ArticleNational science review2022
Energy landscape decomposition for cell differentiation with proliferation effect.
Article in National science review, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Learning stochastic dynamics and cell-fate landscapes from single-cell snapshots via optimal transport.Science advances · 2026Article
- stVCR: spatiotemporal dynamics of single cells.Nature methods · 2026Article
- Generative models of cell dynamics: from Neural ODEs to flow matching.Communications biology · 2026Review
- Energy landscapes and synergetic state transitions in frustrated Stuart-Landau oscillator networks: a homotopy continuation study.Frontiers in network physiology · 2026Article
- Deciphering cell-fate trajectories using spatiotemporal single-cell transcriptomic data.NPJ systems biology and applications · 2025Review
- Beyond metaphor: quantitative reconstruction of Waddington landscape and exploration of cellular behavior.Briefings in bioinformatics · 2025Review
- Quantifying Individual Health Status from Multi-omics Data by Health State Manifold.Phenomics (Cham, Switzerland) · 2025Article
- Reconstructing Waddington Landscape from Cell Migration and Proliferation.Interdisciplinary sciences, computational life sciences · 2025Article
- Quantifying Landscape and Flux from Single-Cell Omics: Unraveling the Physical Mechanisms of Cell Function.JACS Au · 2025Review
- Integrating Dynamical Systems Modeling with Spatiotemporal scRNA-Seq Data Analysis.Entropy (Basel, Switzerland) · 2025Review
- Two-dimensional Health State Map to define metabolic health using separated static and dynamic homeostasis features: a proof-of-concept study.National science review · 2025Article
- The mathematical exploration for the mechanism of lung adenocarcinoma formation and progression.Briefings in bioinformatics · 2024Article
- Review
- EPR-Net: constructing a non-equilibrium potential landscape via a variational force projection formulation.National science review · 2024Article
- A logic-incorporated gene regulatory network deciphers principles in cell fate decisions.eLife · 2024Article
- Deciphering and integrating invariants for neural operator learning with various physical mechanisms.National science review · 2024Article
- scGIR: deciphering cellular heterogeneity via gene ranking in single-cell weighted gene correlation networks.Briefings in bioinformatics · 2024Article
- Reconstructing growth and dynamic trajectories from single-cell transcriptomics data.Nature machine intelligence · 2024Article
- Coevolutionary insights between promoters and transcription factors in the plant and animal kingdoms.Zoological research · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Complex interactions between genes determine the development and differentiation of cells. We establish a landscape theory for cell differentiation with proliferation effect, in which the developmental process is modeled as a stochastic dynamical system with a birth-death term. We find that two different energy landscapes, denoted
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.