ArticleMedicine in novel technology and devices2021
Complications in the spine associated with type 2 diabetes: The role of advanced glycation end-products.
Article in Medicine in novel technology and devices, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Ten-year healthcare utilization patterns among patients with type 2 diabetes and degenerative spinal disorders: a nationwide comparative analysis using nationwide sample.BMC health services research · 2026Article
- Genetic and pharmacologic modulation of RAGE rescues the diabetes-mediated impairments to bone at multiple length scales.bioRxiv : the preprint server for biology · 2026Article
- Effect of comprehensive rehabilitation on pressure pain threshold, functional disability, and plantar pressure among type 2 diabetes mellitus individuals with chronic low back pain.Journal of back and musculoskeletal rehabilitation · 2026Article
- Impact of prediabetes on postoperative outcomes following short-segment transforaminal lumbar interbody fusions.North American Spine Society journal · 2025Article
- The sex-specific effects of RAGE signaling and type 2 diabetes on mouse cortical bone mechanics, structure, and material properties.Mechanobiology in medicine · 2025Article
- Unlocking the connection: hemoglobin glycation index as a key driver of bone loss in diabetes-related osteoporosis.Frontiers in endocrinology · 2025Article
- Exploration of Pharmacological Mechanisms of Dapagliflozin against Type 2 Diabetes Mellitus through PI3K-Akt Signaling Pathway based on Network Pharmacology Analysis and Deep Learning Technology.Current computer-aided drug design · 2025Article
- Protective effects of GuanXinNing tablet (GXNT) on diabetic encephalopathy in zucker diabetic obesity (ZDF) rats.BMC complementary medicine and therapies · 2023Article
- Type 2 diabetes alters the viscoelastic behavior and macromolecular composition of vertebra.Bone reports · 2023Article
- Effects of continuous subcutaneous insulin infusion on the microstructures, mechanical properties and bone mineral compositions of lumbar spines in type 2 diabetic rats.BMC musculoskeletal disorders · 2022Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Type 2 diabetes mellitus (T2D) is an increasingly prevalent disease with numerous comorbidities including many in the spine. T2D is strongly linked with vertebral fractures, intervertebral disc (IVD) degeneration, and severe chronic spinal pain. Yet the causative mechanism for these musculoskeletal impairments remains unclear. The chronic hyperglycemic state in T2D promotes the formation of advanced glycation end-products (AGEs) in tissues, and the accumulation of AGEs may play a role in musculoskeletal complications by modifying the extracellular matrix, impairing cellular homeostasis, and perpetuating an inflammatory cascade via its receptor (RAGE). The AGE and RAGE associated alterations in extracellular matrix composition and morphological features of the vertebral bodies and IVDs are likely contributors to the incidence and severity of spinal pathologies in T2D. This review will broadly examine the effects of AGEs on tissues in the spine in the context of T2D, with an emphasis on the changes in the vertebrae and the IVD. Along with the clinical and epidemiological findings, we will provide an overview of preclinical rodent models of T2D that exhibit deficits in the IVD and vertebral bone. Elucidating the role of AGEs and RAGE will be crucial for understanding the disease mechanisms and translation therapies of musculoskeletal pathologies in T2D.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.