ArticleInfection and drug resistance2022
Nasopharyngeal Carriage and Antibiogram of Pneumococcal and Other Bacterial Pathogens from Children with Sickle Cell Disease in Tanzania.
Article in Infection and drug resistance, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Antimicrobial susceptibility pattern of Staphylococcus Aureus isolated from clinical specimens at University of Gondar comprehensive specialized referral hospital northwest Ethiopia; a retrospective study.BMC research notes · 2025Article
- Sickle Cell Disease and Antimicrobial Resistance: A Systematic Review and Meta-Analysis.Infectious disease reports · 2025Review
- Article
- Bacterial isolates, antibiotic susceptibility, and determinants of positive blood culture in children with community-acquired pneumonia in Central Tanzania.The Pan African medical journal · 2025Article
- Prevalence, Etiological Patterns and Factors Associated with Bacteraemia Among Febrile Children with Sickle Cell Anaemia in Jinja Regional Referral Hospital, Uganda.Infection and drug resistance · 2025Article
- Childhood vaccination trends during 2019 to 2022 in Tanzania and the impact of the COVID-19 pandemic.Human vaccines & immunotherapeutics · 2024Article
- Article
- Barriers and Facilitators of Availability of Hydroxyurea for Sickle Cell Disease in Tanzania; A Qualitative Study of Pharmaceutical Manufacturers, Importers, and Regulators.Healthcare (Basel, Switzerland) · 2022Article
- Article
- Clinical and microbiological perspectives on multidrug-resistant gram-negative pathogens in bloodstream infections.International journal of critical illness and injury scienceArticle
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
Background: Bacterial infections contribute significantly to morbidity and mortality in sickle cell disease (SCD) patients, particularly children under five years of age. In Tanzania, prophylaxis against pneumococcal infection among children with SCD advocates the use of both oral penicillin V (PV) and pneumococcal vaccines (PNV). Therefore, this study aimed to investigate nasopharyngeal carriage and antibiogram of Methods: This cross-sectional study was undertaken at the two Sickle Pan-African Research Consortium (SPARCO) study sites in Dar es salaam, Tanzania. The study was conducted for six months and enrolled children with SCD between the ages of 6 to 59-months. A semi-structured questionnaire was used to collect patient data. Nasopharyngeal swabs were collected from all participants and cultured for Results: Out of 204 participants, the overall prevalence of bacterial carriage was 53.4%, with Conclusion: There are substantially high nasopharyngeal carriage pathogenic bacteria in children with SCD in Dar es Salaam, Tanzania. The presence of MDR strains to the commonly used antibiotics suggests the need to reconsider optimizing antimicrobial prophylaxis in children with SCD and advocacy on pneumococcal vaccines.
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