200,000 IU/mL; of interest, 2 of the 6 (33.3%) were HBeAg-negative. Thirty-eight participants had HBV VL results at both mid-trimester and delivery. For these 38 participants, Wilcoxon signed-ranks test for paired data found that an HBV VL remained stable (

conclusionsOur study demonstrates that HBeAg and HBV VL are not reliably predictive of each other. This supports the improved predictive value of VL measurement in pregnancy to risk stratify pregnant patients to offer antiviral treatment when indicated and further minimize the risk of perinatal transmission.

Indexed as

antiviralshepatitis B virusperinatal transmissionpregnancyvirus

Identifiers

PMID35992763
PMCPMC9202810
OpenAlexW2980958679

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.