Evidence map›Paper›PMID 35992360›Full record

ReviewFrontiers in bioengineering and biotechnology2022

Perinatal derivatives: How to best characterize their multimodal functions

Ana I Flores, Caterina Pipino, Urška Dragin Jerman, Sergio Liarte, Florelle Gindraux, Mateja Erdani Kreft, Francisco J Nicolas, Assunta Pandolfi, Larisa Tratnjek, Bernd Giebel and 5 more

Abstract readReview
In one paragraph

Review in Frontiers in bioengineering and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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  11. Microneedle-Mediated Delivery of Extracellular Matrix-Inspired Peptides for Mitigation of Burn Wound Progression and Support of Tissue Repair.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ana I FloresRegenerative Medicine Group, Research Institute Hospital 12 de Octubre (imas12), Madrid, Spain.
Caterina PipinoCenter for Advanced Studies and Technology (CAST), Department of Medical, Oral and Biotechnological Sciences, University G. d'Annunzio Chieti-Pescara, StemTech Group, Chieti, Italy.
Urška Dragin JermanUniversity of Ljubljana, Faculty of Medicine, Institute of Cell Biology, Ljubljana, Slovenia.
Sergio LiarteLaboratorio de Regeneración, Oncología Molecular y TGF-β, IMIB-Arrixaca, Murcia, Spain.
Florelle GindrauxService de Chirurgie Maxillo-Faciale, Stomatologie et Odontologie Hospitalière, CHU Besançon, Besançon, France.
Mateja Erdani KreftUniversity of Ljubljana, Faculty of Medicine, Institute of Cell Biology, Ljubljana, Slovenia.
Francisco J NicolasLaboratorio de Regeneración, Oncología Molecular y TGF-β, IMIB-Arrixaca, Murcia, Spain.
Assunta PandolfiCenter for Advanced Studies and Technology (CAST), Department of Medical, Oral and Biotechnological Sciences, University G. d'Annunzio Chieti-Pescara, StemTech Group, Chieti, Italy.
Larisa TratnjekUniversity of Ljubljana, Faculty of Medicine, Institute of Cell Biology, Ljubljana, Slovenia.
Bernd GiebelInstitute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Michela PozzobonDepartment of Women's and Children's Health, University of Padova, Padova, Italy and Foundation Institute of Pediatric Research Fondazione Città Della Speranza, Padova, Italy.
Antonietta R SiliniCentro di Ricerca E. Menni, Brescia, Italy.
Ornella ParoliniDepartment of Life Science and Public Health, Università Cattolica del Sacro Cuore, Rome, Italy.
Günther EissnerSystems Biology Ireland, School of Medicine, Conway Institute, University College Dublin, Dublin, Ireland.
Ingrid Lang-OlipDivision of Cell Biology, Histology and Embryology, Gottfried Schatz Research Center, Medical University of Graz, Graz, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Perinatal derivatives (PnD) are birth-associated tissues, such as placenta, umbilical cord, amniotic and chorionic membrane, and thereof-derived cells as well as secretomes. PnD play an increasing therapeutic role with beneficial effects on the treatment of various diseases. The aim of this review is to elucidate the modes of action of non-hematopoietic PnD on inflammation, angiogenesis and wound healing. We describe the source and type of PnD with a special focus on their effects on inflammation and immune response, on vascular function as well as on cutaneous and oral wound healing, which is a complex process that comprises hemostasis, inflammation, proliferation (including epithelialization, angiogenesis), and remodeling. We further evaluate the different

Indexed as

amniotic epithelial cellsamniotic membraneangiogenesisfunctional assaysinflammationmesenchymal stromal cellsperinatal derivativeswound healing

Identifiers

PMID35992360
PMCPMC9386263

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.