Evidence map›Paper›PMID 35992691›Full record

ArticleFrontiers in microbiology2022

A microsatellite DNA-derived oligodeoxynucleotide attenuates lipopolysaccharide-induced acute lung injury in mice by inhibiting the HMGB1-TLR4-NF-κB signaling pathway.

Chenghua Zhang, Hui Wang, Hongrui Wang, Shuyou Shi, Peiyan Zhao, Yingying Su, Hua Wang, Ming Yang, Mingli Fang

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. An underlying mechanism of bovine mastitis: PGEThe veterinary quarterly · 2026
    Article
  2. Transfusion-Related Acute Lung Injury: from Mechanistic Insights to Therapeutic Strategies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Chenghua ZhangDepartment of Molecular Biology, College of Basic Medical Sciences, Jilin University, Changchun, China.
Hui WangDepartment of Molecular Biology, College of Basic Medical Sciences, Jilin University, Changchun, China.
Hongrui WangDepartment of Molecular Biology, College of Basic Medical Sciences, Jilin University, Changchun, China.
Shuyou ShiDepartment of Molecular Biology, College of Basic Medical Sciences, Jilin University, Changchun, China.
Peiyan ZhaoDepartment of Molecular Biology, College of Basic Medical Sciences, Jilin University, Changchun, China.
Yingying SuDepartment of Anatomy, College of Basic Medical Sciences, Jilin University, Changchun, China.
Hua WangDepartment of Molecular Biology, College of Basic Medical Sciences, Jilin University, Changchun, China.
Ming YangDepartment of Molecular Biology, College of Basic Medical Sciences, Jilin University, Changchun, China.
Mingli FangDepartment of Molecular Biology, College of Basic Medical Sciences, Jilin University, Changchun, China.
Jilin Medical University · CNJilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute lung injury (ALI) with uncontrolled inflammatory response has high morbidity and mortality rates in critically ill patients. Pathogen-associated molecular patterns (PAMPs) are involved in the development of uncontrolled inflammatory response injury and associated lethality. In this study, we investigated the inhibit effect of MS19, a microsatellite DNA-derived oligodeoxynucleotide (ODN) with AAAG repeats, on the inflammatory response induced by various PAMPs

Indexed as

acute lung injury (ALI)high-mobility group box 1 (HMGB1)inflammationNF-κB – nuclear factor kappa Boligodeoxynucleotide (ODN)pathogen-associated molecular patterns (PAMPs)

Identifiers

PMID35992691
PMCPMC9386506
OpenAlexW4289838297

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.