Evidence map›Paper›PMID 35992099›Full record

ArticleFrontiers in endocrinology2022

Dimerization of GPCRs: Novel insight into the role of FLNA and SSAs regulating SST

Donatella Treppiedi, Giusy Marra, Genesio Di Muro, Rosa Catalano, Federica Mangili, Emanuela Esposito, Davide Calebiro, Maura Arosio, Erika Peverelli, Giovanna Mantovani

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Donatella TreppiediDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Giusy MarraDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Genesio Di MuroDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Rosa CatalanoDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Federica MangiliDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Emanuela EspositoDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Davide CalebiroInstitute of Metabolism and Systems Research, University of Birmingham, Birmingham, United Kingdom.
Maura ArosioDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Erika PeverelliDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Giovanna MantovaniDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
University of Milan · ITFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITUniversity of Birmingham · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The process of GPCR dimerization can have profound effects on GPCR activation, signaling, and intracellular trafficking. Somatostatin receptors (SSTs) are class A GPCRs abundantly expressed in pituitary tumors where they represent the main pharmacological targets of somatostatin analogs (SSAs), thanks to their antisecretory and antiproliferative actions. The cytoskeletal protein filamin A (FLNA) directly interacts with both somatostatin receptor type 2 (SST

Indexed as

OctreotidePituitary NeoplasmsAnimalsDimerizationFilaminsHumansRatsSomatostatinFilaminsFLNA protein, humanOctreotideSomatostatinFLNAGPCR dimerizationin situ PLAsomatostatin analogsSST2SST5

Identifiers

PMID35992099
PMCPMC9389162
OpenAlexW4289874704

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.