Evidence map›Paper›PMID 35992071›Full record

ArticleiScience2022

Cochlear ribbon synapse maturation requires Nlgn1 and Nlgn3.

Miguel A Ramirez, Yuzuru Ninoyu, Cayla Miller, Leonardo R Andrade, Seby Edassery, Ewa Bomba-Warczak, Briana Ortega, Uri Manor, Mark A Rutherford, Rick A Friedman and 1 more

Open access · goldAbstract read
In one paragraph

Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
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  10. Article
  11. Presynaptic Nrxn3 is essential for ribbon-synapse assembly in hair cells.bioRxiv : the preprint server for biology · 2024
    Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Miguel A RamirezDepartment of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Yuzuru NinoyuDivision of Otolaryngology, Department of Surgery, University of California, San Diego, 9500 Gilman Drive, Mail Code 0666, La Jolla, CA 92093, USA.
Cayla MillerWaitt Advanced Biophotonics Core, Salk Institute for Biological Studies, 10010 N. Torrey Pines Road, La Jolla, CA 92037, USA.
Leonardo R AndradeWaitt Advanced Biophotonics Core, Salk Institute for Biological Studies, 10010 N. Torrey Pines Road, La Jolla, CA 92037, USA.
Seby EdasseryDepartment of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Ewa Bomba-WarczakDepartment of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Briana OrtegaDivision of Otolaryngology, Department of Surgery, University of California, San Diego, 9500 Gilman Drive, Mail Code 0666, La Jolla, CA 92093, USA.
Uri ManorWaitt Advanced Biophotonics Core, Salk Institute for Biological Studies, 10010 N. Torrey Pines Road, La Jolla, CA 92037, USA.
Mark A RutherfordDepartment of Otolaryngology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
Rick A FriedmanDivision of Otolaryngology, Department of Surgery, University of California, San Diego, 9500 Gilman Drive, Mail Code 0666, La Jolla, CA 92093, USA.
Jeffrey N SavasDepartment of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Northwestern University · USSalk Institute for Biological Studies · USUniversity of California, San Diego · USWashington University in St. Louis · US

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Daniela E Matei · 1993 to 2026
$153.9M
EXCITATION AND EXCITOTOXICITY IN TYPE I COCHLEAR AFFERENTS: SYNAPTIC STRUCTURE AND FUNCTIONR01DC014712 · NIDCD · WASHINGTON UNIVERSITY · PI Mark Allen Rutherford · 2016 to 2026
$5.6M
Training Program in Neurobiology of Information StorageT32MH067564 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Daniel A Dombeck · 2003 to 2026
$4.7M
The genetic basis for age-related hearing loss in outbred miceR01DC018566 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FRIEDMAN, RICK A · 2020 to 2024
$2.7M
Proteome Biology of Noise Induced Hearing LossR00DC013805 · NIDCD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SAVAS, JEFFREY NICHOLAS · 2015 to 2017
$747k
A Novel Model System for Restoring Hearing in vivoR21DC018237 · NIDCD · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI COLEMAN, TODD P, KYRIAKAKIS, PHILLIP · 2020 to 2021
$505k
NCI NIH HHS P30 CA060553NIDCD NIH HHS R00 DC013805NIDCD NIH HHS R01 DC014712NIDCD NIH HHS R01 DC018566NIDCD NIH HHS R21 DC018237NIMH NIH HHS T32 MH067564
6 · The paper itself

Abstract

Hearing depends on precise synaptic transmission between cochlear inner hair cells and spiral ganglion neurons through afferent ribbon synapses. Neuroligins (Nlgns) facilitate synapse maturation in the brain, but they have gone unstudied in the cochlea. We report

Indexed as

cellular neurosciencegenomicsneurosciencesensory neuroscience

Identifiers

PMID35992071
PMCPMC9386149
OpenAlexW4286268404

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.